Alpaslan COŞKUN, HASAN GÜZELBEKTEŞ, Özlem EKİCİ DERİNBAY, UĞUR AYDOĞDU, İSMAİL ŞEN

Acute phase proteins, clinical, hematological and biochemical parameters in dairy cows naturally ınfected with anaplasma marginale

Bu çalışmanın amacı Anaplasma marginale ile doğal enfekte sığırlarda haptoglobin ve serum amyloid-A konsantrasyonlarında meydana gelen değişimleri belirleyerek akut faz cevabı değerlendirmektir. Çalışmanın ikinci amacı ise anaplazmozisli ineklerde gözlenen klinik, hematolojik ve biyokimyasal değişimleri belirlemektir. Araştırmaya anaplasmosis tanısı konulmuş 40 sütçü inek ve sağlıklı 10 sütçü inek dahil edildi. Çalışmada akut faz proteinlerin ölçümü, hematolojik ve biyokimyasal parametrelerin analizleri yapıldı. Enfekte gruptaki ineklerin serum haptoglobin ve serum amyloid-A konsantrasyonları kontrol grubundaki sığırlardan önemli ölçüde yüksek bulundu. Anaplasma marginale ile enfekte olan gruptaki tüm hayvanlar da anaplazmozisin klinik semptomları tespit edildi. Enfekte ineklerdeki serum aspartat aminotransferaz, alkalen fosfataz, kreatinin ve bilirubin konsatrasyonları kontrol grubuna göre önemli oranda yüksek tespit edilirken eritrosit sayısı, hematokrit değeri ve hemoglobin konsantrasyonu ise önemli oranda düşük olarak belirlendi. Sonuç olarak, anaplasmosisli sığırlarda, hematojik ve biyokimyasal değişiklikler aneminin ve doku hasarının bir göstergesi olabilir. Anaplasma marginale ile enfekte sığırlarda gelişen akut faz cevabın değerlendirilmesinde serum haptoglobin ve serum amyloid-A konsantrasyonları kullanılabilir.

Anahtar Kelimeler:

haptoglobin, Anaplasma marginale, akut faz proteinleri, alkalin fosfotaz, amiloyit, anaplazmozis, aspartat aminotransferaz, bakteriyel hastalıklar, bilirubin, kan kimyası, sığır, klinik görünüm, inek, kreatinin, süt sığırı, alyuvar sayısı, hematokrit, hematoloji, hemoglobin

Anaplasma marginale ile doğal enfekte sütçü ineklerde akut faz proteinler ile klinik, hematolojik ve biyokimyasal parametrelerin değerlendirilmesi

The aim of the study was to evaluate acute phase response via Haptoglobin and serum amyloid-A concentrations in dairy cows naturally infected with Anaplasma marginale. The second aim of the study was to determine the changes in clinical, hematological and biochemical parameters in dairy cows naturally infected Anaplasma marginale. A total of 40 dairy cattle suffering from bovine anaplasmosis were included to the study from a dairy cattle herd. A total of 10 healthy dairy cattle were selected for control group. Analysis of acute phase proteins, hematologic analysis and biochemical analysis was performed in this study. Serum haptoglobin and serum amyloid-A concentrations significantly increased in cattle infected with Anaplasma marginale compared to healthy cattle. All cattle in infected group demonstrated clinical signs of anaplasmosis. Significantly decreased red blood cell count, packed cell volume, and hemoglobin concentration were observed in infected cattle compared to the control group. Serum aspartate aminotransferase, alkaline phosphatase, creatinine and bilirubin concentrations were significantly increased in infected cattle compared with the control group. In conclusion, the changes of biochemical and hematological parameters may be indicate of anemia and tissue damage in cattle with anaplasmosis. Serum haptoglobin and serum amyloid-A concentrations could be usefull in evaluate of acute phase response in cattle infected with Anaplasma marginale.

Keywords:

haptoglobins, Anaplasma marginale, acute phase proteins, alkaline phosphatase, amyloid, anaplasmosis, aspartate aminotransferase, bacterial diseases, bilirubin, blood chemistry, cattle, clinical aspects, cows, creatinine, dairy cattle, erythrocyte count, haematocrit, haematology, haemoglobin,

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