Comparison in clinical features and life impact between juvenile-onset and adult-onset ankylosing spondylitis

To compare the differences in clinical characteristics and disease impact on life between patients with juvenile-onset ankylosing spondylitis (JoAS) and patients with adult-onset AS (AoAS). Materials and methods: Demographic and clinical data were collected from 139 AS patients. Disease activity was defined with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Functional status was assessed with the Bath Ankylosing Spondylitis Functional Index (BASFI). Status of quality of life was evaluated with the Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire. Results: There were 50 patients with JoAS (36.0%) and 89 with AoAS (64.0%). The JoAS group showed more onset with peripheral joints involvement (P < 0.001), significant diagnosis delay (P < 0.001), worse functional status (P = 0.002), and poorer quality of life (P = 0.002). Patients with JoAS also showed a significantly lower rate in college education (P = 0.037) and marriage (P = 0.013). The rate of employment in the JoAS group was lower than that in the AoAS group. Although the difference in employment did not reach a significant level, the JoAS group included more patients who had not been employed since reaching adulthood (P = 0.015). Conclusion: Compared to patients with AoAS, patients with JoAS may need more specific clinical interventions as well as social assistance.

Anahtar Kelimeler:

Key words: Adult-onset ankylosing spondylitis, juvenile-onset ankylosing spondylitis, physical function, quality of life

Comparison in clinical features and life impact between juvenile-onset and adult-onset ankylosing spondylitis

Keywords:

Key words: Adult-onset ankylosing spondylitis, juvenile-onset ankylosing spondylitis, physical function, quality of life,

PDF

___

Ward MM, Reveille JD, Learch TJ, Davis JJ, Weisman MH. Impact of ankylosing spondylitis on work and family life: comparisons with the US population. Arthritis Rheum 2008; 59: 497–503.
Packham JC, Jordan KP, Haywood KL, Garratt AM, Healey EL. Evaluation of Ankylosing Spondylitis Quality of Life questionnaire: responsiveness of a new patient-reported outcome measure. Rheumatology (Oxford) 2012; 51: 707–714. 3. Bukulmez H, Colbert RA. Juvenile spondyloarthropathies and related arthritis. Curr Opin Rheumatol 2002; 14: 531–535.
O’Shea FD, Boyle E, Riarh R, Tse SM, Laxer RM, Inman RD. Comparison of clinical and radiographic severity of juvenile- onset versus adult-onset ankylosing spondylitis. Ann Rheum Dis 2009; 68: 1407–1412.
Marks SH, Barnett M, Calin A. A case-control study of juvenile- and adult-onset ankylosing spondylitis. J Rheumatol 1982; 9: 739–741.
Ozgocmen S, Ardicoglu O, Kamanli A, Kaya A, Durmus B, Yildirim K, Baysal O, Gur A, Karatay S, Altay Z et al. Pattern of disease onset, diagnostic delay, and clinical features in juvenile onset and adult onset ankylosing spondylitis. J Rheumatol 2009; 36: 2830–2833.
Stone M, Warren RW, Bruckel J, Cooper D, Cortinovis D, Inman RD. Juvenile-onset ankylosing spondylitis is associated with worse functional outcomes than adult-onset ankylosing spondylitis. Arthritis Rheum 2005; 53: 445–451.
Baek HJ, Shin KC, Lee YJ, Kang SW, Lee EB, Yoo CD, Song YW. Juvenile onset ankylosing spondylitis (JAS) has less severe spinal disease course than adult onset ankylosing spondylitis (AAS): clinical comparison between JAS and AAS in Korea. J Rheumatol 2002; 29: 1780–1785.
Baraliakos X, Braun J. Hip involvement in ankylosing spondylitis: what is the verdict? Rheumatology (Oxford) 2010; 49: 3–4.
Garcia-Morteo O, Maldonado-Cocco JA, Suarez-Almazor ME, Garay E. Ankylosing spondylitis of juvenile onset: comparison with adult onset disease. Scand J Rheumatol 1983; 12: 246–248.
Kim TJ, Kim TH. Clinical spectrum of ankylosing spondylitis in Korea. Joint Bone Spine 2010; 77: 235–240.
Calin A, Elswood J. The natural history of juvenile-onset ankylosing spondylitis: a 24-year retrospective case-control study. Br J Rheumatol 1988; 27: 91–93.
Gensler LS, Ward MM, Reveille JD, Learch TJ, Weisman MH, Davis JJ. Clinical, radiographic and functional differences between juvenile-onset and adult-onset ankylosing spondylitis: results from the PSOAS cohort. Ann Rheum Dis 2008; 67: 233– 237.
van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum 1984; 27: 361–368.
Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol 1994; 21: 2286–2291.
Calin A, Garrett S, Whitelock H, Kennedy LG, O’Hea J, Mallorie P, Jenkinson T. A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index. J Rheumatol 1994; 21: 2281–2285.
Doward LC, Spoorenberg A, Cook SA, Whalley D, Helliwell PS, Kay LJ, McKenna SP, Tennant A, van der Heijde D, Chamberlain MA. Development of the ASQoL: a quality of life instrument specific to ankylosing spondylitis. Ann Rheum Dis 2003; 62: 20–26.
Riley MJ, Ansell BM, Bywaters EG. Radiological manifestations of ankylosing spondylitis according to age at onset. Ann Rheum Dis 1971; 30: 138–148.
Aggarwal A, Hissaria P, Misra R. Juvenile ankylosing spondylitis—is it the same disease as adult ankylosing spondylitis? Rheumatol Int 2005; 25: 94–96.
Gensler LS, Ward MM, Reveille JD, Learch TJ, Weisman MH, Davis JJ. Clinical, radiographic and functional differences between juvenile-onset and adult-onset ankylosing spondylitis: results from the PSOAS cohort. Ann Rheum Dis 2008; 67: 233– 237.
Zochling J, Braun J. Assessments in ankylosing spondylitis. Best Pract Res Clin Rheumatol 2007; 21: 699–712.
Bodur H, Ataman S, Rezvani A, Bugdayci DS, Cevik R, Birtane M, Akinci A, Altay Z, Gunaydin R, Yener M et al. Quality of life and related variables in patients with ankylosing spondylitis. Qual Life Res 2011; 20: 543–549.
Montacer KM, Mehdi GM, Hamdi W, Azzouz D, Kochbati S, Saadellaoui K, Daoud L, Hamida AB, Zouari MB. Impact of the ankylosing spondylitis on the professional activity. Joint Bone Spine 2009; 76: 378–382.
Boonen A, Braun J, van der Horst BI, Huang F, Maksymowych W, Kostanjsek N, Cieza A, Stucki G, van der Heijde D. ASAS/ WHO ICF Core Sets for ankylosing spondylitis (AS): how to classify the impact of AS on functioning and health. Ann Rheum Dis 2010; 69: 102–107.
Boonen A, Mau W. The economic burden of disease: comparison between rheumatoid arthritis and ankylosing spondylitis. Clin Exp Rheumatol 2009; 27: S112–117.
Roussou E, Kennedy LG, Garrett S, Calin A. Socioeconomic status in ankylosing spondylitis: relationship between occupation and disease activity. J Rheumatol 1997; 24: 908– 911.
Ward MM, Reveille JD, Learch TJ, Davis JJ, Weisman MH. Impact of ankylosing spondylitis on work and family life: comparisons with the US population. Arthritis Rheum 2008; 59: 497–503.