Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures

To comparatively investigate the effects of linoleic acid on convulsive and nonconvulsive epileptic seizures. Materials and methods: Rats were divided into 3 groups: convulsive epileptic rats receiving only pentylentetrazole (PTZ) injections (group 1), convulsive epileptic rats receiving PTZ and linoleic acid (group 2), and Wistar Albino Glaxo rats from Rijswijk with genetic absence epilepsy receiving linoleic acid (group 3). The duration and severity of convulsive activity were determined in groups in which convulsive seizures were induced by PTZ. In group 3, intravenous linoleic acid was administered after 1-h baseline electroencephalography (EEG) recordings. The EEG recordings were analyzed. Results: When groups 1 and 2 were compared, the delay in onset of minor seizures and the decrease in the number of rats developing major seizures were found statistically significant. When the mean spike-wave discharge number and duration values for the rats in group 3 were compared to baseline values, a statistically significant increase was found in the 1st and 6th hours and there was no significant difference in the 24th hour. Conclusion: While our study shows that linoleic acid may be effective in the treatment of generalized convulsive epilepsy along with conventional antiepileptic drugs used in epilepsy treatment, it reports that linoleic acid is not appropriate in the treatment of nonconvulsive epilepsies.

Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures

To comparatively investigate the effects of linoleic acid on convulsive and nonconvulsive epileptic seizures. Materials and methods: Rats were divided into 3 groups: convulsive epileptic rats receiving only pentylentetrazole (PTZ) injections (group 1), convulsive epileptic rats receiving PTZ and linoleic acid (group 2), and Wistar Albino Glaxo rats from Rijswijk with genetic absence epilepsy receiving linoleic acid (group 3). The duration and severity of convulsive activity were determined in groups in which convulsive seizures were induced by PTZ. In group 3, intravenous linoleic acid was administered after 1-h baseline electroencephalography (EEG) recordings. The EEG recordings were analyzed. Results: When groups 1 and 2 were compared, the delay in onset of minor seizures and the decrease in the number of rats developing major seizures were found statistically significant. When the mean spike-wave discharge number and duration values for the rats in group 3 were compared to baseline values, a statistically significant increase was found in the 1st and 6th hours and there was no significant difference in the 24th hour. Conclusion: While our study shows that linoleic acid may be effective in the treatment of generalized convulsive epilepsy along with conventional antiepileptic drugs used in epilepsy treatment, it reports that linoleic acid is not appropriate in the treatment of nonconvulsive epilepsies.

Kaynakça

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Kaynak Göster

Bibtex @ { tbtkmedical146658, journal = {Turkish Journal of Medical Sciences}, issn = {1300-0144}, eissn = {1303-6165}, address = {}, publisher = {TÜBİTAK}, year = {2014}, volume = {44}, pages = {535 - 539}, doi = {10.3906/muh-1109-9}, title = {Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures}, key = {cite}, author = {Ekici, Fatih and Gürol, Gönül and Ateş, Nurbay} }
APA Ekici, F , Gürol, G , Ateş, N . (2014). Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures . Turkish Journal of Medical Sciences , 44 (4) , 535-539 . DOI: 10.3906/muh-1109-9
MLA Ekici, F , Gürol, G , Ateş, N . "Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures" . Turkish Journal of Medical Sciences 44 (2014 ): 535-539 <
Chicago Ekici, F , Gürol, G , Ateş, N . "Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures". Turkish Journal of Medical Sciences 44 (2014 ): 535-539
RIS TY - JOUR T1 - Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures AU - Fatih Ekici , Gönül Gürol , Nurbay Ateş Y1 - 2014 PY - 2014 N1 - doi: 10.3906/muh-1109-9 DO - 10.3906/muh-1109-9 T2 - Turkish Journal of Medical Sciences JF - Journal JO - JOR SP - 535 EP - 539 VL - 44 IS - 4 SN - 1300-0144-1303-6165 M3 - doi: 10.3906/muh-1109-9 UR - Y2 - 2021 ER -
EndNote %0 Turkish Journal of Medical Sciences Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures %A Fatih Ekici , Gönül Gürol , Nurbay Ateş %T Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures %D 2014 %J Turkish Journal of Medical Sciences %P 1300-0144-1303-6165 %V 44 %N 4 %R doi: 10.3906/muh-1109-9 %U 10.3906/muh-1109-9
ISNAD Ekici, Fatih , Gürol, Gönül , Ateş, Nurbay . "Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures". Turkish Journal of Medical Sciences 44 / 4 (Mayıs 2014): 535-539 .
AMA Ekici F , Gürol G , Ateş N . Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures. Turkish Journal of Medical Sciences. 2014; 44(4): 535-539.
Vancouver Ekici F , Gürol G , Ateş N . Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures. Turkish Journal of Medical Sciences. 2014; 44(4): 535-539.
IEEE F. Ekici , G. Gürol ve N. Ateş , "Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures", Turkish Journal of Medical Sciences, c. 44, sayı. 4, ss. 535-539, May. 2014, doi:10.3906/muh-1109-9
  • ISSN: 1300-0144
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK

24.6b 23.7b

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