Koyunlarda artan dozlarda uygulanan meloksikamın hematolojik, biyokimyasal ve hemostatik kan parametrelerine etkilerinin değerlendirilmesi

Amaç: Çalışmanın amacı, koyunlara damar içi artan dozlarda (0,5, 1 ve 2 mg/kg) meloksikam uygulamasının hematolojik, biyokimyasal ve koagülasyon parametrelerine etkisinin belirlenmesiydi. Gereç ve Yöntem: Klinik olarak sağlıklı koyunlar Grup 1 (n=6), Grup 2 (n=6) ve Grup 3 (n=6) olmak üzere rastgele grublara ayrıldı. Meloksikam grup 1’e 0,5 mg/kg, Grup 2’ye 1 mg/kg ve Grup 3’e 2 mg/kg damar içi yolla tek doz uygulandı. Meloksikamın artan tek dozlarda uygulamasının hematolojik, biyokimyasal ve pıhtılaşma faktörlerine etkisini belirlemek için 0., 24., ve 72. saatlerde kan örnekleri toplandı. Ayrıca hemogram (RBC, MCV, MCH, MCHC, HCT, WBC, HGB, RDW, MPV, PDW, PCT, PLT) ve biyokimyasal parametreler (AST, ALT, ALP, GGT, TP, UREA, CREA, CHOL, TRIG, ALB) ile koagülasyon parametrelerinin (PT, APTT, INR, FIB) seviyeleri belirlendi. Bulgular: Gruplarda; UREA dışındaki biyokimyasal ve RBC, HCT, MCV, MCHC, MPV paremetrelerindeki farklar istatisksel olarak anlamlıydı (p

Evaluation of the effects of increasing doses of meloxicam on hematological, biochemical and hemostatic blood parameters in sheep

Aim: The aim of the study was to determine the effect of intravenous administration of meloxicam at increasing doses (0.5, 1 and 2 mg/kg) on hematological, biochemical and coagulation parameters in sheep. Materials and Methods: Clinically healthy sheep were randomly divided into groups as Group 1 (n:6), Group 2 (n:6) and Group 3 (n:6). Meloxicam was administered intravenously as a single dose of 0,5 mg/kg in Group 1, 1 mg/kg in Group 2 and 2 mg/kg in Group 3. To determine the effect of increasing single doses of meloxicam on hematological, biochemical and coagulation factors, blood samples were collected at 0, 24, and 72 hours. In addition, hemogram (RBC, MCV, MCH, MCHC, HCT, WBC, HGB, RDW, MPV, PDW, PCT, PLT) and biochemical parameters (AST, ALT, ALP, GGT, TP, UREA, CREA, CHOL, TRIG, ALB) ) and the levels of coagulation parameters (PT, APTT, INR, FIB) were determined. Results: In groups; Differences in biochemical parameters other than UREA and parameters of RBC, HCT, MCV, MCHC, MPV were statistically significant (p

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Yazar Katkıları Fikir/Kavram: Fulya Altınok Yipel Hüseyin Güngör
Tasarım: Fulya Altınok Yipel Hüseyin Güngör
Denetleme/Danışmanlık: Fulya Altınok Yipel Hüseyin Güngör
Veri Toplama ve/veya İşleme: Fulya Altınok Yipel Hüseyin Güngör
Analiz ve/veya Yorum: Fulya Altınok Yipel Hüseyin Güngör
Kaynak Taraması: Fulya Altınok Yipel Hüseyin Güngör
Makalenin Yazımı: Fulya Altınok Yipel Hüseyin Güngör
Eleştirel İnceleme: Fulya Altınok Yipel Hüseyin Güngör
Bu çalışma Hatay Mustafa Kemal Üniversitesi Hayvan deneyleri Yerel Etik Kurulu’nun onayı ile gerçekleştirilmiştir (2021/01-01).