SOSYAL İZOLASYON OLUŞTURULAN GENÇ ERKEK SIÇANLARDA GİNKGO BİLOBA EKSTRESİ'NİN ÖĞRENMEYE ETKİSİ

Sosyal izolasyonun ö ğ renme performansı ve belleği bozduğu, Ginkgo biloba yaprak ekstresi uygulamasının ise olumlu yö nde etkilediği bir çok çalışmada gö sterilmiştir. AncakGinkgobiloba yaprakekstresininetkilerininkronik uygulamayla ilişkili olup olmadığı ve sosyal izolasyonileeşzamanlıuygulamasınınö ğ renmeü zerindekietkileri tam olarak açıklanmamıştır. Sunulan bu çalışmada genç erkek sıçanlarda sosyal izolasyonun ve Ginkgo biloba yaprak ekstresinin kronik uygulamasının ö ğ renme ve bellek ü zerindeki etkilerinin araştırılması amaçlandı. Çalışmada;54adetWistarAlbinocinsidö rtaylıkerkek sıçan kullanıldı. Çalışma; 21 gü n boyunca her biri ayrı kafeste barındırılarak sosyal izolasyon uygulanan, ve birlikteGinkgobilobayaprakekstresiveyaserum izyolojik verilen;kafeslerdedö rt-beşhayvanolarakbarındı- rılanveGinkgobilobayaprakekstresiveyaserum izyolojik verilenveverilmeyensıçanlardanoluşanaltıgrup ile yü rü tüldü . Sıçanlar, opak malzemeden yapılmış 25×40×15 cm ebatlarındaki kafeslerde ve her gü n 12 saataydınlıkta,12saatkaranlıktakalacakşekildebarındırıldılar. Ginkgo biloba yaprakekstresi 50mg/kg/gü n dozda intraperitoneal olarak uygulandı. Uygulamalar sonundasıçanlardaMorrissutankıtestiileö ğ renmeve bellek değerlendirildi. Ekstre; kronik etkisi değerlendirileceği içintestinçalışıldığıbeşgü nuygulanmadı. Sonuçta,21gü nlü ksosyalizolasyonundö rtaylıkWistar Albino cinsi erkek sıçanlarda ö ğ renme performansı ve belleği artırdığı ve Ginkgo biloba ekstresinin verildiği dozdakronikuygulanmasınınö ğ renmevebellekişlevlerinde değişikliğenedenolmadığıbelirlendi.

EFFECTS OF GINKGO BILOBA EXTRACT ON LEARNING IN SOCIALLY ISOLATED YOUNG MALE RATS

It has been shown in many studies that social isolation deteriorates and Ginkgo biloba leaf extract application positively affects learning performance and memory. However, whether the effects of Ginkgo biloba leaf extract are related with chronic application or not and the reciprocal effects of social isolation and Ginkgo biloba leaf extract application on learning have not been fully explained yet. This study was planned to investigate the effects of social isolation and chronic application of Ginkgo biloba leaf extract on learning and memory in young male rats. Four-month-old 54 male Wistar Albino rats were used in the study. The study was conducted with six rat groups including; rats which were individually and sep- arately kept in cages and socially isolated; rats which were socially isolated and given Ginkgo biloba leaf extract or normal saline; rats which were kept as four- ive rats in cages and not socially isolated; rats which were not socially isolated and given Ginkgo biloba leaf extract or normal saline. All the rats were kept in standard non- transparent cages with a dimension of 25×40×15 cm and sheltered for 12 hours in light and for 12 hours in dark every day. Ginkgo biloba leaf extract 50 mg/kg/d was administered intraperitoneally. After 21-day social isolation and the other application, learning and memory was tested in Morris water maze. The extract was not applied during the test because the chronic effect of the extract would be evaluated. The results were evaluated and it was determined that social isolation for 21 days increased the learning performance and memory in four-month male Wistar Albino rats and that chronic application of Ginkgo biloba extract on the given dose did not lead to alteration in learning and memory.

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