Aydın ÇİFCİ, Atilla Halil ELHAN, Filiz ÇİMEN, Nevin Taci HOCA, Serhat BİRENGEL, Salih CESUR, Gülnur TARHAN

Akciğer Kanseri ve Pnömoni Olgularında Serum Neopterin Düzeyleri

Amaç: Neopterin, hücre aracılıklı immün yanıtı gösteren duyarlı bir belirteçtir. Bu nedenle T hücreleri ve makrofaj- ların rol oynadığı çeşitli infeksiyon hastalıklarında vücut sıvılarında neopterin düzeylerinin belirlenmesi hücre aracı- lıklı immün yanıt hakkında bilgi sağlar. Kanser ve pnömoni hastalarında serum neopterin düzeylerinin yüksek oldu- ğu bildirilmiştir. Bu çalışmanın amacı, akciğer kanseri olan hastalar ve pnömonili hastalarda serum neopterin düzey- lerinin tanısal değerinin araştırılmasıydı.Yöntem ve Gereçler: Bu çalışmada, 24 pnömonili hasta (10 K, 14 E) , 20 akciğer kanserli hasta (20 E) ve 16 sağ- lıklı gönüllüde (5 K, 11 E) serum neopterin düzeyleri istatistiksel olarak karşılaştırıldı. Neopterin düzeyleri üreticifirmanın önerilerine göre ELISA yöntemiyle belirlendi. İstatistiksel değerlendirmede SPSS 11.5 programı kullanıldı.İstatistiksel analizlerde, univarite varyans analizi, kovaryans analizi ve Student T testler kullanıldı. p ≤ 0.05 değeriistatistiksel olarak anlamlı kabul edildi.Bulgular: Serum neopterin düzeyleri ortalaması sırasıyla; akciğer kanserli hastalarda 22.21 ± 8.60 nmol/l, pnömonilihastalarda 21.18 ± 8.76 nmol/l, kontrol grubunda ise 9.03 ± 4.15 nmol/l olarak belirlendi. Serum neopterin düzey- leri akciğer kanseri ve pnömoni hastalarında kontrol grubundan istatistiksel olarak anlamlı oranda yüksek saptandı.Serum neopterin düzeyleri kanserli hastalar ve pnömonili hastalar arasında istatistiksel olarak anlamlı farklılık gös- termedi.Sonuç: Serum neopterin düzeylerinin akciğer kanseri ve pnömonili hastalarda tanıda yardımcı test olarak kullanıla- bileceği, ancak; bu iki hastalığın birbirinden ayrımında kullanılamayacağı sonucuna varıldı.

Serum Neopterin Level In Patients With Lung Cancer And Case Of Pneumoniae

Aim:Neopterin is a sensitive marker for cell-mediated immune response. Because of this, the neopterin levels of bodyfluids show cell-mediated immune response in different infectious diseases which involve T cells and macrophages.It is reported that serum neopterin levels were found to be higher in patients with pneumoniae and patients with can- cer. The aim of this study was to investigate that the diagnostic value of neopterin in patients with lung cancer andpneumoniae.Material And Methods:In the present study, serum neopterin levels were compared between , 24 patients with pneu- moniae (10 female, 14 male) , 20 patients with lung cancer (20 male) and 16 healthy volunteers (5 female, 11 male).Neopterin concentrations were measured by ELISA method according to the protocol of manufacturer. In statisticalevaluation, SPSS 11.5 programme was used.Univariate analysis of variance, covariance analysis and Student t testswere used in statistical analysis. p value ≤0.05 and p ≤0.001 was accepted as statistical significant.Results:Serum neopterin levels were found to be 22.21 ± 8.60 nmol/l, 21.18 ± 8.76 nmol/l, and 9.03 ± 4.15 nmol/lin patients with lung cancer, pneumoniae and control groups, respectively. Serum neopterin levels were establishedto be significantly higher in patients with lung cancer and patients with pneumoniae than in control groups. Serumneopterin levels were not significantly different between patients with lung cancer and patients with pneumoniae.Conclusion:It is our suggestion that serum neopterin levels may be used as a supplementtary test in diagnosis in pa- tients with lung cancer and patients with pneumoniae but it can not be used in in differential diagnosis of these twodiseases.

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