Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation

Both bupivacaine and levobupivacaine are local anesthetics with strong analgesic efficacy that can be used intraarticularly. The aim of this study was to compare the effects of intraarticular bupivacaine and levobupivacaine injection on inflammation in articular cartilage and the synovium of the rat knee joint. Materials and methods: Twenty Sprague-Dawley rats were injected in the right knee joint with 0.2 mL of bupivacaine, while 0.2 mL of levobupivacaine was injected into the left knee joint. Groups of 5 were sacrificed on days 1, 7, 14, and 21 after bupivacaine and levobupivacaine administration and knee joints were examined for subintimal fibrosis, synovial hyperplasia, chronic inflammation, neutrophil infiltration, edema, and synovial and periarticular congestion by microscopy. Alterations in the articular cartilage structure were evaluated using Mankin scoring. Results: We found that both drugs have similar effects on synovial and articular cartilage resulting in mild to moderate congestion, edema, neutrophil infiltration, chronic inflammation, and synovial hyperplasia, which diminished gradually. However, increases in fibrosis were also seen to varying degrees. Thus, the use of these drugs intraarticularly can be recommended. Conclusion: Careful usage of bupivacaine and levobupivacaine is recommended in intraarticular applications since they cause inflammation shortly after injection and fibrosis at later time points.

Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation

Both bupivacaine and levobupivacaine are local anesthetics with strong analgesic efficacy that can be used intraarticularly. The aim of this study was to compare the effects of intraarticular bupivacaine and levobupivacaine injection on inflammation in articular cartilage and the synovium of the rat knee joint. Materials and methods: Twenty Sprague-Dawley rats were injected in the right knee joint with 0.2 mL of bupivacaine, while 0.2 mL of levobupivacaine was injected into the left knee joint. Groups of 5 were sacrificed on days 1, 7, 14, and 21 after bupivacaine and levobupivacaine administration and knee joints were examined for subintimal fibrosis, synovial hyperplasia, chronic inflammation, neutrophil infiltration, edema, and synovial and periarticular congestion by microscopy. Alterations in the articular cartilage structure were evaluated using Mankin scoring. Results: We found that both drugs have similar effects on synovial and articular cartilage resulting in mild to moderate congestion, edema, neutrophil infiltration, chronic inflammation, and synovial hyperplasia, which diminished gradually. However, increases in fibrosis were also seen to varying degrees. Thus, the use of these drugs intraarticularly can be recommended. Conclusion: Careful usage of bupivacaine and levobupivacaine is recommended in intraarticular applications since they cause inflammation shortly after injection and fibrosis at later time points.

Kaynakça

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Kaynak Göster

Bibtex @ { tbtkmedical146659, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2014}, volume = {44}, pages = {540 - 545}, doi = {10.3906/kim-1207-18}, title = {Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation}, key = {cite}, author = {Kürkçüoğlu, Bekir Suat and Dönmez, Melehat and Altınel, Seher and Akıncı, Seda Banu} }
APA Kürkçüoğlu, B , Dönmez, M , Altınel, S , Akıncı, S . (2014). Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation . Turkish Journal of Medical Sciences , 44 (4) , 540-545 . DOI: 10.3906/kim-1207-18
MLA Kürkçüoğlu, B , Dönmez, M , Altınel, S , Akıncı, S . "Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation" . Turkish Journal of Medical Sciences 44 (2014 ): 540-545 <
Chicago Kürkçüoğlu, B , Dönmez, M , Altınel, S , Akıncı, S . "Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation". Turkish Journal of Medical Sciences 44 (2014 ): 540-545
RIS TY - JOUR T1 - Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation AU - Bekir Suat Kürkçüoğlu , Melehat Dönmez , Seher Altınel , Seda Banu Akıncı Y1 - 2014 PY - 2014 N1 - doi: 10.3906/kim-1207-18 DO - 10.3906/kim-1207-18 T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 540 EP - 545 VL - 44 IS - 4 SN - 1300-0144-1303-6165 M3 - doi: 10.3906/kim-1207-18 UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation %A Bekir Suat Kürkçüoğlu , Melehat Dönmez , Seher Altınel , Seda Banu Akıncı %T Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation %D 2014 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 44 %N 4 %R doi: 10.3906/kim-1207-18 %U 10.3906/kim-1207-18
ISNAD Kürkçüoğlu, Bekir Suat , Dönmez, Melehat , Altınel, Seher , Akıncı, Seda Banu . "Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation". Turkish Journal of Medical Sciences 44 / 4 (Mayıs 2014): 540-545 .
AMA Kürkçüoğlu B , Dönmez M , Altınel S , Akıncı S . Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation. Turkish Journal of Medical Sciences. 2014; 44(4): 540-545.
Vancouver Kürkçüoğlu B , Dönmez M , Altınel S , Akıncı S . Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation. Turkish Journal of Medical Sciences. 2014; 44(4): 540-545.
IEEE B. Kürkçüoğlu , M. Dönmez , S. Altınel ve S. Akıncı , "Comparison of intraarticular bupivacaine and levobupivacaine injection in rat synovial inflammation", Turkish Journal of Medical Sciences, c. 44, sayı. 4, ss. 540-545, May. 2014, doi:10.3906/kim-1207-18
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK

25.2b 24.3b

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