Onkolojide Genetik Gelişmeler ve Hemşirenin Rollerine Etkisi

Uluslararası İnsan Genom Projesi'nin tamamlanmasıyla ivme kazanan genetik alanındaki gelişmeler, sağlık hizmetlerinde yeni fırsatlar sunmakla birlikte, hemşire ve diğer sağlık personeline yeni roller yüklemektedir. Genetik bilimindeki bu ilerleme, özellikle onkoloji alanında çalışan hemşirelerin, genetik gelişmeleri takip ederek klinik uygulamalara temel oluşturacak genetik ve genomik bilgiye sahip olmalarını zorunlu hale getirmiştir. Onkoloji ile genetik biliminin iç içe geçtiği bu noktada, hemşirelerin sağlığı koruma uygulamaları kapsamında atacakları ilk adım kalıtsal kanser gelişimi açısından risk altında olan birey ve aileleri belirlemektir. Bireysel risklere yönelik verilecek eğitim ve danışmalık hizmeti ile bireylerin, hem sağlıklı yaşam biçimi davranışları hem de risk azaltıcı davranış geliştirmelerine olanak sağlanmalıdır. Onkoloji alanında çalışan hemşirelerin uzmanlık gerektiren bu alana ilişkin bilgi ve deneyimin yanı sıra genetik bilgiye sahip olmaları önem taşımaktadır. Kalıtsal kanserler ve bu kanserlerin kalıtım özellikleri hakkında bilgi sahibi olma, kişisel öykü ve aile öyküsü alınması sırasında risk altındaki kişilerin belirlenmesi ve genetik hizmetlerden fayda sağlayacak bireylerin uygun birimlere yönlendirilmesine olanak sağlayacaktır. Bu uygulamalara ek olarak genetik testler, test süreci ve olası sonuçları, risk taşıyan aile üyeleri arasında genetik risk iletişimi ve risk azaltıcı stratejiler konusunda eğitim ve danışmanlık sağlama, onkoloji hemşirelerinin önemli görevlerindendir. Bu derlemede, genetik bilim dalındaki gelişmelerin onkoloji hemşirelerinin rol ve sorumluluklarına etkisi literatür ışığında tartışılacaktır.

Genetic Advances in Oncology and the Effects on Nursing Roles

Developments in genetics, which have gained an exciting momentum with the completion of the International Human Genome Project, are bringing new roles to nurses and other health professionals as well as new opportunities for healthcare delivery. In line with this progress in genetics, it has become compulsory for oncology nurses in particular to gain genetics and genomic knowledge, which provides a basis for clinical practice, by following the developments. At the point of intersection of genetics and oncology, the Ş rst step that nurses should take in the context of healthcare practices is to identify individuals and families at risk for hereditary cancer. Individuals should develop both healthy lifestyle behaviors and risk-reducing behaviors by provided education and counselling regarding personal risk. Oncology nurses should have knowledge and experience in genetics as well as oncology. Having knowledge of hereditary cancers and their inheritance patterns will allow identiŞ cation of individuals at risk while taking personal/family history and directing individuals who may beneŞ t from genetic services to appropriate units. In addition, genetic testing, testing processes and possible results, education and counseling on genetic risk communication and risk reduction strategies to at-risk family members are important tasks of oncology nurses. In this review, the impact of genetic advances on the roles of oncology nurses is discussed in line with the literature.

___

  • 1 . Loescher L, & Merkle C. The interface of genomic technologies and nursing. Journal of Nursing Scholarship. 2005; 37: 111-119. doi: 10.1111/j.1547-5069.2005.00022.x
  • 2 . Caroll J, Rideout A, Wilson B, et al. (2009). Genetic education for primary care providers. Canadian Family Physician. 2009; 55(12):92- 99. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793208/ pdf/0550e92.pdf
  • 3 . Dodson C. Knowledge and attiudes of oncology nurses regarding pharmacogenomic testing. Clinical Journal of Oncology Nursing. 2014; 18(4). doi:10.1188/14.CJON.E64-E70.
  • 4 . Tomatır A, Sorkun H, Demirhan H, Akdağ B. Nurses' professed knowledge of geneics and genetic counseling. Tohuku. J. Exp Med. 2006; 210(4):321-332. https://www.ncbi.nlm.nih.gov/ pubmed/17146198
  • 5 . Burke S, Kirk M. Genetics education in the nursing profession: literature review. J. Adv. Nurs., 2006;54(2): 228-237. doi: 10.1111/j.1365-2648.2006.03805.x
  • 6 . McCreery H. Genetics & genomics: what every oncology nurse needs to know. ONS Connect. 2011;26(2):8-12. https://www.ncbi.nlm.nih. gov/pubmed/21388018
  • 7 . Seven M, Akyüz A, Elbüken B, Skirton H, Öztürk H. Nurses' knowledge and educational needs regarding Genetics. Nurse Education Today. 2015;35: 444-449. doi:10.1016/j.nedt.2014.11.008
  • 8 . Umberger R, Holston E, Hutson S, Pierce M. Nursing genomics, practice implications every nurse should know. Nurs. Clin. N. Am.2013; 48:499-522. doi:10.1016/j.cnur.2013.08.006
  • 9 . Beamer LC, Linder L, Wu B, Eggert J. The impact of genomics on oncology nursing. Nurs Clin N Am. 2013; 48:586- 626. doi: 10.1016/j. cnur.2013.09.007
  • 10 . Anderson G, Metcalfe A. Calling for international colllaborative research in nursing, genetics and genomics: A discussion paper. International Journal of Nursing Studies. 2008; 45(2):323-328. doi:10.1016/j. ijnurstu.2006.08.013
  • 11 . Boucher J, Habin K, Underhill M. Cancer genetics and genomics: essential for oncology nurses. Clinical Journal of Oncology Nursing. 2014;18(3):355-359. doi:10.1188/14.CJON.355-359
  • 12 . Williamson L, LeBlanc, D. A genetic services practice model: advanced practice nurse and genetic counselor team. Newborn Infant Nurs.Rev. 2008; 8(1):30-35. doi:10.1053/j.nainr.2007.12.011
  • 13 . International Society of Nurses in Genetics (ISONG). What is a Genetics Nurse? http://www.isong.org/ISONG_genetic_nurse.php. Erişim Tarihi: 15.07.2016
  • 14 . Debeleç-Bütüner B, Kantarcı G. Mutasyon, Dna hasarı, onarım mekanizmaları ve kanserle ilişkisi. Ankara Ecz. Fak. Derg. 2006; 35(2):149-170. http://dergiler.ankara.edu.tr/dergiler/24/536/6656.pdf
  • 15 . Rieger P. Cancer biology and implications for practice. Clinical Journal of Oncology Nurisng. 2006; 10(4):457-460. doi:10.1188/06. CJON.457-460
  • 16 . Robson M, Storm C, Weitzel J, Wollins D, Offi t K. American society of clinical oncology policy statement update: genetic and genomic testing for cancer susceptibility. Journal of Clinical Oncology. 2010; 25(8):893- 901. doi:10.1200/JCO.2009.27.0660
  • 17 . Demirelli F. Kanserin moleküler temelleri . Güncel Klinik Onkoloji. 2003; 9-15. http://www.ctf.edu.tr/stek/pdfs/37/3701.pdf
  • 18 . Hahn W, Weinberg R. Mechanisms of disease: rules for making human tumor cells. New England Journal of Medicine, 2002; 347:1593-1603. doi:10.1056/NEJMra021902
  • 19 . Oren M, Rotter V. Mutant p53 gain-of-function in cancer. Cold Spring Harbor Perspectives in Biology. 2010; 2(2). doi: 10.1101/cshperspect. a001107.
  • 20 . Croce M. Oncogenes and cancer. The New England Journal of Medicine. 2008; 502-512. doi:10.1056/NEJMra072367
  • 21 . Krug U, Ganser A, Koeffl er P. Tumor supressor genes in normal and malignant hematopoiesis. Oncogene. 2002; 21:3475-3495. doi:10.1038/ sj/onc/1205322
  • 22 . Koff J, Ramachandrian S, Bernal-Mizrachi L. A time to kill: targeting apoptosis in cancer. International Journal of Molecular Sciences. 2015; 16:2942-2955. doi:10.3390/ijms16022942
  • 23 . Cabadak H.. Hücre Siklusu ve Kanser. ADÜ Tp Fakültesi Dergisi. 2008; 9(3):51-61. http://adudspace.adu.edu.tr:8080/xmlui/ handle/11607/2170
  • 24 . Grover S, Syngal S. Risk assessment genetic testing and management of lynch syndrome. Journal of National Compherensive Cancer Network. 2010; 8(1):98-105. https://www.ncbi.nlm.nih.gov/pubmed/20064292
  • 25 . Hampell H, Frankel WL, Martin E, et al. Feasibility of screening for lynch syndrome among patients with colorectal cancer. Journal of Clinical Oncology. 2008; 26(35):5783-5788. doi: 10.1200/ JCO.2008.17.5950
  • 26 . Pelmotaki P. Lynch syndrome genes. Familial Cancer. 2005; 4(3):227- 232. doi:10.1007/s10689-004-7993-0
  • 27 . Vasen H. Clinical description of lynch syndrome (Hereditary Nonpolyposis Colorectal Cancer-HNPCC). Familial Cancer. 2005; 4:219-225. doi:10.1007/s10689-004-3906-5
  • 28 . Edwards Q, Maradiegue A, Siebert D, Jasperson K. Pre- and postassessment of nurse practitioners' knowlegde of hereditary colorectal cancer. Journal of the American Academy of Nurse Practitioners. 2011; 23:361-369.doi:10.1111/j.1745-7599.2011.00625.x
  • 29 . Lu K, Broaddus R. Gynecological cancers in lynch syndrome (HNPCC). Familial Cancer. 2005;4:249-254. doi:10.1007/s10689-005-1838-3
  • 30 . Vasen H, Moslein G, Alonso A, et al. Guidelines for the clinical management of familial adenomatous polyposis.FAP. Gut. 2008; 57(5):704-713. doi:10.1136/gut.2007.136127
  • 31 . Half E, Bercovich D, Rozen P. Familial adenomatous polyposis. Orphanet Journal of Rare Disease, 2009; 4(22):1-23. doi:10.1186/1750-1172-4-22
  • 32 . Edwards Q, Maradiegue A, Siebert D, Humphreys S. Breast cancer risk elements and nurse practitioners' knowledge, use and perceived comfort level of breast cancer risk assessment. Journal of the American Academy o f N u r s e P r a c t i t i o n e r s . 2 0 0 9 ; 2 1 : 2 7 0 - 2 7 7 . doi:10.1111/j.1745-7599.2009.00405.x
  • 33 . Garber J, Offi t K. Hereditary cancer predisposition syndrome. Journal of Clinical Oncology. 2005; 23(2):267-292. doi:10.1200/ JCO.2005.10.042
  • 34 . Lynch H, Silva E, Snyder C, Lynch F. Hereditary breast cancer part I: diagnosing hereditary breast cancer syndromes. The Breast Journal. 2008; 14(1):3-13. doi:10.1111/j.1524-4741.2007.00515.x
  • 35 . Finch A, Beiner M, Lubinsk J, et al. Salpingo-oophorectomy and the risk of ovarian, fallopian tube, and peritoneal cancers in women with a BRCA1 or BRCA2 mutation. JAMA. 2006; 262(2):185-192. doi:10.1001/ jama.296.2.185
  • 36 . Burcher S, Meiser B, Mitchell G, et al. Oncology health professionals' attiudes toward treatment-focused genetic testing for women newly diagnosed with breast cancer. Personalized Medicine. 2013; 10(5):431- 440. doi:10.2217/pme.13.45
  • 37 . Bordeleau L, Panchal S, Goodwin P. Prognosis of BRCA-associated breast cancer:a summary of evidence. Breast Cancer Res. Treat. 2010; 119(1):13-24. doi:10.1007/s10549-009-0566-z
  • 38 . Pierce L, Phillips K, Griffi th K, et al. Local therapy in BRCA1 and BRCA2 mutation carriers with operable breast cancer: Comparison of breast conservation and mastectomy. Breast Cancer Res. Treat. 2010;121(2):389-398. doi:10.1007/s10549-010-0894-z
  • 39 . George R, Kovak K, Cox S. Alingning policy to promote cascade genetic screening for prevention and early diagnosis of heritable disease. J. Genet. Councel. 2015; 24(3):388-99. doi:10.1007/s10897-014-9805-5
  • 40 . Ilgın Ruhi H. Meme kanserinde farmakogenetik. Türkiye Klinikleri J Med Sci. 2010; 30(1):16-21.http://www.turkiyeklinikleri.com/article/ tr-meme-kanserinde-farmakogenetik-58153.html
  • 41 . Lea D, Skirton H, Read C, Williams J. Implications for educating the next generation of nurses on genetics and genomics in the 21st century. J.Nurs. Scholarsh. 2011; 43(1):3-13. doi:10.1111/j.1547-5069.2010.01373.x
  • 42 . Blackhall FH, Howell S, Newman B. Pharmacogenetics in the management of breast cancer prospects for individualised treatment. Fam Cancer. 2006; 5(2):151-157. doi:10.1007/s10689-005-3241-5
  • 43 . Floria-Santos M, Santos E, Nacimento L, et al. Oncology nursing practice from the perspective of genetics and genomics. Refl ection. 2013; 22(2):526-533. http://www.scielo.br/pdf/tce/v22n2/en_ v22n2a31.pdf
  • 44 . Oncology Nursing Society (ONS). Oncology nursing: the application of cancer genetics and genomics throughout the oncology care continuum https://www.ons.org/advocacy-policy/positions/education/ genetics (Erişim Tarihi: 10.07.2016).
  • 45 . Association of Genetic Nurses and Counsellors United Kingdom (AGNC). The future role of genetic counsellors in genomic healthcare: a statement by the association of genetic nurses and counsellors. (Erişim Tarihi: 10.07.2016) http://www.agnc.org.uk/media/925792/agnc_ vision_statement_fi nal.pdf
  • 46 . Jenkins J. Essential genetic and genomic nursing competiencs for the oncology nurse. Semin Oncol Nurs. 2001; 27(1):64-71. doi:10.1016/j. soncn.2010.11.008
  • 47 . Hamples H, Bennett R, Buchanan A, et, al. A practice guideline from the american college of medical genetics and genomics and the national society of genetic counselors: referral indications for cancer predisposition assessment. Genetics in Medicine. 2015; 17(1):70-87. doi:10.1038/gim.2014.147
  • 48 . Bancroft E. Genetic testing for cancer predisposition and implications for nursing practice: narrative review. J Adv Nurs. 2010; 66(4):710-737. doi:10.1111/j.1365-2648.2010.05286.x
  • 49 . Santos E, Edwards Q, Florias-Santos M, Rogatto S, Achatz M, McDonald D. Integration of genomics in cancer care. Journal of Nursing Scholarship. 2013; 45:43-51. doi:10.1111/j.1547-5069.2012.01465.x
  • 50 . Calzone K, Jenkins J, Nicol N, Skirton H, Feero W, Green E. Relevance of genomics to healthcare and nursing practice. Journal of Nursing Scholarship. 2013; 45:1-2. doi:10.1111/j.1547-5069.2012.01464.x
  • 51 . Calzone K, Jenkins J, Culp S, Bonham V, Badzek L. National nursing workforce survey of nursing attiudes, knowledge and practise in genomics. Per. Med. 2013; 10(7). doi:10.2217/pme.13.64