Atopik Dermatitli hastalarda gıda allerjileri

Atopik Dermatit (AD) kronik, tekrarlayıcı karakterde, gıda ve solunum yolu allerjilerinin sıklıkla eşlik ettiği, inflamatuvar bir deri hastalığıdır. Gıdaların AD etyolojisinde oynamış olduğu rol tartışılmaktadır. Hastaların ebeveynlerinin %90’ından fazlası ile birinci basamak hekimlerinin %60’ı, AD’nin gıda allerjilerinden kaynaklandığını düşünmektedir. Ancak AD’yi alevlendirebilecek gıdaları ortaya çıkarmak zordur. Bu yazıda, AD ile gıda allerjileri arasındaki ilişki gözden geçirilmiştir.

Food allergies in patients with atopic dermatitis

Atopic Dermatitis (AD) is a chronic, relapsing, inflammatory skin disease, associated with food and inhalant allergies. The relationship between food and AD is controversial. Greater than 90% parents and 60 % of primary care providers considers that food allergies as the cause for AD. However, it is difficult to reveal that food aggravating AD. In this article the relationship between AD and food allergy was reviewed.

___

  • 1.Spergel JM, Paller AS. Atopic dermatitis and the atopic march. J Allergy Clin Immunol. 2003; 112: 118-27.
  • 2.Werfel T, Breuer K. Role of food allergy in atopic dermatitis. Curr Opin Allergy Clin Immunol. 2004; 4(5): 379-85.
  • 3. Fuiano N, Incorvaia C. Dissecting the causes of atopic dermatitis in children: less foods, more mites. Allergol Int. 2012; 61(2): 231-243.
  • 4. Suh KY. Food allergy and atopic dermatitis: separating fact from fiction. Semin Cutan Med Surg. 2010; 29(2): 72-78.
  • 5. Johnston GA, Bilbao RM, Graham-Brown RA. The use of dietary manipulation by parents of children with atopic dermatitis. Br J Dermatol. 2004; 150: 1186–1189.
  • 6. Werfel T, Ballmer-Weber B, Eigenmann PA, Niggemann B, Rancé F, Turjanmaa K, Worm M. Eczematous reactions to food in atopic eczema: position paper of the EAACI and GA2LEN. Allergy. 2007; 62(7): 723–728.
  • 7. Waard-van der Spek FB de, Oranje AP. Contact urticaria syndrome and childhood atopic dermatitis. In: Amin S, Lahti A, Maibach HI, eds. Contact Urticaria Syndrome, New York, CRC Press. 1997, p. 261–266.
  • 8. Breuer K, Wulf A, Constien D, et al. Birch-pollen related food as a provocation factor of allergic symptoms in children with atopic eczema / dermatitis syndrome. Allergy. 2004; (59): 988– 994
  • 9.Worm M, Forschner K, Lee H, et al. Frequency of Atopic Dermatitis and Relevance of Food Allergy in Adults in Germany. Acta Derm Venereol. 2006; 86: 119–122.
  • 10. Sicherer SH, Sampson HA. Food hypersensitivity and atopic dermatitis: pathophysiology, epidemiology, diagnosis, and management. J Allergy Clin Immunol. 1999; 104: 114-22.
  • 11. Burks W. Skin manifestations of food allergy. Pediatrics. 2003; 11: 617–624.
  • 12. Nickel R, Kulig M, Forster J, et al. Sensitization to hen’s egg at the age of twelve months is prdictive for allergic sensitization to common indoor and outdoor allergens at the age of three years. J Allergy Clin Immunol. 1997; 99: 613– 617.
  • 13. Oranje AP, Wolkerstorfer A, de Waard-van der Spek FB. Natural course of cow’s milk allergy in childhood atopic syndrome. Ann Allergy 2002; 89: 52–55. eczema/dermatitis Asthma Immunol.
  • 14. Leung DY, Boguniewicz M, Howell MD, Nomura I, Hamid QA. New insights into atopic dermatitis. J Clin Invest. 2004; 113: 651–657.
  • 15. Strachan DP. Hay fever, hygiene and household size. BMJ. 1989; 299: 1259–1260.
  • 16. Guillet G, Guillet MH. Natural history of sensitizations in atopic dermatitis. A 3-year follow-up in 250 children: food allergy and high risk of respiratory symptoms. Arch Dermatol. 1992; 128(2): 187-192.
  • 17. Han DK, Kim MK, Yoo JE, Choi SY, Kwon BC, Sohn MH, Kim KE, Lee SY. Food sensitization in infants and young children with atopic dermatitis. Yonsei Med J. 2004; 45(5): 803-809.
  • 18. Burks AW, Mallory SB, Williams LW, Shirrell MA. Atopic dermatitis: clinical relevance of food hypersensitivity reactions. J Pediatr. 1988; 113(3): 447-451.
  • 19. Hill DJ, Hosking CS, de Benedictis FM, Oranje AP, Diepgen TL, Bauchau V; EPAAC Study Group. Confirmation of the association between high levels of immunoglobulin E food sensitization and eczema in infancy: an international study. Clin Exp Allergy. 2008; 38(1): 161-168.
  • 20. Taşkapan O. Besin Allerjileri ve Atopik Dermatit. Türkiye Klinikleri J Int Med Sci. 2006; 2(41): 32- 40.
  • 21. Reekers R, Beyer K, Niggemann B, et al. The role of circulating food antigen-specific lymphocytes in food allergic children with atopic dermatitis. Br J Dermatol. 1996; 135: 935–941.
  • 22. Werfel T, Ahlers G, Schmidt P, et al. Milk- responsive atopic dermatitis is associated with a casein-specific lymphocyte response in adolescent and adult patients. J Allergy Clin Immunol. 1997; 99: 124–133.
  • 23. Sampson HA, Scanlon SM. Natural history of food hypersensitivity in children with atopic dermatitis. J Pediatr. 1989; 115: 23–27.
  • 24. Sampson HA, McCaskill CC. Food hypersensitivity and atopic dermatitis: Evaluation of 113 patients. J Pediatr. 1985; 107: 669–675.
  • 25. Ortolani C, Ispano M, Pastorello EA, et al. Comparisonof results of skin prick tests (with fresh foods and commercial food extracts) and RAST in 100 patients with oral allergy syndrome. J Allergy Clin Immunol. 1989; 83: 683–690.
  • 26. Turjanmaa K, Darsow U, Niggemann B, Ranc F, Vanto T, Werfel T. EAACI/GA2LEN Position paper: Present status of the atopy patch test. Allergy 2006: 61: 1377–1384.
  • 27. Roehr CC, Reibel S, Ziegert M, et al. Atopy patch tests, together with determination of specific IgE levels, reduce the need for oral food challenges in children with atopic dermatitis. J Allergy Clin Immunol 2001; 107: 548–553.