Mehmet CESUR, M. Şahin YÜKSEK, FAZLI ERDOĞAN, Hacı Ahmet ALICI, Nazım DOĞAN, Sabahattin USLU

Halotan,izofluran ve sevofluranın tavşan karaciğeri üzerine etkilerinin karşılaştırılması

Bu çalışmada; halotan, izofluran ve sevofluranın hepatik etkileri biyokimyasal ve histopatolojik olarak karşılaştırıldı. Yeni Zelanda tipi 40 tavşandan; biri kontrol, üçü de ilaç grupları olmak üzere dört eşit gruba ayrıldı. Bu deneklere on gün arayla altışar saat %100 O2, %1.4 halotan, %2.05 izofluran veya %3.7 sevofluran uygulandı. Deneklerden birinci anestezi uygulamasından önce, 24 saat ve 7 gün sonra ve ikinci anestezi uygulamasından 24 saat sonra, olmak üzere dört kez biyokimyasal değerlendirme için kan örnekleri alındı ve karaciğerleri histopatolojik olarak değerlendirildi. Biyokimyasal olarak en fazla enzim artışı halotan grubunda kaydedildi. Onu sırasıyla izofluran ve sevofluran grubu izledi. En fazla histopatolojik hasar ise halotan grubunda gözlenmiş, onu izofluran takip etmiş, en az hasar ise sevofluranda bulunmuş, fakat istatistiksel olarak izofluranla sevofluran arasında f ark belirlenmemiştir.

Anahtar Kelimeler:

Modeller, hayvan, Halotan, Histolojik teknikler, Karaciğer, Anestezikler, Biyokimya, Histoloji, karşılaştırmalı, İzofluran, Tavşanlar

The comparative effects of halothane, isoflurane and sevoflurane on liver in rabbits

This study compared the effects of halothane, isoflurane and sevoflurane on liver in rabbits by using biochemical laboratory evaluation and histopathological investigation. New Zealand rabbits were assigned to 4 groups as three treatment groups and one control. These groups were anesthetized twice with oxygen 100%, halothane 1.4%, isoflurane 2.05% and sevoflurane 3.7% for six hours with ten-day intervals. In blood samples levels of hepatic enzymes were assessed and the livers were investigated histopathologically. The most increase was seen in the halothane, isoflurane and sevoflurane groups successively in the biochemical analysis. In the histopathological examinations, the most marked damage was observed in the halothane and isoflurane groups, and the least was in the sevoflurane group. But there was no significant difference between isoflurane and sevoflurane groups.

Keywords:

Models, Animal, Halothane, Histological Techniques, Liver, Anesthetics, Biochemistry, Histology, Comparative, Isoflurane, Rabbits,

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