Rosacea hastalığı ve Demodex spp ilişkisi; Retrospektif çalışma
Amaç: Bu çalışmanın amacırosacea tanısı konmuş hastalardaDemodex spp. yaygınlığını belirlemektir. Yöntem: Çalışmamızda Sivas Numune Hastanesi Dermatoloji polikliniğine 01.01.2018 ve 25.09.2018 tarihleri arasında gelen ve rosacea tanısı konmuş hasta grubuDemodexspp yaygınlığı açısından incelendi. Çalışmada 338 hastadan standart deri yüzey biyopsisi (SDYB) yöntemi ile örnekler alındı. Bulgular: Üçyüz otuz sekiz rosacea hastasının 166 (%49,1)’sındaDemodex spp. pozitif bulundu. Bu durum cinsiyete göre değerlendirildiğinde 59 erkek hastada Demodex spp. pozitifliği 17 (%28,8) iken 279 kadın hastanın136 (%48,7) idi ve bu fark istatistiksel olarak anlamlıydı (Tablo 1). Cinsiyete göre Demodex spp. pozitifliği istatistiksel olarak önemli bulundu (p
Rosacea disease and Demodex spp. relationship; Retrospective study
Rosacea.Method: In our study, the patient group who visited Sivas Numune Hospital Dermatology Outpatient Clinic betweenJanuary 01, 2018 and September 25, 2018, and was diagnosed with Rosacea was observed with respect toDemodexspp.Samples were taken from 338 patients with the procedure of Standardized Skin Surface Biopsy (SSSB).Results: The presence of Demodex spp. was found to be positive in 166 (49.1 percent) of 338 rosacea patients. Whenthe patients are evaluated based on gender, 17 (28.9 percent) of 59 male patients and 136 (48.7 percent) of 279 femalepatients were detected to have Demodex spp.and this difference was statistically significant (Table 1). Positivity ofDemodex spp. based on gender was deemed statistically significant (p
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- Jarmuda S, O’Reilly N, Żaba R,
Jakubowicz O, Szkaradkiewicz A,
Kavanagh K. Potential role of Demodex
mites and bacteria in the induction of
rosacea. J Med Microbiol. 2012;61:1504-
1510.
- 2. Crawford GH, Pelle MT, James WD.
Rosacea: I. Etiology, pathogenesis, and subtype classification. J Am Acad
Dermatol. 2004;51:327-341.
- Del JR. Update on rosacea pathogenesis
and correlation with medical therapeutic
agents. Cutis. 2006;78:97-100.
- Erbagci Z, Ozgoztasi O. The significance
of Demodex folliculorum density in
rosacea. Int J Dermatol. 1998;37:421-
425.
- Aycan OM, Otlu GH, Karaman U, Daldal
N, Atambay M. Frequency of
Demodicosis in Various Patient and Age
Groups. Turkish J Parasitol.
2007;31:115-118.
- Balcioglu I, Yolasigmaz A. Diagnosis of
arthropods of medical importance.
Korkmaz M, Ok UZ, editurs. Laboratory
in Parasitology. İzmir: Meta
Issue2011:132.
- Forton F. Elucidating the role of
Demodex folliculorum in the
pathogenesis of rosacea: exciting first
steps. Br J Dermatol. 2018;179:252-253.
- Unal E, Akcinar UG, Arduc A.
Hidradenitis suppurativa, metabolic
syndrome, and Demodex spp. infestation.
Turkish J Parasitol. 2018;42:171-174.
- Bilal N, Kirisci O, Ozkaya E. Demodex
Species Infestation in Patients with Ear
Itching and Its Relationship to Itch
Severity. Turkish J Parasitol. 2017;41:87.
- Saygi G. Parasitic diseases. Sivas: Es
Form Ofset. 2009:269-271.
- Yolasigmaz A, Budak S. Demodicosis.
Özcel MA, Özbel Y, Ak M, editors. Ozcel's
Medical Parasitic Diseases. İzmir: Meta
Basım2007.
- Ozcelik S, Sumer Z, Degerli S, et al. The
incidence of Demodex folliculorum in
patients with chronic kidney deficiency
Turkish J Parasitol. 2007;31:66-68.
- Yucel A, Yilmaz M. Investigation of the
prevalance of Demodex folliculorum and
Demodex brevis in rosacea patients.
Turkish J Parasitol. 2013;37:195.
- Aydogan K, Baskan EB, Tunali Ş. A
comparison of efficacy of .75%
metronidazole geland 5% permethrin
cream in the treatment of rosacea. Turkiye
Klinikleri J Dermatol. 2001;11:94-101.