Kürşat KARGÜN, Sefa ŞENOL, Mustafa YILDIZ, Murat KARA, Hayrettin TEKÜMİT

Adiponectin and leptin polymorphisms in patients with coronary artery disease

Amaç: Bu çalışmada, koroner arter baypas greft (KABG)cerrahisi yapılacak hastalarda adiponektin ve leptin genpolimorfizmleri analiz edildi. Çalışmaplanı: Ocak 2012 - Nisan 2013 tarihleri arasındaçalışma grubunda koroner arter hastalığı (KAH) nedeniyleKABG yapılması planlanan toplam 110 hasta (78 erkek, 32 kadın;ort. yaş 61.3±7.8 yıl; dağılım 47-76 yıl) ve kontrol grubundaKAH olmayan 96 sağlıklı birey (68 erkek, 28 kadın; ort. yaş59.4±8.3 yıl; dağılım 46-78 yıl) çalışmaya dahil edildi. Bul gu lar: Adiponektin rs2241766 gen polimorfizmi ve allelgörülme sıklığı, çalışma grubunda istatistiksel olarak anlamlıdüzeyde daha düşüktü (p

Koroner arter hastalarında adiponektin ve leptin polimorfizmleri

Background: In this study, adiponectin and leptin genepolymorphism were analyzed in patients with planned coronaryartery bypass graft (CABG) surgeries. Methods: Between January 2012 and April 2013, 110 patients inthe study group (78 males, 32 females; mean age 61.3±7.8 years;range 47 to 76 years) were scheduled for CABG surgery forcoronary artery disease (CAD) and 96 healthy subjects withoutCAD in the control group (68 males, 28 females; mean age59.4±8.3 years; range 46 to 78 years) were included in the study. Results: Adiponectin rs2241766 gene polymorphism and allelefrequency were statistically significantly lower in the studygroup (p

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