The effects of ginseng and echinacea on some plasma cytokine levels in rats

Bu çalışmada sağlıklı ratlarda ginseng ve ekinezyanın IL-10, TGF-β1, TNF-α’nın plazma seviyeleri üzerine etkilerinin belirlenmesi amaçlanmıştır. Araştırmada 48 erkek Fischer 344 sağlıklı rat kullanıldı. Hayvanlar Kontrol (K), Ginseng (G) ve Ekinezya (E) olmak üzere üç eşit gruba ayrıldı. Kontrol grubundaki hayvanlar 40 gün süre ile standart rat yemi (Purina®) ile ad libitum olarak beslenirken, G grubundaki hayvanlara 0.5 g/kg yem olacak şekilde Panax ginseng, E grubundaki hayvanlara ise 0.75 g/kg yem olacak şekilde Ekinezya içeren aynı yem verildi. 20. ve 40. gün sonunda IL-10, TGF-β1 ve TNF-α plazma düzeyleri belirlendi. Çalışmada 20. gün belirlenen plazma IL-10 düzeyi ginseng grubunda kontrol ve ekinezya grubuna göre yüksekti (P

Anahtar Kelimeler:

Panax ginseng, kan plazması, sitokin, diyetler, bağışıklık sistemi, interleukin 10, sıçan, dönüştürücü büyüme etkeni, tümör nekroz faktör

Ginseng ve ekinezyanın ratlarda bazı plazma sitokin düzeyleri üzerine etkileri

In this study, it was aimed to determine the effects of ginseng and echinacea on plasma levels of IL-10, TGF-β1, TNF-α in healthy rats. In this research, 48 male Fischer 344 rats were divided into three equal groups as Control (K), Ginseng (G) and Echinacea (E). The control group were fed the standart rat diet (Purina®) as ad libitum for 40 days, whereas G and E groups animals received the same diet containing 0.5 g/kg Panax ginseng and 0.75 g/kg Echinacea purpurea, respectively. At 20th and 40th days, plasma levels of the IL-10, TGF-β1, TNF-α were assessed. At the 20th day, plasma IL-10 level in the ginseng group was higher (P<0.05) compared to the control and the echinacea group. There was no difference among the sampling times and the groups in concern with TGF-β1 level. At the 20th day, TNF-α level was higher (P<0.05) in the echinacea group than those of the ginseng and the control group. At the 40th day, TNF-α level in the echinacea group was higher (P<0.05) than the control group. In this study, the increases in IL-10 level with ginseng application and in TNF-α level in the echinacea group have supported the view of these plants modulate the immune system. However, it requires to make more detailed study about the effects of these plants on these cytokines.

Keywords:

Panax ginseng, blood plasma, cytokines, diets, immune system, interleukin 10, rats, transforming growth factor, tumour necrosis factor,

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