Burçin ÇELİK, Ekber ŞAHİN, Aydın NADİR, Şahande ELAGÖZ, Şinasi MANDUZ, Şule KARADAYI, Yücel AKTAŞ, Melih KAPTANOĞLU

The effects of chlorhexidine gluconate and silver nitrate on rabbit lung: An experimental study

Amaç: Bu çalışmada klorhekzidin glukonat ve gümüş nitratın akciğerler üzerine olan etkisi incelendi ve akciğer kist hidatik ameliyatlarında kullanılabilirliği değerlendirildi.Çalışma planı: Çalışmada ağırlıkları 2750 ile 3000 gram arasında değişen otuz sağlıklı Wistar albino Yeni Zelanda tavşanı kullanıldı ve tavşanlar üç gruba ayrıldı. Birinci grupta serum fizyolojik, ikinci grupta %0.5’lik gümüş nitrat ve üçüncü grupta %0.04’lük klorhekzidin glukonat trakea yoluyla verildi. İşlemden 30 gün sonra tavşanlardaki trakeobronşiyal ve parenkimal değişiklikler histopatolojik olarak incelendi. Trakeobronşiyal değişiklikler trakeal patolojiye göre değerlendirildi, oysa peribronşiyal lenfositik infiltrasyon ve parenkimal değişiklikler ise interstisyel lenfositik infiltrasyon, kanama-ödem, fibrozis ve pnömoni açısından değerlendirildi.Bulgular: İnterstisyel lenfositik infiltrasyon oranı klorhekzidin glukonat grubunda kontrol grubuna göre daha yüksek iken, fibrozis ve fibrin birikimi gümüş nitrat grubunda kontrol grubuna göre daha yüksekti. Gruplar arasında diğer parametrelerde istatistiksel açıdan anlamlı farklılık bulunmadı.Sonuç: Çalışmanın sonuçları ile %0.04’lük klorhekzidin glukonatın tavşan akciğeri ve trakeobronşiyal mukoza üzerine minimal negatif bir etkisinin olduğu ve gümüş nitrata göre daha güvenilir bir ajan olduğu gösterilmiştir.

Klorhekzidin glukonat ve gümüş nitratın tavşan akciğeri üzerindeki etkileri: Deneysel bir çalışma

Background: In this study, we investigated the effects of chlorhexidine gluconate and silver nitrate on the lungs and determine their utility in operations for pulmonary hydatid cysts.Methods: Thirty New Zealand Wistar albino rabbits weighing between 2750 and 3000 grams were used in the study and divided into three groups. In the first (control) group, normal saline (0.09% NaCl); in the second group, silver nitrate (0.5%); and in the third group, chlorhexidine gluconate (0.04%) was administered intrathraceally. Thirty days after the procedure, the tracheobronchial and parenchymal changes in the subjects were evaluated histopathologically. Tracheobronchial changes were evaluated with respect to tracheal pathology whereas peribronchial lymphocytic infiltration and parenchymal changes were evaluated with respect to interstitial lymphocytic infiltration, hemorrhage-edema, fibrosis and pneumonitis.Results: The rate of interstitial lymphocytic infiltration was higher in the chlorhexidine gluconate group than in the control group, and the rates of fibrosis and fibrin accumulation were higher in the silver nitrate group than in the control group. No statistically significant differences in other parameters were found between the groups.Conclusion: The results of the study indicate that chlorhexidine gluconate (0.04%) has minimal negative effects on the rabbit lung and tracheobronchial mucosa and is a more reliable agent than silver nitrate.

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