Sokak Köpeklerinde Spesifik Olmayan Reaktif Hepatit Çalışması
Bu çalışmanın amacı, Endülüs’ün (İspanya) farklı şehirlerinden toplanmış olan barınak köpeklerine ait doku örneklerinde Spesifik Olmayan Reaktif Hepatitin (NSRH) olası nedenlerini araştırmaktı. Hastalık, histolojik olarak, hepatosit nekrozu bulgusu olmadan, karaciğer parankimi boyunca ve portal stroma içinde yayılan lenfositlerin ve plazma hücrelerinin varlığı ile karakterize edildi. İncelenen hayvanlarda, derecesi orta ila şiddetli arasında değişen, spesifik olmayan kronik reaktif hepatit belirlendi. Görülme oranı yönünden değerlendirildiğinde, NSRH ile ilişkili olarak en sık görülen patolojiler gastrointestinal problemler ve böbrek hastalıklarının yanı sıra parazitik veya bulaşıcı kökenli pnömonilerdi.
Study of Non-Specific Reactive Hepatitis in Stray Dogs
The purpose of this paper was to study the possible causes of Non-Specific Reactive Hepatitis (NSRH) in tissue samples of housed dogs thatwere collected from diffrent cities of Andalucia (Spain). Histologically, this disease was characterized by the presence of lymphocytes andplasma cells spread throughout the liver parenchyma and in the portal stroma, with no evidence of hepatocyte necrosis. These animalsshowed non-specific chronic reactive hepatitis that varied from moderate to severe. In order of prevalence, the more common pathologiesassociated with NSRH were gastrointestinal and renal diseases, as well as pneumonia mainly of parasitic or infectious origin.
___
- 1. Hiemstra S, Harkema L, Wiersma LCM, Keesler RI: Beyond parasitism:
Hepatic lesions in stranded harbor porpoises (Phocoena phocoena)
without trematode (Campula oblonga) infection. Vet Pathol, 52, 1243-
1249, 2015. DOI: 10.1177/0300985814560233
- 2. Rothuizen J, Van Den Ingh TS: Hepatitis in dogs: A review. Tijdschr
Diergeneeskd, 123, 246-252, 1998.
- 3. Cullen J: Liver, Biliary System, and Exocrine Pancreas. In, McGavin M,
Zachary J (Eds): Pathologic Basis of Veterinary Disease. 4th ed., 393-461,
Mosby, Elsevier, Missouri, 2007
- 4. Cullen J, Stalker M: Liver and Biliary System. In, Jubb K, Kennedy P,
Palmer N (Eds): Pathology of Domestic Animals. 6th ed., Vol. 2, 258-352,
Academic Press Inc. California, 2016.
- 5. De Liberato C, Berrilli F, Odorizi L, Scarcella R, Barni M, Amoruso
C, Scarito A, Filippo MMD, Carvelli A, Iacoponi F, Scaramozzino P:
Parasites in stray dogs from Italy: Prevalence, risk factors and management
concerns. Acta Parasitol, 63, 27-32, 2018. DOI: 10.1515/ap-2018-0003
- 6. Piratae S, Pimpjong K, Vaisusuk K, Chatan W: Molecular detection of
Ehrlichia canis, Hepatozoon canis and Babesia canis vogeli in stray dogs in
Mahasarakham province, Thailand. Ann Parasitol, 61, 183-187, 2015. DOI:
10.17420/ap6103.05
- 7. Castanheira P, Duarte A, Gil S, Cartaxeiro C, Malta M, Vieira S,
Tavares S: Molecular and serological surveillance of canine enteric
viruses in stray dogs from Vila do Maio, Cape Verde. BMC Vet Res, 10:91,
2014. DOI: 10.1186/1746-6148-10-91
- 8. MacSween RNM: Pathology of the Liver. 4th ed., 828, Churchill
Livingstone London. New York, 2002.
9. Neumann S, Danner W: Reactive hepatitis in dogs. Glob Vet, 9, 454-
459, 2012.
- 10. Jaber JR, Pérez J, Arbelo M, Andrada M, Hidalgo M, GómezVillamandos JC, Van den Ingh T, Fernández A: Hepatic lesions in
cetaceans stranded in the Canary Islands. Vet Pathol, 41, 147-153, 2004.
DOI: 10.1354/vp.41-2-147
- 11. Jaber JR, Pérez J, Carrascosa C, Carballo M, Fernández A: Nonspecific reactive hepatitis in dolphins stranded in the Canary Islands. J
Appl Anim Res, 41, 398-403, 2013. DOI: 10.1080/09712119.2013.787363
- 12. Van Den Ingh T, Cullen J, Twedt D: Morphological classification of
biliary disorders of the canine and feline liver. In, Rothuizen J, et al. (Eds):
WSAVA Standards for Clinical and Histological Diagnosis of Canine and
Feline Liver Diseases. 61-76, Saunders Elsevier. Philadelphia, 2006.
- 13. Healey CJ, Chapman RWG, Fleming KA: Liver histology in hepatitis
C infection: A comparison between patients with persistently normal or
abnormal transaminases. Gut, 37, 274-278, 1995.
- 14. Bogunović D, Stević N, Sidi-Boumedine K, Mišić D, Tomanović
S, Kulišić Z, Magaš V, Radojičić S: Molecular evidence of Q fever agent
Coxiella burnetii in Ixodid ticks collected from stray dogs in Belgrade
(Serbia). Acta Vet Beograd, 68, 257-268, 2018. DOI: 10.2478/acve-2018-0023
- 15. Demirer AA, Akkoç A, Senlik B, Cangül IT: Severe granulomatous
hepatitis caused by Capillaria hepatica in a puppy. Turk J Vet Anim Sci, 42,
496-499, 2018. DOI: 10.3906/vet-1804-84