Çalışmamızda kısa etkili non-depolarizan bir ajan olan mivakuryum ile prekürizasyonun göz içi basıncına (GIB) etkisini araştırmayı amaçladık. ASA 1 risk grubunda non-oftalmik cerrahi operasyon geçirecek 18-50 yaşlarında 30 olgu; çift kör, randomize, plasebo kontrollü olarak iki gruba ayrıldı. Prekürizasyonda; 1. Gruba (n=15) 0.02 mg kg-1 10 mL serum fizyolojik içinde mivakuryum, II. gruba (n=15) ise sadece 10 mL serum fizyolojik uygulandı. Her iki grupta da prekürarizasyondan 3 dk sonra alfentanil 20 µg kg-1, propofol 2 mg kg-1 iv verilerek indüksiyon yapıldı. Daha sonra 1.5 mg kg-1 süksinilkolin verilerek, olgular 1. dakikanın sonunda entübe edildi. Süksinilkoline bağlı fasikülasyonlar ve entübasyon kalitesi skorlanarak değerlendirildi. GIB ölçümleri Schioetz Tonometresi ile prekürarizasyondan önce (bazal), prekürarizasyondan 3 dk sonra, süksinilkolinden 1 dk sonra, entübasyondan sonraki 5 dk süresince 1 dk arayla yapıldı. GİB; süksinilkolin uygulanımından 60 saniye sonra I. Grupta 10.7±3.67 mmHg, II. Grupta ise 17.3±2.30 mmHg olarak saptandı ve iki grup arasında istatistiksel olarak anlamlı fark belirlendi (p

In our study we aimed to determine the effects of mivacurium pretreatment, a short-acting nondepolarizing neuromuscular drug, on the intra-ocular pressure response to succinylcholine and tracheal intubation. This study was performed in 30 patients in ASA class I between 18-50 y ears of age, undergoing non-ophthalmic surgery, in a double-blind, randomized, placebo controlled study design. The patients were randomly allocated to receive either mivacurium 0.02 mg kg^-1 or normal saline for precurarization (n=15 in each group). Induction of anesthesia was performed with alfentanil 20 µg kg^-1 and propofol 2 mg kg^-1 given 3 minutes after precurarization. One minute after the administration of 1.5 mg kg^-1 succinylcholine, intubation was performed. Fasciculations due to succinylcholine and the quality of intubation were evaluated by a scoring system. Intraocular pressure (IOP) was measured by Schioetz tonometer in both groups prior to precurarization (basaline), 3 minutes after precurarization, 1 minutes after succinylcholine administration and in I minute intervals during the first 5 minutes following intubation. Mean IOP values measured 60 seconds after succinylcholine administration were 10.7±3.67 mmHg in mivacurium group and 17.3±2.30 mmHg in placebo group. The difference between the groups was statistically significant (p<0.05). No significant different was observed in other measurements. Mean arterial pressure and heart rate values did not differ between the two groups. Fasciculation scores were evaluated as 80% in placebo group and 40% in mivacurium group whereas, the intubation quality did not differ between the groups. It is concluded that precurarization with mivacurium reduced IOP which was increased by succinylcholine.