Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures

To comparatively investigate the effects of linoleic acid on convulsive and nonconvulsive epileptic seizures. Materials and methods: Rats were divided into 3 groups: convulsive epileptic rats receiving only pentylentetrazole (PTZ) injections (group 1), convulsive epileptic rats receiving PTZ and linoleic acid (group 2), and Wistar Albino Glaxo rats from Rijswijk with genetic absence epilepsy receiving linoleic acid (group 3). The duration and severity of convulsive activity were determined in groups in which convulsive seizures were induced by PTZ. In group 3, intravenous linoleic acid was administered after 1-h baseline electroencephalography (EEG) recordings. The EEG recordings were analyzed. Results: When groups 1 and 2 were compared, the delay in onset of minor seizures and the decrease in the number of rats developing major seizures were found statistically significant. When the mean spike-wave discharge number and duration values for the rats in group 3 were compared to baseline values, a statistically significant increase was found in the 1st and 6th hours and there was no significant difference in the 24th hour. Conclusion: While our study shows that linoleic acid may be effective in the treatment of generalized convulsive epilepsy along with conventional antiepileptic drugs used in epilepsy treatment, it reports that linoleic acid is not appropriate in the treatment of nonconvulsive epilepsies.

Anahtar Kelimeler:

Key words: Linoleic acid, epilepsy, pentylentetrazole

Effects of linoleic acid on generalized convulsive and nonconvulsive epileptic seizures

Keywords:

Key words: Linoleic acid, epilepsy, pentylentetrazole,

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Kayaalp O. Rasyonel Tedavi Yönünden Tıbbi Farmakoloji. 7th ed. Ankara, Turkey: Güneş Kitapevi; 1995 (book in Turkish).
Gilroy J. Temel Nöroloji (Karabudak R, translator). 3rd ed. Ankara, Turkey: Güneş Kitabevi; 2002 (book in Turkish).
Bora İ, Taşkapılıoğlu Ö. Epilepsi tedaviside yeni yönelimler. Epilepsi 2003; 9: 91–102 (article in Turkish).
Cardenas-Rodriguez N, Huerta-Gertrudis B, Rivera-Espinosa L, Montesinos-Correa H, Bandala C, Carmona-Aparicio L, Coballase-Urrutia E. Role of oxidative stress in refractory epilepsy: evidence in patients and experimental models. Int J Mol Sci 2013; 14: 1455–1476.
Uran N, Serdaroğlu G, Serdaroğlu E, Kalkan S, Özcan T. Highdose intravenous immunoglobulin treatment in intractable childhood epilepsy. Turk J Med Sci 2000; 30: 495–498.
Fischer RS. Animal models of epilepsies. Brain Res Rev 1989; 14: 245–278.
Öztaş B. Konvulsiyonların patogenezinde nöron düzeyinde yaklaşım. Nöropsikiyatri Arşivi 1986; 23: 1–2 (article in Turkish).
Başoğlu M. Epilepsiler. 1st ed. İzmirTurkey: Bilim Ofset; 1988 (book in Turkish).
Van Luijtelaar ELJM, Ates N, Coenen AML. Role of L-type calcium channel modulation in nonconvulsive epilepsy in rats. Epilepsia 1995; 36: 86–92.
Futatsugi Y, Riviello JJ Jr. Mechanisms of generalized absence epilepsy. Brain Dev 1998; 20: 75–79.
Tsakiridou E, Bertollini L, Curtis M, Avanzini G, Pape HC. Selective increase in T-type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy. J Neuroscience 1995; 15: 3110–3117.
Champe PC, Harvey RA. Lippincott Biyokimya (Ulukaya E, translator). 2nd ed. Ankara, Turkey: Nobel Yayın Dağıtım; 2000 (book in Turkish).
Lauritzen I, Blondeau N, Hearteaux C, Widmann C, Romey G, Lazdunski M. Polyunsaturated fatty acids are potent neuroprotectors. EMBO J 2000; 19: 1784–1793.
Yuen AW, Sander JW, Fluegel D, Patsalos PN, Bell GS, Johnson T, Koepp MJ. Omega-3 fatty acid supplementation in patients with chronic epilepsy: a randomized trial. Epilepsy Behav 2005; 7: 253–258.
Xu XP, Erichsen D, Börjesson SI, Dahlin M, Amark P, Elinder F. Polyunsaturated fatty acids and cerebrospinal fluid from children on the ketogenic diet open a voltage-gated K channel: a putative mechanism of antiseizure action. Epilepsy Res 2008; 80: 57–66.
Puskas LG, Kitajka K. Nutrigenomic approaches to study the effects of n-3 PUFA diet in the central nervous system. Nutr Health 2006; 18: 227–232.
Taha AY, Filo E, Ma DW, McIntyre Burnham W. Dosedependent anticonvulsant effects of linoleic and alpha linolenic polyunsaturated fatty acids on pentylenetetrazol induced seizures in rats. Epilepsia 2009; 50: 72–82.
Onat FY, Aker RG. Epilepside deneysel modeller. Türkiye Klinikleri J Neurol Special Topics 2008; 1: 17–24 (article in Turkish).
Mares P, Mirvaldova H, Belska M. Influence of a new antiepileptic drug ORG 6370 on metrazol-induced seizures in rats during ontogenesis. Physiol Bohemoslov 1990; 39: 199–205.
Przewlocka B, Lason W, Turchan J, de Bruin N, van Luijtelaar ELJM, Przewlocki R, Coenen A. Anatomical and functional aspects of mu opioid receptors in epileptic WAG/Rij rats. Epilepsy Res 1998; 29: 167–173.
Voskuyl RA, Vreugdenhil M, Kang JX, Leaf A. Anticonvulsant effect of polyunsaturated fatty acids in rats, usıng the cortical stimulation model. Eur J Pharmacol 1998; 341: 145–152.