Bir Kuzuda Konjenital Diyafram Fıtığı Olgusu
Bu raporun materyalini Erciyes Üniversitesi Veteriner Fakültesi Patoloj i Anabilim Dalına nekropsi isteği ile getirilen ve solunum güçlüğü nedeniyle öldüğü bildirilen dört günlük Akkaraman dişi bir kuzu oluşturdu. Nekropside diyaframda 13 cm uzunluğundaki yarıktan midenin bir kısmının göğüs boşluğuna geçtiği ve akciğerlerin sol lobuna baskı yaptığı görüldü. Göğüs boşluğuna geçen organ normal konumuna getirilince diyafram kasının yırtık kenarının inceldiği dikkati çekti. Akciğerlerin sol lobunun kollabe olduğu görüldü. Karaciğer üzerinde 8-12 cm büyüklüklerinde gri beyaz renkli değişikliklerin varlığı tespit edildi. Mikroskobik olarak, diyafram kasının yırtık kenarının fibröz dokudan oluştuğu gözlendi. Akciğerlerde atelektazik alanlar ile karaciğerde hepatositlerde yağ dejenerasyonu görüldü. Kuzularda ender görülen, nekropsi bulguları ve histopatoloj ik incelemeler sonucunda konjenital diyafram fıtığı olarak tanımlanan bu olgu Türkiyeden bildirilen ilk vakadır.
Congenital Diaphragmatic Hernia Case in a Lamb
In this report, a four days old lamb was referred to Erciyes University, Pathology Department of Veterinary Medicine with a request of necropsy and reported with died from respiratory distress. At necropsy, it was seen that a portion of the stomach pass into the chest cavity from the 13 cm in length slit of diaphragm and found to compressing the left lobe of the lung. When the herniation brought to the normal position, the side in cleft part of diaphragm muscle was noticed that it was thinner. The left lobe of the lung was collapsed and also the presence of 8-12 cm sizes gray white discoloration was observed on liver. Microscopically, the rupture edges of the diaphragm muscle were composed of fibrous tissue. Atelectasis areas were seen in the lungs due from the stomach pressure and also fatty degeneration of the hepatocytes was observed in liver.This report was defined with results of necropsy and histopathological findings as a congenital diaphragmatic hernia which was the first case report in Turkey because of its rarity in lambs.
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- 1. Tovar JA: Congenital diaphragmatic hernia. Orphanet J Rare Dis, 7, 1, 2012.
- 2. Waag KL, Loff S, Zahn K, Ali M, Hien S, Kratz M, Neff W, Schaffelder R, Schaible R: Kongenital diaphragmatic hernia: A modern day approach. Semin Pediatr Surg, 17, 244-254, 2008. DOI: 10.1053/j .sempedsurg. 2008.07.009
- 3. Barrett RB, Kittrell JE: Congenital peritoneopericardial diaphragmatic hernia in a cat. Vet Radiol, 7, 21-26, 1966. DOI: 10.1111/j.1740-8261.1966. tb01059.x
- 4. Baker GJ, Williams CSF: Diaphragmatic pericardial hernia in the dog. Vet Rec, 78, 578-583, 1966. DOI: 10.1136/vr.78.17.578
- 5. Bolton GR, Ettinger S, Rousch JC: Congenital peritoneopericardial diaphragmatic hernia in a dog. JAVMA, 155, 723-730, 1969.
- 6. Clinton JM: A case of congenital pericardio-peritoneal communication in a dog. J Am Vet Radiol, 8, 57-60, 1967. DOI: 10.1111/j.1740-8261.1967. tb01074.x
- 7. Torfs CP, Curry CJ, Bateson TF, Honore LH: A population-based study of congenital diaphragmatic hernia. Teratology, 46, 555-565, 1992. DOI: 10.1002/tera.1420460605
- 8. Suter PF: Abnormality of the diaphragm. In, Suter PF, Lord SF (Eds): Thoracic Radiography: A Text Atlas of Thoracic Diseases of Dog and Cat. 179-204, Wettswill, Switzerland, 1984.
- 9. Kastelein RA, vanDooren MF, Tibboel D: A case study of congenital diaphragmatic hernia in a juvenile striped dolphin (Stenella coeruleoalba). Aquatic Mammals, 35, 32-35, 2009. DOI: 10.1578/AM.35.1.2009.32
- 10. Dennis SM, Nairn ME: Two cases of congenital diaphragmatic hernia in Australian merino lambs. Vet Rec, 77, 754-756, 1965.
- 11. Fonteneau M: Congenital diaphragmatic hernias in cattle. Encycl Vet Period, 21, 23-27, 1964.
- 12. Karamanoukian HL, Glick PL, Wilcox DT, OToole SJ, Rossman JE, Azizkhan RG: Pathophysiology of congenital diaphragmatic hernia XI: Anatomic and biochemical characterization of the heart in the fetal lamb CDH model. J Pediatr Surg, 30 (7): 925-929, 1995.
- 13. Geggel RL, Murphy JD, Landleben D, Crone RK, Vacanti JP, Reid LM: Congenital diaphragmatic hernia: Arterial structural changes and persistent pulmonary hypertension after surgical repair. J Pediatr, 107, 457-464, 1985. DOI: 10.1016/S0022-3476(85)80534-5
- 14. Wu J, Yamamoto H, Gratacos E, Ge X, Verbeken E, Sueishi K, Hashimoto S, Vanamo K, Lerut T, Deprest J: Lung development following diaphragmatic hernia in the fetal rabbit. Hum Reprod, 15, 2483- 2488, 2000. DOI: 10.1093/humrep/15.12.2483
- 15. Harrison MR, Bressack MA, Churg AM, de Lorimier AA: Correction of congenital diaphragmatic hernia in utero. II. Simulated correction permits fetal lung growth with survival at birth. Surgery, 88, 260-268, 1980.
- 16. Thébaud B, Tibboel D, Rambaud C, Mercier JC, Bourbon JR, Dinh- Xuan AT, Archer SL: Vitamin A decreases the incidence and severity of nitrofen-induced congenital diaphragmatic hernia in rats. Am J Physiol Lung Cell Mol Physiol, 277 (2): 423-429, 1999.