MEHMET ÖNDER KARAYİĞİT, Öznur ASLAN, LATİFE ÇAKIR BAYRAM, Duygu YAMAN, AYHAN DÜZLER, İLKNUR KARACA BEKDİK, Görkem EKEBAŞ

Aortic Body Cell Tumor with Kidney Metastasis in a Dog

Bu olguda 6 aydır devam eden egzersiz intoleransı, öksürük, burun akıntısı ve kardiak aritmi şikayeti olan ve klinik bulguların kötüye gitmesi sonucunda ölen 14 yaşında erkek terrier ırkı köpek değerlendirildi. Nekropside kalp bölgesinde iki kitleye rastlandı. Mikroskobik olarak bakıldığında kitlelerden alınan kesitlerdeki hücrelerin atipi gösterdiği ve ovalden yuvarlağa kadar değişen bazofilik çekirdekli, eozinofilik-granüler sitoplazmalı ve polyhedral şekilli olduğu tespit edildi. Tümoral hücrelerin etrafı sıkı bağdokuyla çevrilmişti. Bu bulgulara ilaveten sol böbrekte tümör metastazına rastlandı. İmmunohistokimyasal olarak hem primer tümör kitlesi hem de metastazlı böbrekteki neoplastik hücreler monoklonal fare anti-neuron spesifik enolaz antikoru ile pozitif reaksiyon verirken, sitokeratin, vimentin, kromagranin A, α düz kas aktin ve S-100 antikorları ile yapılan boyamalar negatifdi. Sunulan bu vaka klinik, histopatoloj ik ve immunohistokimyasal sonuçları ile malign aortik body tümör olarak teşhis edildi.

Bir Köpekte Böbrek Metastazlı Aortik Body Hücre Tümörü

In this case, a male Terrier dog, 14-year-old evaluated with a history of cardiac arrhythmias, coughing, rhinorrhagia and exercise intolerance for six mounths. The dog was died upon worsening of clinical signs. At necropsy, two masses of various sizes were observed in the heart-base region. Microscopically, cells from masses were atypic and polyhedral with eosinophilic-granular cytoplasm and basophilic nucleus with round to oval shape. The neoplastic cells were divided into lobules by connective tissue forming nests. In addition to these findings, metastasis to the left kidney was observed. Immunohistochemically, the tumor cells from both primary and metastatic tissues showed immunoreactivity to monoclonal mouse anti-neuron specific enolase antibody but were negative for cytokeratin, vimentin, chromogranin A, α smooth muscle actin and S-100. Based on the clinical, histological and immunohistochemical findings, malignant aortic body tumor with left kidney metastasis was diagnosed in the present case.

PDF

___

1. Hayes HM, Sass B: Chemoreceptor neoplasia: A study of the epidemiological features of 357 canine cases. J Vet Med A, 35, 401-408, 1998. DOI: 10.1111/j.1439-0442.1988.tb00052.x
2. Cho KO, Park NY, Park IC, Kang BK, Onuma M: Metastatic intracavitary cardiac aortic body tumor in a dog. J Vet Med Sci, 60, 1251-1253, 1998. DOI: 10.1292/jvms.60.1251
3. Gliatto JM, Crawford MA, Snider TG, Pechman R: Multiple organ metastasis of an aortic body tumor in a Boxer. J Am Vet Med Assoc, 191 (9): 1110-1112, 1987.
4. Jubb KV, Kennedy PC: Tumors of the nonchromaffin paraganglia in dogs. Cancer, 10, 89-99, 1957. DOI: 10.1002/1097-0142(195701/02) 10:1_____89::AID-CNCR2820100112>3.0.CO;2-K
5. Montgomery DL, Bendeler, Storts RW: Malignant aortic body tumor with metastasis to bone in a dog. Vet Pathol, 17 (2): 241-244, 1980.
6. Aresu L, Tursi M, Iussich S, Guarda F, Valenza F: Use of S-100 and chromogranin A antibodies as immunohistochemical markers on detection of malignancy in aortic body tumors in dog. J Vet Med Sci, 68, 1229- 1233, 2006. DOI: 10.1292/jvms.68.1229
7. Brown PJ, Rema A, Gartner F: Immunohistochemical characteristics of canine aortic and carotid body tumors. J Vet Med Sci, 50, 140-144, 2003. DOI: 10.1046/j.1439-0442.2003.00498.x
8. Cooley AJ, Fox LE, Duncan ID, England DM: Malignant jugulotympanic paraganglioma in a dog. J Comp Pathol, 102, 375-383,1990. DOI: 10.1016/ S0021-9975(08)80159-4
9. Davis WP, Watson GL, Koehler LK, Brown CA: Malignant cauda equina paraganglioma in a cat. Vet Pathol, 34, 243-246, 1997. DOI: 10.1177/030098589703400313
10. Noszczyk-Nowak A, Nowak M, Paslawska U, Atamaniuk W, Nicpon J: Cases with manifestation of chemodectoma diagnosed in dogs in Department of Internal Diseases with Horses, Dogs and Cats Clinic, Veterinary Medicine Faculty, University of Environmental and Life Sciences, Wroclaw, Poland. Acta Vet Scand, 52, 35, 2010. DOI: 10.1186/ 1751-0147-52-35
11. Yamamoto S, Fukushima R, Hirakawa A, Abe M, Kobayashi M, Machida N: Histopathological and immunohistochemical evaluation of malignant potential in canine aortic body tumors. J Comp Pathol, 149, 182-191, 2013. DOI: 10.1016/j.jcpa.2012.
12.007 12. Saldana MJ, Salem LE, Travezan R: High altitude hypoxia and chemodectomas. Hum Pathol, 4, 251-263, 1973. DOI: 10.1016/S0046- 8177(73)80012-7
13. Yates WD, Lester SJ, Mills H: Chemoreceptor tumors diagnosed at Western College of Veterinary Medicine 1967-1979. Can Vet J, 21 (4): 124- 129, 1980.
14. Linnoila RI, Lack EE, Steinberg SM, Keiser HR: Decreased expression of neuropeptides in malignant paragangliomas: An immuno- histochemical study. Hum Pathol, 19, 41-50,1998. DOI: 10.1016/S0046- 8177(88)80314-9