Obezlerde Ortalama Platelet Hacmi (MPV), vücut kitle indeksi ile koreledir

Amaç: Obezite, tüm dünyada giderek yaygınlaşan, diabetes mellitus, hipertansiyon ve koroner arter hastalığı gibi önemli kronik hastalıklara yol açan bir sağlık problemidir. Trombositler, hemostaz dışında inflamasyon ve endotel aktivasyonu gibi bir çok önemli yolakta rol oynayan kan bileşenlerinden biridir. Hacimleri artıkça metabolik olarak daha aktif olurlar. Yapılan bir çok çalışmada MPV artışının; akut koroner sendrom, stent trombozu ve serbrovasküler olay seyrinde olumsuz etkilerinin olduğu görülmüştür. Bu çalışmada obezite tanım ve sınıflandırmasında kullanılan vücut kitle İNDEKSİ (VKİ) ve ortalama trombosit hacmi (MPV) arasında korelasyonun olup olmadığının değerlendirilmesi amaçlanmıştır. Yöntem: Obezite nedeni ile dahiliye polikliniğine başvuran ve hipertansiyon diabetes mellitus ve hiperlipidemi saptanmayan 78 hasta çalışmaya dahil edilmiştir. Hastaların bazal demografik özellikleri kayıt edildikten sonra olası kardiyak patolojileri dışlamak için transtorasik ekokardiyografik inceleme yapılmıştır. Rutin biyokimya ve kan parametleri için örnekler alınıp incelenmiştir. Bulgular: Hastaların ortalama yaşları 45.06 (±10.69) yıl olup, ortalama VKİ 43.4 kg/m2 (±5.3) olarak tespit edilmiştir. Transtorasik ekokardiyografik incelemeleri normal sınırlarda tespit edilmiştir. Ortalama trombosit hacimleri 8.57 fL(±1.22) olup VKİ ile MPV arasında pozitif korelasyon saptanmıştır (p:0.004, r:0.319). Diğer parametler ile anlamlı korelasyon tespit edilmememiştir. Sonuç: Vücut kitle İNDEKSİ artışı MPV değerindeki artış ile koroledir. Obezite hastalarında VKİ artış ile birlkte görülen kronik hastalıkların etyopatogenizde MPV artışı rol oynayabilir.

Mean Platelet Volume (MPV) is correlated with body mass index

Objective: Obesity is a common health problem all over the world, leading to significant chronic diseases such asdiabetes mellitus, hypertension, and coronary artery disease. Platelets are one of the blood components that play a rolein a number of important pathways such as inflammation and endothelial activation other than hemostasis. Theybecome more metabolically active as their volume increases. In many studies the increase in MPV has negative effectson the acute coronary syndrome, stent thrombosis, and cerebrovascular events. In this study, it was aimed to evaluatewhether there is a correlation between body mass index (BMI) used in the definition and classification of obesity andmean platelet volume (MPV).Method: Seventy-two patients who presented to the internal medicine outpatient clinic due to obesity and had nohypertension, diabetes mellitus and hyperlipidemia were included in the study. After the basal demographiccharacteristics of the patients were recorded, the transthoracic echocardiographic examination was performed toexclude possible cardiac pathologies. Examples of routine biochemistry and blood parameters were obtained andanalyzedResults: The mean age of the patients was 45.06 (± 10.69) years, and the mean BMI was determined as 43.4 kg / m2(± 5.3). Transthoracic echocardiographic examinations were found within normal limits. The mean platelet volume was8.57 fL (± 1.22), and there was a positive correlation between BMI and MPV (p: 0.004, r: 0.319). No significantcorrelation was found with other parameters.Conclusions: Increase in body mass index is correlated with an increase in MPV values. MPV increase may play a rolein the etiopathogenesis of chronic diseases associated with BMI increase in obesity patients.

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