HAYRİYE BAYKAN, Onur DURMAZ, ÖZGÜR BAYKAN, Murat ALIŞIK, Merve ŞAHİN CAN, TUNAY KARLIDERE, ÖZCAN EREL

Majör depresif bozukluk tanılı kadın hastalarda yeni bir oksidatif belirteç olarak tiyol/disülfid dengesi

Amaç: Bu çalışmada majör depresif bozukluğu olan kadın hastalarda oksidatif stres durumunu değerlendirmeyi amaçladık. Yöntem: Çalışmaya ilaç tedavisi görmeyen majör depresif bozukluğu olan 44 kadın hasta ve 68 sağlıklı kadın alındı. Sosyodemografik Form, Hamilton Anksiyete Derecelendirme Ölçeği, Hamilton Depresyon Derecelendirme Ölçeği (HAM-D) tüm örneklemlere uygulandı. Serum tiyol/disülfid düzeyleri tüm katılımcılardan alınmış açlık kan örnekleri değerlendirilerek ölçüldü. Bulgular: Serum native tiyol düzeyleri hasta grubunda kontrol grubuna göre anlamlı düzeyde daha yüksek saptanırken, serum disülfid düzeyleri anlamlı düzeyde daha düşük saptandı. Serum total tiyol düzeyleri açısından gruplar arasında anlamlı fark yoktu. Hasta grubunda serum disülfid/native tiyol ve serum disülfid/total tiyol oranları anlamlı düzeyde düşük iken, serum native tiyol/total tiyol oranı anlamlı düzeyde yüksek saptandı. Hastaların HAM-D puanı ve serum disülfid düzeyi, disülfid/native tiyol oranı, disülfid/total tiyol oranı arasında negatif korelasyon, HAM-D puanı ve serum native tiyol/total tiyol oranı arasında pozitif korelasyon vardı. Tartışma: Çalışmamız tedavisiz majör depresyon tanılı kadınlarda dinamik tiyol/disülfid dengesini inceleyen ilk çalışmadır. Çalışmamızın sonuçları tedavisiz majör depresyon tanılı kadınlarda dinamik tiyol/disülfid dengesinin antioksidatif bir reaksiyonu düşündürecek şekilde tiyol oluşumu yönünde olduğunu göstermiştir.

Dynamic thiol/disulphide homeostasis as a novel oxidative stress marker in women with major depressive disorder

Objective: We aimed to investigate the oxidative stress status in a population of women with untreated major depressive disorder. Methods: Fifty-four female patients with untreated major depressive disorder and 68 female healthy controls were included in the study. A Sociodemographic Form, the Hamilton Anxiety Rating Scale, and the Hamilton Depression Rating Scale (HAM-D) were applied to all the participants. Fasting blood samples were collected from all participants to assess serum thiol/disulphide levels and their pairwise ratios. Results: Native thiol levels were significantly higher and disulphide levels were lower in patients as compared to controls, while total thiol levels were not significantly different between the groups. Disulphide/native thiol and disulphide/total thiol ratios were significantly lower, while the native thiol/total thiol ratio was significantly higher, in the patient group than the control group. There was a negative correlation between HAM-D score and disulphide level, disulphide/native thiol ratio, and disulphide/total ratio, while there was a positive correlation between HAM-D score and native/total thiol ratio, in the patient group. Discussion: This is the first study to investigate dynamic thiol/disulphide homeostasis in women with untreated major depressive disorder. Our results showed dynamic thiol/disulphide homeostasis shifts towards thiol formation which implies an antioxidant reaction in women with untreated major depressive disorder.

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