Tip 2 diabetes mellitusta komplikasyonların öngörülmesinde nötrofil-lenfosit oranının yararlılığı
Amaç: İnflamatuar bir hastalık olarak tip 2 diabetes mellitus (T2DM) kavramı son zamanlarda ortaya çıkmış ve mevcut kanıtlar ile doğrulanmış gibi görünmektedir. Çalışmanın amacı, T2DM hastalarında nötrofillenfosit oranının (NLR) rolünü, C-reaktif protein (CRP), eritrosit sedimantasyon hızı (ESR) ve fibrinojen gibi iyi bilinen diğer inflamatuar belirteçlerle karşılaştırmayı araştırmaktır. Ayrıca T2DM'deki komplikasyonların belirlenmesinde NLR’nin klinik kullanımındaki yararlılığı da araştırıldı. Yöntem: Çalışma, Nisan-Ekim 2017 tarihleri arasında mevcut hastaların oluşturduğu altı gruptan oluşuyordu; Komplikasyonsuz diyabetik grup (DM) (n=35), koroner arter hastalığı (KAH) grup (n=35), KAH+DM grup (n=35), DM+nefropati grup (n=30), DM+nöropati grup (n=30), DM+retinopati grup (n=30) ve sağlıklı kontrol grup (n=40). Bulgular: Ortalama NLR değerleri tüm hastalarda kontrollere göre anlamlı olarak daha yüksek bulundu. KAH+DM grubu, gruplar arasında en yüksek NLR değerlerine (4.173.85) sahiptir. DM+nefropati, DM+nöropati ve DM+retinopati grupları arasında anlamlı fark yoktur. KAH+DM grubunda ortalama NLR değerleri DM+nefropati, DM+nöropati ve DM+retinopati grubundan anlamlı olarak daha yüksek bulundu (her bir karşılaştırma için p
Usefulness of the neutrophil-to-lymphocyte ratio to prediction of complications in type 2 diabetes mellitus
Objective: Increasing evidences show that the concept of type 2 diabetes mellitus (T2DM) as aninflammatory disease has emerged. The aim of the present study was to investigate the role of neutrophil-tolymphocyteratio (NLR) in T2DM patients comparing with the other well-known inflammatory markers asC-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen. It also investigatesusefulness of the NLR to prediction of complications in T2DM.Method: This study consisted of six patients groups in İstanbul Medicine Hospital between April-October,2017: It enrolled the laboratory results of 195 subjects of which diabetic group (DM) (n=35), coronary arterydisease (CAD) group (n=35), CAD+DM group (n=35), DM+nephropathy (n=30), DM+neuropathy (n=30),DM+retinopathy (n=30), and 40 healthy controls.Results: The mean NLR values were significantly higher in all patients than controls. CAD+DM group hasthe highest NLR values (4.173.85) among the groups. There was no significant difference between theDM+nephropathy, DM+neuropathy, and DM+retinopathy. The mean NLR values were significantly higherin CAD+ DM group than DM+nephropathy, DM+neuropathy, and DM+retinopathy (for each comparisonp
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