OM KOLAWOLE, KT OLATUNJİ, KA DUROWADE, AA ADENİYİ, LO OMOKANYE

Güney batı Nijerya'da bir üçüncü basamak sağlık kuruluşuna başvuran kadınlar arasında pap smear testi paterni, human papilloma virus infeksiyonu prevalansı ve risk faktörleri

Serviks kanseri son on yılda Nijeryalı kadınlar arasında artmaktadır ve kanser ölümlerinin en önemli ikinci nedenidir. Bu çalışmada Güneybatı Nijerya'da üçüncü basamak bir sağlık tesisinin jinekoloji servisinde takip edilen kadın kohortunda prevalans, HPV enfeksiyonu için risk faktörleri ve Papanicolaou simir testi sonuçlarının belirlenmesi amaçlanmıştır. Yöntem: Bu araştırma, PAP simir testi ile taranan ve IgG ELIZA testi ile servikal intraepitelyal neoplazi taramasına katılan, 15-64 yaş grubu kadınlarda yapılmış kesitsel tipte bir çalışmadır. Katılımcılar duruma uygun örnekleme ile seçildi. Veri toplamak için görüşmeci tarafından soru formu yüz yüze uygulandı ve klinik kayıtlar kullanıldı. Veriler SPSS version 17 kullanılarak analiz edildi. Bulgular: HPV enfeksiyonu için analiz edilen 200 kan örneğinden 135 (%67,5)'i seropositif iken 65 (%32,5)'i seronegatifti. Servikal sitoloji için yapılan PAP simirlerden 14 (%7)'ü positif iken (servikal anormallik var) 186 (%93)'sı negatif (servikal anormallik yok) idi. Sonuçlar seropozitivite, servikal intraepitelyal neoplazi and HPV enfeksiyonu arasında doğrudan bir ilişkiyi gösterdi. HPV enfeksiyonu gelişmi için risk faktörleri yaş, evlilik tipi, parite, genital enfeksiyon öyküsü ve tütün kullanımını içeriyordu. Erkeğin sünnetsiz olması da risk faktörü olarak bulundu. Sonuç: Anormal servikal sitoloji varlığı ve yüksek düzeyde serolojik pozitiflik, taramaya, aşılama yöntemlerine ve erken HPV taramasına bütüncül bir yaklaşımın gerekli olduğunu açıkça göstermiştir

Prevalence, risk factors of human papillomavirus infection and papanicolaou smear pattern among women attending a tertiary health facility in south-west Nigeria

Cervical cancer amongst Nigerian women has been on the increase in the past decade, and is regarded as the second highest cause of cancer deaths among Nigerian women. This study was aimed at determining the prevalence, risk factors of HPV infection, and Papanicolaou smear pattern amongst a cohort of women attending the Gynaecology clinic of a tertiary health facility in Ido-Ekiti, South west Nigeria. Method: This was a cross-sectional study involving the screening of women between the ages of 15-64 years for cervical intraepithelial neoplasia using Papanicolaou smear staining technique and serological diagnosis using IgG enzyme linked immunosorbent assay kits. Respondents were selected through convenience sampling of subjects, while interviewer- administered questionnaire and clinical report form were also used to collect data, and data was analyzed using SPSS version 17. Results: Of the 200 blood samples examined for Human papillomavirus infection, 135 (67.5%) were sero-positive while 65 (32.5%) were sero-negative. For cervical cytology using Papanicolaou smear, 14 (7%) were positive (had presence of cervical abnormality) while 186 (93%) were negative (had no cervical abnormality). Result showed a direct relationship between seropositivity, development of cervical intraepithelial neoplasia and Human papillomavirus infection. The risk factors for the development of HPV infection included age, type of marriage, parity, history of genital infection and tobacco usage. Non circumcision of male partner was also found to be a risk factor. Conclusion: The presence of abnormal cervical cytology and high level of serological positivity clearly showed why there is need for a holistic approach to the screening, vaccination methodologies and early detection of HPV infection in the country

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