İbrahim EREN, Ali Metehan ÇALIŞKAN, Çivi İkbal İNANLI

Primer hiperparatiroidinin neden olduğu duygudurum bozukluğu: Olgu sunumu

Hiperparatiroidi parathormon yüksekliği ve buna bağlı olarak gelişen hiperkalsemi ve hipofosfatemi ile giden bir tablodur. Kalsiyum metabolizması bozukluklarında depresyondan deliryuma, hatta psikoza kadar gidebilen ciddi psikiyatrik bozukluklar görülebilmektedir. Biz bu yazıda hiperparatiroidinin neden olduğu bir majör depresyon benzeri nöbeti olan hasta sunduk. Hiperparatiroidizm ile eş zamanlı gelişen depresyon, antidepresan tedaviye yeterli yanıt vermemekteydi. Paratiroid adenomunun tedavisinin ardından hastanın depresif belirtileri tamamen ortadan kalktı. Kalsiyum iyonu nöron işlevleri ile direkt ilişkidir. Bu nedenle ciddi psikiyatrik tablolara neden olabilmektedir. Antidepresan ilaçların etkinliklerinde nörondaki kalsiyum kanallarına etkilerinin de rolü olduğu bilinmektedir. Aynı zamanda serum kalsiyumu da antidepresanlara yanıtı etkiliyor olabilir. Biz hastadaki iyileşmeyi etiyolojik etkenin ortadan kalkması ve serum kalsiyum düzeyinin antidepresan tedaviye yanıtı etkilemesi açısından değerlendirdik.

Anahtar Kelimeler:

Hiperparatiroidi, primer, Kadın, Duygudurum bozuklukları, Tedavi sonucu, Depresyon, Kalsiyum, Yaşlı

Mood disorder caused by hyperparatyroidism: case report

Hyperparathyroidism is a condition associated with an increase in PTH level resulting in hypercalcemia and hypophosphatemia. In the disorders of calcium metabolism serious psychiatric problems such as depression, delirium even psychosis can be seen. In this article we reported a patient who experienced a major depression like episode caused by hyperparathyroidism. Depression that occurs at the same time with hyperparathyroidism did not give adequate response to the antidepressive treatment. After the treatment of adenoma in the parathyroid glands the patient's depressive signs totally disappeared. The calcium ion is directly related to the neuronal functions. Thus it can cause serious psychiatric situations. In the efficacy of the antidepressive drugs, it is known that the calcium channels in the neurons play a role. In addition, the serum calcium level can affect the response to the antidepressive drugs. We evaluated the improvement of the patient in terms of the vanishing of the etiological reason and the effect of serum calcium levels on the response to the antidepressive treatment.

Keywords:

Hyperparathyroidism, Primary, Female, Mood Disorders, Treatment Outcome, Depression, Calcium, Aged,

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