Süleyman GANİDAĞLI, Semra DEMİRBİLEK, Nurettin BAYHAN

Mivakuryumun etki başlama süresine efedrinin etkisi

Çalışmamızda indüksiyon öncesi verilen efedrinin mivakuryumun etki başlama süresi üzerine etkisini araştırdık. Yaşları 18-63 arasında değişen ASA I-II risk grubunda, elektif cerrahi planlanan 50 olgu çalışma kapsamına alındı. Olgulara premedikasyon olarak 0.1 mg kg-1 im midazolani verildi. Olguların kalp atım hızları (KAH), sistolik arter basınçları (SAB), diyastolik arter basınçları (DAB), periferik oksijen satürasyonları (SpO2); preoperatif olarak, efedrin veya serum fizyolojiğin iv verilmesinden sonra ve entübasyon sonrası 1, 3 ve 5. dakikalarda kaydedildi. Olgulara indüksiyondan önce rastgele ya 70 µg kg-1 efedrin (Grup I, n=25) veya 5 mL serum fizyolojik (Grup II, n=25) iv verildi. İndüksiyon her iki grupta 2 µg kg-1 fentanili takiben, 2 mg kg-1 propofol ve 0.2 mg kg-1 mivakuryum ile sağlandı. Nöromuskuler blok monitörize edildi ve TOF uyarısıyla değerlendirildi. Nöromuskuler blok % 0-5'e ulaştıktan sonra endotrakeal entübasyon yapıldı. Entübasyon süreleri ve entübasyon skorları kaydedildi. Entübasyon skoru açısından, gruplar arasında farklılık gözlenmezken, entübasyon süresi Grup I'de anlamlı olarak daha kısa idi (p

Anahtar Kelimeler:

Zaman, Yaşlı, Erişkin, Cerrahi işlemler, elektif, Risk faktörleri, Efedrin, Entübasyon

The effect of ephedrine on the onset time of mivacurium

We examined the effects of ephedrine given before induction on the onset time of mivacurium. We studied 50 patients in ASA I-II, aged between 18 to 63 years undergoing elective surgical procedures. Midazolam 0.1 mg kg -1 was given to the patients intramuscularly for premedication. Heart Rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and peripheral oxygen saturation (SpO2)of the patients were recorded preoperatively, after ephedrine or saline injections and 1, 3 and 5 minutes after the tracheal intubation. The patients were randomly allocated to receive either ephedrine 70 µg kg-1 (Group I, n=25) or only 5 mL of saline (Group II, n=25) before induction. The induction of anesthesia was performed with propofol 2 mg kg-1 and mivacurium 0.2 mg kg-1 followed by fentanyl 2 µg kg-1 and then, TOF measurements were determined. When the neuromuscular blockade reached to the level of 0-5%, endotracheal intubation was performed. Intubation times and scoring were recorded. No statistically differences were found in intubation scores of the groups. However, intubation times of the Group I were shorter than that of the Group II (p<0.05). Hemodynamic profile and side effects were similar in both groups. It was concluded that using ephedrine and mivacurium together before intubation in brief surgical procedures might provide rapid intubation conditions.

Keywords:

Time, Aged, Adult, Surgical Procedures, Elective, Risk Factors, Ephedrine, Intubation,

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