Nuket ÖZKAVRUK ELİYATKIN, Özen Özden YÜKSELEN, Seda KARAOĞLU BAYTEKİN, Yasemin BAŞBINAR, Altay KANDEMİR

İnflamatuvar Fibroid Polipler ve Platelet Türevli Büyüme Faktörü Reseptör Mutasyon Analizi

İnflamatuvar fibroid polip gastrointestinal trakta çok nadir görülen tümörlerden biridir. Klinik olarak çok farklı bulgulara neden olabileceği için tanı zorluğuna neden olur. Ayrıca, histopatolojik olarak da malign bir lezyonu taklit edebilir. İnflamatuvar fibroid poliplerde platelet-derived growth factor receptor α mutasyon varlığı ile ilgili olarak bilgilerimiz artmaktadır. Bu sunumda histopatolojik olarak inflamatuvar fibroid polip morfolojisi bulunan ve platelet-derived growth factor receptor α mutasyonu saptanan üç olgu, bu gibi bir antitenin varlığı ve farkındalığına dikkat çekmek amacıyla literatür bilgileri eşliğinde tartışılmıştır.

Anahtar Kelimeler:

Inflamatuvar fibroid polip, PDGFRA mutasyonu, gastrointestinal trakt, gastrointestinal tract

Inflammatory Fibroid Polyps and Platelet-Derived Growth Factor Receptor Mutation Analysis

Aim: Inflammatory fibroid polyp is one of the most rarely seen tumors in the gastrointestinal tract. It is clinically confusing as it can cause many different findings. On the other hand, it may histopathologically mimic a malignant lesion. Our knowledge about the presence of platelet-derived growth factor receptor α (PDGFRA) mutation in inflammatory fibroid polyps are increasing. Cases: Herein, histopathological and immunohistochemical findings of three different tumors, two localized in the small intestine and one in the stomach, were interpreted as compatible with inflammatory fibroid polyp. PDGFR mutation analysis was performed in both cases and the presence of mutation was detected. Conclusion: The pathogenesis and histogenesis of inflammatory fibroid polyps are uncertain. We obtained results supporting the presence of PFGR mutations in IFPs mimicking both benign and malignant tumors.

Keywords:

Inflammatory fibroid polyp, PDGFRA mutation, gastrointestinal tract,

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