Aydın GÜREL, Mukaddes ÖZCAN, Gülbin AYYILDIZ, Burak KUŞÇU

Changes detected in the organs of quails with experimentally induced hypothyroidism

Çalışmada deneysel hipotiroidizm oluşturulan erkek bıldırcınlarda gelişim durumları ve teslisler başta olmak üzere organlarda meydana gelen değişimler incelenmiştir. Bu amaçla 4 haftalık yaşta 30 tane erkek bıldırcın kullanılmıştır. Bu bıldırcınlar 16'sı deney, 14'ü kontrol olmak üzere iki gruba ayrılmıştır. Deneme grubundaki bıldırcınlara 3 hafta süreyle yem içerisinde %0.2 dozunda propil thiourasil verilirken, kontrol grubundakiler normal bıldırcın yemi ile beslenmişlerdir. Üçüncü hafta her iki gruptaki bıldırcınlardan kan alınarak, serumda T4 düzeyleri tespit edilmiş ve 3. hafta sonunda eter ile ötenazi edilen her iki gruptaki bıldırcınların nekropsileri yapılmıştır. Deney grubundaki, bıldırcınların kalplerinde hafif büyüme oluştuğu, karaciğerlerinin sarımtırak renkte olduğu ve teslislerinin belirgin olarak küçülmüş olduğu saptanmıştır. Tiroidlerin ise normalin 2-3 katı kadar büyüdüğü görülmüştür. Mikroskobik olarak, bazı alanlarda kalp kas tellerinin aralarının açıldığı, hücre sitoplazmalannda granülleşmenin oluştuğu gözlenmiştir. Ayrıca teslislerde tubulusların küçüldüğü saptanmıştır. Tiroidlerde ise follikül epilellerinin aşın hipertrofiye olduğu ve büyüyen hücrelerin follikül lumenini daralttığı görülmüştür. Her iki gruptaki bıldırcınlarda vücut ağırlığındaki artışların islalistiki açıdan önemsiz olduğu tespil edilmiştir. Teslislerdeki ağırlık azalmasının ve kandaki T4 miktarındaki azalmanın P< 0.01 düzeyinde önemli olduğu saplanmışlır.

Deneysel hipotiroidizm oluşturulan bıldırcınlarda organlarda saptanan değişimler

In this study, changes in the organs, especially in the testicles and the growth slales of male quails wilh experimentally induced hypolhyroidism were examined. For this purpose, 30 four-week- old male quails were used, 16 of Ihese were separated as the experimental group and the remaining 14 were used as controls. The quails in the control group were fed with normal quail feed while the quails in the experimenlal group were given 0.2% propyl Ihiouracil by feed for a period of 21 days. Blood samples were collected from bolh groups on the 21st day of the experimenl, and serum T4 levels were determined. Necropsy was performed on the quails of both groups which were euthanised wilh elher al Ihe end of Ihe 21st day. In the experimental group, a slight enlargement of the hearts and a yellowish in color of the livers and an obvious atrophy of the testicles were observed. Also the thyroid glands were found to be swollen 2-3 times larger than their normal size. Microscopically, the spaces between some heart muscle fibres were dilated and granulation occured in the cell cytoplasm. Moreover, tubuli of the testicles were atrophied. In the thyroid it was observed that the follicle epithelia were hypertrophied thus the growing cells caused the obstruction of the follicle luminae. The increase in body weights was determined to be statistically insignificant. The weight loss in the testicles and T4 levels in blood were determined to be significant as P

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