Ali AKBAŞ, İlker ETİKAN, Ali YEGİNSU, Hüseyin ÖZYURT, Çiğdem ELMAS, Makbule ERGİN, Güleser Çağlar GÖKTAŞ

Ekstremite iskemi reperfüzyonuna bağlı akciğer hasarında metilprednizolonun etkileri

Amaç: Bu çalışmada ektremite iskemi reperfüzyonu sonrasında gelişen akciğer hasarının önlenmesinde metilprednizolonun etkileri araştırıldı.Çalışma planı: Çalışmada 30 adet Wistar albino cinsi sıçan kullanıldı. Sıçanlar her bir grupta altı sıçan olacak şekilde rastgele beş gruba ayrıldı. Sıçanlarda sol alt ekstremite iskemisi yaratıldı. Reperfüzyon öncesi tek doz 15, 50 ve 150 mg/kg metilprednizolon verildi. Deneklerin serum ve akciğer örnekleri alınarak akciğer hasarı ve sistemik inflamasyon parametreleri çalışıldı. Bulgular istatistiksel olarak değerlendirildi.Bulgular: Tüm inflamasyon parametreleri (lökosit, nötrofil yüzdesi, laktat dehidrojenaz, malondialdehit, süperoksit dismutaz, glutatyon peroksidaz, interlökin-8 ve tümör nekroz faktör alfa) kontrol grubuyla karşılaştırıldığında iskemi-reperfüzyon grubunda anlamlı olarak yüksek bulundu (p

The effects of methylprednisolone on the lung injury resulted from extremity ischemia reperfusion

Background: The purpose of this study was to investigate the effects of methylprednisolone on lung injury developing after extremity ischemia reperfusion.Methods: Thirty Wistar albino rats were used in the study. Rats were randomly divided into five groups, with six rats in each group. A left lower extremity ischemia was established in the rats. Before reperfusion, 15, 50, and 150 mg/ kg single doses of methylprednisolone were given to the rats. Serum and lung samples were taken, and lung damage and systemic inflammation parameters were studied. The findings were statistically evaluated.Results: In ischemia-reperfusion group, all inflammatory parameters (leukocyte, percentage of neutrophil, lactatedehydrogenase, malonedialdehyde, superoxide dismutase, glutathione peroxydase, interleukin-8, and tumor necrosis factor alpha) were significantly higher when compared to control group (p

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