Hasbi Sait SALTIK, Kamil ATLI, Mehmet KALE

Ağır akut solunum yolu yetersizliği sendromu coronavirus 2 (SARS-CoV-2): patogenez ve virus-konak etkileşimleri

Coronaviruslar son yirmi yıl içerisinde üç farklı dönemde salgına neden olarak küresel bir tehdit oluşturmuştur. İlk olarak 2003’te Ağır Akut Solunum Yolu Yetersizliği Sendromu (SARS-CoV) ortaya çıktı. Sonra 2012’de Ortadoğu Ağır Akut Solunum Yolu Yetersizliği Sendromu (MERS-CoV) tespit edildi. 2019 yılının sonlarında ise Ağır Akut Solunum Yolu Yetersizliği Sendromu Coronavirus 2 (SARS-CoV-2)’nin izole edildiği bildirildi. SARS-CoV ve MERS-CoV’a kıyasla çok daha şiddetli ve yaygın bir enfeksiyona neden olan SARS-CoV-2, aşı geliştirilinceye kadar küresel bir tehdit olmaya devam edecektir. SARS-CoV-2 salgınının hala devam etmesi nedeniyle, virus-konak etkileşimleri ve hastalığın patogenezi ile ilgili birçok konunun daha detaylı ele alınması gerekmektedir

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): pathogenesis and virus-host interactions

Coronaviruses have posed a global threat in three differentperiods over the past two decades. Severe Acute Respiratory Failure Syndrome (SARS-CoV) was first revealed in 2003.Then, in 2012, Middle East Severe Acute Respiratory FailureSyndrome (MERS-CoV) was detected. In late 2019, it was reported that Coronavirus 2 (SARS-Cov-2) was isolated fromSevere Acute Respiratory Failure Syndrome. SARS-Cov-2,which causes a much more severe and common infectioncompared to SARS-Cov and MERS-Cov, remains a globalthreat until the vaccine is developed. Owing to the ongoingoutbreak of SARS-Cov-2, many facts regarding virus-hostinteractions and pathogenesis of disease, still needed to beaddressed in more detail.

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