Tuba BAYINDIR, Mahmut Tayyar KALCIOĞLU, Mehmet Turan ÇİÇEK, Mustafa IRAZ, Yüksel TOPLU

The effect of lycopene on the ototoxicity induced by cisplatin*

Background/aim: To determine the efficacy of lycopene, which is considered an antioxidant agent, in decreasing the cochlear damage induced by cisplatin. Materials and methods: A total of 38 rats were randomized into 4 groups: control, cisplatin, cisplatin + lycopene, and lycopene-treated groups. In all groups, the distortion-product otoacoustic emission measurements were performed on days 0, 1, 2, and 5. Results: There were no significant differences between the control and lycopene groups at any frequencies. In the cisplatin group, the statistically significant differences were found in the measurements taken between day 0 and day 5 at all frequencies and between days 1 and 5 and days 2 and 5 at some frequencies (P < 0.05). In the cisplatin + lycopene group, a statistically significant difference was found at some frequencies between the measurements taken on days 0 and 5, days 1 and 5, and days 2 and 5 (P < 0.05). Contrary to the results found in the cisplatin group, hearing ability in the lycopene-treated group was observed as being preserved at low frequencies in the measurements taken on days 0 and 5 and days 2 and 5. Conclusion: The data of this study suggest that lycopene can prevent the development of ototoxicity induced by cisplatin, especially at low frequencies. Studies on this issue with longer durations and different dose ranges may contribute to the identification of potentially prophylactic effects of lycopene against cisplatin ototoxicity at higher frequencies, as well.

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1. Teranishi MA, Nakashima T. Effects of trolox, locally applied on round windows, on cisplatin-induced ototoxicity in guinea pigs. Int J Pediatr Otorhinolaryngol 2003; 67: 133139.
2. Rybak LP, Whitworth C, Somani S. Application of antioxidants and other agents to prevent cisplatin ototoxicity. Laryngoscope 1999; 109: 17401744.
3. Kizilay A, Kalcioglu MT, Ozerol E, Iraz M, Gulec M, Akyol O, Ozturan O. Caffeic acid phenethyl ester ameliorated ototoxicity induced by cisplatin in rats. J Chemother 2004; 16: 381387.
4. Iraz M, Kalcioglu MT, Kizilay A, Karatas E. Aminoguanidine prevent ototoxicity induced by cisplatin in rats. Ann Clin Lab Sci 2005; 35: 329335.
5. Kalcioglu MT, Kizilay A, Gulec M, Karatas E, Iraz M, Akyol O, Egri M, Ozturan O. Protective effect of erdosteine against ototoxicity induced by cisplatin in rats. Eur Arch Otorhinolaryngol 2005; 262: 856863.
6. Şanlı A, Aydın S, Sarısoy ZA, Paksoy M, Ayduran E, Çelebi Erdivanlı Ö. The protective effect of dexamethasone and lactate against cisplatin-induced ototoxicity. Turk J Med Sci 2011; 41: 467474.
7. Giovannucci E. Tomatoes, tomato-based products, lycopene and cancer: review of the epidemiologic literature. J Natl Cancer Inst 1999; 91: 317331.
8. Aydın M, Çelik S. Effect of lycopene on plasma glucose, insulin levels, oxidative stress, and body weights of streptozotocininduced diabetic rats. Turk J Med Sci 2012; 42 (Suppl. 2): 14061413.
9. Mashima R, Witting PK, Stocker R. Oxidants and antioxidants in atherosclerosis. Curr Opin Lipidol 2001; 12: 411418.
10. Boileau TW, Clinton SK, Zaripheh S, Monaco MH, Donovan SM, Erdman JW Jr. Testosterone and food restriction modulate hepatic lycopene isomer concentrations in male F344 rats. J Nutr 2001; 131: 17461752.
11. Rousseau EJ, Davison AJ, Dunn B. Protection by beta-carotene and related compounds against oxygen-mediated cytotoxicity and genotoxicity: implications for carcinogenesis and anticarcinogenesis. Free Radic Biol Med 1992; 13: 407433.
12. Nguyen ML, Schwartz SJ. Lycopene: chemical and biological properties. Food Technol 1999; 53: 3845.
13. Kalkanis JG, Whitworth C, Rybak LP. Vitamin E reduces cisplatin ototoxicity. Laryngoscope 2004; 114: 538542.
14. Bramley PM. Is lycopene beneficial to human health? Phytochemistry 2000; 54: 233236.
15. Khachik F, Carvalho L, Bernstein PS, Muir GJ, Zhao DY, Katz NB. Chemistry, distribution and metabolism of tomato carotenoids and their impact on human health. Exp Biol Med (Maywood) 2002; 227: 845851.
16. Gupta SK, Trivedi D, Srivastava S, Joshi S, Halder N, Verma SD. Lycopene attenuates oxidative stress induced experimental cataract development: an in vitro and in vivo study. Nutrition 2003; 19: 794799.
17. Breinholt V, Lauridsen ST, Daneshvar B, Jakobsen J. Doseresponse effects of lycopene on selected drug-metabolizing and antioxidant enzymes in the rat. Cancer Lett 2000; 154: 201210.
18. Cadenas E, Packer L. Handbook of Antioxidants. New York, NY, USA: Marcel Dekker Inc.; 1996.
19. Sarkar PD, Gupta T, Sahu A. Comparative analysis of lycopene in oxidative stress. J Assoc Physicians India 2012; 60: 1719.
20. Yilmaz S, Atessahin A, Sahna E, Karahan I, Ozer S. Protective effect of lycopene on Adriamycin-induced cardiotoxicity and nephrotoxicity. Toxicology 2006; 218: 164171.
21. Karahan İ, Ateşşahin A, Yilmaz S, Çeribaşı AO, Sakin F. Protective effect of lycopene on gentamicin-induced oxidative stress and nephrotoxicity in rats. Toxicology 2005; 215: 198 204.
22. Ateşşahin A, Yilmaz S, Karahan İ, Çeribaşı AO, Karaoğlu A. Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats. Toxicology 2005; 212: 116123.