Yeşim GÜROL, Rahmiye BERKİTEN, Apostolos GEORGOPOULOS

Alt solunum yolu infeksiyonlarından izole edilen Streptococcus pneumoniae suşlarının serotiplendirilmesi

Çocuk ve erişkin hastaların balgam örneklerinden izole edilen 44 S.pn'eumortiae susu Pneumotest ile serotiplendirilmiştir. Suşlar 19 serotipe dağılmış, beşer suşla 19F ve 6B, dörder suşla 4 ve 14 en sık rastlanan serogrup veya serotipler olmuş, kalan 26 suş 15 serotipe 1-3 sayılarda dağılmıştır. Bu serotiplerden 16F dışındaki tümü 23 değerlikli; en fazla saptanan 19F,6B,4 ve 14 serotipleri 7 değerlikli konjuge aşı içersinde yer almaktadır.

Anahtar Kelimeler:

Solunum yolu enfeksiyonları, Streptococcus pneumoniae, Serotiplendirme, Balgam

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1. Ayyıldız A, Kocazeybek B, Arıtürk S: Cerrahi yoğun bakım hastalarından infeksiyon etkeni olarak izole edilen Gram negatif çomaklarda aminoglikozid direnci, ANKEM Derg 2002;16:78.
2. Barr WH, Colucci R, Radwanski E et al: Pharmacokinetics of isepamicin, J Chemother 1995;7(Suppl 2):53.
3. Chan-Tack KM: Changing antibiotic sensitivity patterns at a university hospital, 1992 through 1999, South Med J 2001;94(6):619-20.
4. Covi M, Velluti G: Comparison of the efficacy and safety of isepamicin and amikacin in the treatment of acute lower respiratory tract infections caused by gram negative organisms, J Chemother 1995;7(Suppl 2):137-42.
5. Cunha BA: Pseudomonas aeruginosa: Resistance and therapy, Semin Respir Infect 2002;17(3):231-9.
6. Erdem B: Pseudomonaslar, “Ustaçelebi Ş (ed): Temel ve Klinik Mikrobiyoloji” kitabında s.551-8, Güneş Kitapevi, Ankara (1995).
7. Estahbanati HK, Kashani PP, Ghanaatpisheh F: Frequency of Pseudomonas aeruginosa serotypes in burn wound infections and their resistance to antibiotics, Burns 2002;28(4):340-8.
8. Günseren F, Mamıkoğlu L, Öztürk S et al: Surveillance study of antimicrobial resistance of gram-negative bacteria isolated from intensive care units in eight hospitals in Turkey, J Antimicrobial Chemother 1999;43(3): 373-8.
9. Gür D, Tutar İ, Vardar Ünlü G ve ark: İsepamisinin hastane izolatı Gram-negatif bakterilere karşı in vitro etkisi, Hastane İnfeksiyon Derg 2001;5(Ek 1):19-24.
10. Igumbor E, Gwanzura L, Chirara M, Obi C, Muza D: Antibiotic sensitivity and plasmid profiles of Pseudomonas aeruginosa, Afr J Med 2000;46 (11):296-300.
11. Landman D, Quale JM, Mayorga D et al: Citywide clonal outbreak of multiresistant Acinetobacter baumannii and Pseudomonas aeruginosa in Brooklyn, NY: the preantibiotic era has returned, Arch Intern Med 2002;162(13):1515-20.
12. Leal Del Rosal P: The efficacy and safety of isepamicin compared with amikacin in the treatment of intra-abdominal infections, J Chemother 1995;7(Suppl 2):143-8.
13. Mendeş H, Geyik MF, Kökoğlu ÖF, Haşoğlu S, Ayaz C: Hastane ve toplum kaynaklı gram negatif çomaklarda aminoglikozid direnci, X.Türk Klinik Mikrobiyoloji ve İnfeksiyon Hastalıkları Kongresi, Program kitabı s.268, Adana (2001).
14. Miller GH, Sabatelli FJ, Hare RS and The Aminoglycoside Resistance Study Group: The most frequent aminoglycoside resistance mechanisms-Changes with time and geographic area. A reflection of aminoglycoside usage patterns? Clin Infect Dis 1997;24(Suppl 1):46-62.
15. National Committee for Clinical Laboratory Standards: Performance Standards for Antimicrobial Disk Susceptibility Tests, NCCLS Document, sixth ed., Approved Standard M2-A5 (M100-S7), Wayne, Pa (2002).
16. O’hara K, Nakamura A, Sawai T et al: The resistance of recent clinical isolates against isepamicin, other aminoglycosides and injectable betalactams, Jpn J Antibiot 2000;53(1):46-59.
17. Över U, Gür D, Ünal S, Miller GH: Gram-negatif bakterilerde aminoglikozid antibiyotiklere karşı direnç mekanizmaları, Son gelişmeler ve Türkiye sonuçları, Flora 2000;5:168-78.
18. Rio Y, Pina P, Jurin F, Allouch P, Didion J, Chardon H, Chiche D: [Susceptibility of Pseudomonas aeruginosa to antibiotics isolated from patients of intensive care units in France in 1998. Resistant phenotypes to beta-lactams], ESCRIME Study, Pathol Biol (Paris) 2002;50(1):12-7.
19. Şahin İ, Şencan İ, Kaya D, Öksüz Ş, Yıldırım M: Yatan hastalardan ve poliklinik hastalarından izole edilen gram negatif bakterilerde isepamisin ve diğer aminoglikozidlere direnç, ANKEM Derg 2002;16(4):445-9.
20. Tasaka K, Ishida A, Chinzei T: Antimicrobial activity of carbapenems and the combined effect with aminoglycoside against recent clinical isolates of Pseudomonas aeruginosa, Jpn J Antibiot 2002;55(2):181-6.
21. Vanhoof R, Nyssen HJ, Van Bossuyt E, Hannecart-Pokarni E and Aminoglycosides Study Group: Aminoglycoside resistance in Gram negative blood isolates from various hospitals in Belgium and the Grand Duchy of Luxemburg, J Antimicrob Chemother1999;44:483.
22. Vigano A, Principi N: A randomized comparison of isepamicin and amikacin in the treatment of bacterial infections in pediatric patients, J Chemother 1995;7(Suppl 2):95-101.
23. Vincent P, Vachee A, Izard D: Sensitivity of Pseudomonas aeruginosa to amikacin and to isepamicin in surgery and in intensive care, Pathol Biol (Paris) 1997;45(9):771-5.