Testis torsiyonu ve papaverin kullanımı
Testis torsiyonu, ani başlayan skrotal ağrılı, adolesan döneminde erkeklerde cerrahi gerektiren bir acildir. Tanının konulması ve en kısa sürede cerrahi yaklaşımın uygulanması testisin kurtarılmasını sağlamaktadır. Birçok çalışmada vazodilatatör, antioksidant gibi birçok ajan testis zararını azaltmak ve önlemek amaçlı denenmiştir. Papaverin bu ajanlardan bir tanesidir. 27 yaşında 12 saattir süren skrotal ağrı nedeniyle acile başvuran hasta hızlı bir şekilde değerlendirilip, testis torsiyonu ön tanısıyla cerrahiye alındı. Testis detorsiyone edildikten sonra renginde bir değişiklik olmadığı izlendi. Ardından korda papaverin enjeksiyonu yapıldı ve testis renginde ve dokusunda belirgin bir iyileşme izlendi. Bilateral orşiopeksi uygulanarak işlem sonlandırıldı
Testicular torsion and papaverın usage
Testicular torsion remains a common surgical emergency of adolescent males presenting with sudden onset of intense scrotal pain. Prompt recognition of the condition and immediate surgical intervention is the only hope for testicular salvage.And several studies have tested several agents such as vasodilators and antioxidants to inhibit or temper testicular damage. Papaverin is the one of these agents.A twenty-seven old patient presented with the torsion of testis twelve hours after induced torsion.Exploration had been prompt and testis was detorsioned, but colour of testis was not recover. After injection of papaverin the testis was gotten beter, so orchiopexy was done.
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- Tabriziani H, Frishman WH, Brandt LJ. Drug therapies for mesenteric vascular disease. Heart Dis 2002:4;306-14.
- Herskowitz M, Gilllego V, Ward M, et al. Cocaine induced mesenteric ischemia; treatment with intra-arteriel papave- rine. Emerg Radiol 2002:9;172-4.
- Sammartano RJ, Boley SJ, Kleinhaus S, Sprayragen S. Intra- arterial papaverine HCl in acute superior mesenteric arteri- al occlusion. Gastroenterology 2000:118:954- 968.
- Boley SJ, Sammartano RJ, Brandt LJ, et al. Intra-arteri- al vasodilators and thrombolytic agents in experimental superior mesenteric artery embolus. Gastroenterology 2000:118:954- 968.
- Shenkin HA. Effects of various drugs upon cerebral circula- tion and metabolism in man. J. Applied Physiol 1991:3:465- 471.
- Haggendal E. Effects of some vasoactive drugson the ves- sels of cerebral grey matter in the dog. Acta Physiol Scand 1995:66: 55-72.
- McHenry LC, Jaffe ME, Kawamura J, et al. The effect of pa- paverine on regional cerebral blood flow in focal vascular disease of the brain. New Eng J Med 1970:282: 1 167-1 170.
- Bird S. Failure to diagnose of testicular torsion. Aust Fam Physician 2003;32:527-8.
- Williamson RCN: Torsion of the testis and allied conditi- ons. Br J Surg 63: 465-476, 1976.
- Harrison RH: Testicular torsion. In Glenn JF( ed) : Uro- logic Surgery. Philadelphia, Toronto, JB Lippincott Co 1983,1067-1076.
- Smith DR: Disorders of the testis, scrotum and spermatic cord. In Smith DR (ed) : General Urology. Los Altos Cali- fornia, Lange Medical Publications 1981, 505-513.
- Pentyala S, Lee J, Yalamanchili P, Vitkun S, and Khan SA, Testicular torsion: a review. Journal of Lower Genital Tract Disease, vol. 5, no. 1, 2001: 38–47.
- Bartsch G, Frank ST, Marberger H, and Mikuz G, “Testicu- lar torsion: late results with special regard to fertility and en- docrine function. Journal of Urology vol. 124, no. 3, 1980: 375–378.
- Amelar RD, Dubin L, Walsh PC. Male infertility. Philadelp- hia, London, Toronto, WB Saunders Co 1977:79-190, 215- 236.
- Mehmet K ,Hakan Y. Acute Mesenterıc Ischemia Klinikleri J Surg Med Sci 2005:1:17-23.
- Marteau P, Ballet F, Chazouilleres O, et al. Effect of vasodi- lators on hepatic microcirculation in cirrhosis: a study in theisolated perfused rat liver. Hepatology 1989: 9:820-3.
- Chazouilleres O, Ballet F, Chretien Y, et al. Protective effect of vasodilators on liver function after long hypothermic preservation: a study in the isolated perfused rat liver. He- patology 1989: 9:824-9.