Yusuf ÖNLEN, Cenk BABAYİĞİT, Ömer EVİRGEN, Şule ŞAHİN, Adnan Burak AKÇAY, Vicdan KÖKSALDI MOTOR

Pandemik influenza A (H1N1) hastalarının klinik özellikleri

Amaç: Mart 2009’da Meksika ve ABD’de ilk kez görülen bir influenza tipi olan A (H1N1) hızla tüm dünyaya yayılmış ve Ekim-Aralık aylarında tüm Türkiye’de etkili olmuştur. Bu çalışmada, hastanemizde influenza A (H1N1) tanısı ile yatarak tedavi edilen hastalarımızın klinik özelliklerini değerlendirmeyi amaçladık. Gereç ve Yöntem: Kasım-Aralık 2009 tarihlerinde Enfeksiyon Hastalıkları, Göğüs Hastalıkları ve Kardiyoloji servislerinde influenza benzeri semptomlarla yatarak tedavi gören 41 hasta retrospektif olarak değerlendirildi. H1N1 testi Refik Saydam Hıfzıssıhha Merkez Laboratuarında yapıldı. Bulgular: Çalışmaya alınan 41 hastanın 19’unda (%46.3) H1N1 testi pozitif iken 22’sinde (%53.7) negatif idi. Bu hastaların 19’u (%46.3) erkek, 22’si (%53.7) kadındı ve yaşları 16-75 (ortalama 32,1 (±14.7) idi. Kadın hastaların 8’i (%36.4) hamile, 14’ü (%63.6) hamile değildi. Hastalarımız genel olarak tedaviye iyi cevap verdiler. H1N1 testi pozitif iki hamile hastamızın kliniği çok ağır seyretti. Yoğun bakımda takip edilen hastalardan birisi tedaviye cevap vermedi ve Akut Solunum Yetmezliği Sendromu nedeniyle kaybedildi. Sonuç: Pandemik influenza A (H1N1) alt solunum yollarını mevsimsel influenzaya göre daha sık tutmaktadır. Hastalık genel olarak kısa süreli bir klinik gidişe ve hamileler dışında iyi bir prognoza sahip olmasına rağmen, hamilelerde ölümcül olabilmektedir.

Clinical characteristics of the patients with pandemic influenza A (H1N1)

Introduction: Influenza A (H1N1) was observed in Mexico and the United States for the first time in March 2009. It has spread to the whole world, quickly. It has been seen also in allover Turkey between October and December 2009. In this study, we aimed to evaluate the clinical characteristics of hospitalized patients with diagnosis of influenza A (H1N1). Material and Method: Retrospectively, 41 patients with influenza-like symptoms reviewed in Infectious Diseases, Chest Diseases, and Cardiology Services between November and December 2009. H1N1 test was performed in the Refik Saydam Hıfzıssıhha Central Laboratory. Results: Nineteen of 41 patients (46.3%) tested as positive for H1N1, while 22 (53.7%) were negative. Nineteen of these patients (46.3%) were male and 22 (53.7%) were female, and age distribution was 16-75 (mean 32.1 (± 14.7). Eight female patients (36.4%) were pregnant and 14 (63.6%) were not. Patients generally responded well to treatment. The prognosis was poor in two pregnant patients with H1N1 positivity. One of the patients did not respond to treatment in intensive care unit and died because of adult respiratory distress syndrome. Conclusion: Pandemic influenza A (H1N1) affects the lower respiratory tract more often than the seasonal influenza. Generally, this disease has a short-term clinical course with a good prognosis except for the pregnant women, in whom it may be fatal.

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