Klinik Uygulamalarda Düşük Glisemik ve/veya Besin İnsülin İndeksli Beslenme Yaklaşımları

Obezite, diyabet ve kalp-damar hastalıkları gibi yaşam tarzıyla ilişkili kronik hastalıkların postprandiyal glisemi ve insülinemi ile ilişkisi bilinmektedir. Bu nedenle, araştırmacılar postprandiyal glisemi ve insülinemiyi kontrol altına alabilecek çeşitli yöntem arayışlarına girmiş ve yeni kavramlar geliştirmişlerdir. Bu kavramlardan en önemlileri 1981 yılında ilk kez tanımlanan glisemik indeks iken, diğeri 1997 yılında ortaya atılan besin insülin indeksidir. Glisemik indeks (Gİ), karbonhidrat içeren besinlerin kan glukozunu yükseltme potansiyelini göstermektedir. Besin insülin indeksi (İİ) ise sadece karbonhidrat içeren besinlerin değil, tüketilen tüm besinlerin insülin düzeyi üzerine etkilerini değerlendirmekte ve böylece protein ve yağların olası etkilerini de göz önünde bulundurmaktadır. Günlük diyette daha çok düşük Gİ’li ve/veya İİ’li besinler tercih edilerek uzun dönemde yaşam tarzı ile ilişkili kronik hastalıklara yakalanma riski azaltılabilir. Aynı zamanda, yapılan çalışmalarda düşük Gİ’li ve/veya İİ’li öğünlerin kısa dönem olumlu etkileri olabileceği de gösterilmiştir. Düşük Gİ’li ve/veya İİ’li öğün tüketimi sonrası, yüksek Gİ’li ve/veya İİ’li öğüne göre postprandiyal hiperglisemi ve hiperinsülinemi oluşumunun önlenebileceği ve açlık hissinin azaltılıp, doygunluğu arttırarak iştahın kontrol altına alınabileceği önerilmektedir. Bu nedenle, düşük Gİ’li ve/veya İİ’li diyetlerin obezite ve diyabet tedavisinde yararlı olabileceğine işaret edilmektedir. Günümüzde, sağlıklı bir yaşam için fiziksel aktivite ve yeterli-dengeli beslenmenin yanısıra tüketilen besinlerin kalitesi de önem kazanmaktadır. Besinin Gİ ve İİ değeri besin kalitesini değerlendirmek amacıyla kullanılabilecek kriterler arasında yer almaktadır.

Low Glycemic Index and/or Food Insulin Index Approaches in Clinical Practice

Lifestyle-related chronic diseases such as obesity, diabetes and cardiovascular diseases are known to be associated with postprandial glycemia and insulinemia. For this reason, researchers have sought out various methods that can control postprandial glycemia and insulinemia and have developed new concepts. The most important of these concepts is the glycemic index, which was first described in 1981, and the other is the food insulin index, introduced in 1997. The glycemic index (GI) shows the blood glucose raising potential of carbohydrate-containing foods. The food insulin index (FII) assesses not only the carbohydrate-containing foods but also the effects of all consumed foods on the insulin level, thus taking into account possible effects of proteins and fats. The risk of chronic life-style related diseases in the long term can be reduced by preferring foods with lower GI and/or FII in the daily diet. It has also been shown in the conducted studies that low GI and/ or FII meals may have short-term positive effects. It is suggested that the postprandial hyperglycemia and hyperinsulinemia can be prevented and the appetite can be controlled by reducing hunger feeling, increasing satiety after low GI and/or FII meal consumption than after high GI and/or FII meal. In this respect, it is pointed out that low GI and/or FII diets may be useful in the treatment of obesity and diabetes. Recently, the quality of the consumed food as well as physical activity and adequate-balanced nutrition become important for a healthy life. The GI and II indices of food are also among the criteria that can be used to assess its quality.

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  • Bao J, Atkinson F, PetoczP,Willett WC, Brand-Miller JC. Prediction of postprandial glycemia and insulinemia in lean, young, healthy adults: Glycemic load compared with carbohydrate content alone. Am J Clin Nutr 2011;93:984-996.
  • ÖzelHG.Glisemikindeksveyük:Gerçeklerveçelişkiler (Eds:TayfurM,AyhanNY).BeslenmeveDiyetetikGüncel Konular - II. 1. Baskı. Hatiboğlu Yayınevi, Ankara, 2015, s.109-136.
  • KongKL,HendrichS.Glycemicindex,insulinemicindex, and satiety index of kefir. J Am Coll Nutr 2012;31:280- 287.
  • JointFAO/WHOExpert Consultation on Carbohydrates in Human Nutrition (1998: Rome, Italy) &WorldHealth Organization(1998).Carbohydratesinhumannutrition: Report of a jointFAO/WHOexpert consultation, Rome, 14-18 April 1997. Rome :FAO.
  • Nimptsch K, Brand-Miller JC, Franz M, Sampson L, Willett WC, Giovannucci E. Dietary insulin index and insulin load in relation to biomarkers of glycemic control, plasma lipids, and inflammation markers. Am J Clin Nutr2011;94:182-190.
  • HoltSH,MillerJC,PetoczP.Aninsulinindexoffoods:the insulin demand generated by 1000-kJ portions of common foods. Am J Clin Nutr1997;66:1264-1276.
  • Bao J, de JongV,Atkinson F, PetoczP,Brand-Miller JC.Foodinsulin index: Physiologic basis for predicting insulin demand evoked by composite meals. Am J Clin Nutr2009;90:986-992.
  • JakubowiczD,WainsteinJ,AhrénB,Bar-DayanY,Landau Z, Rabinovitz HR, et al. High-energy breakfast with low- energy dinner decreases overall daily hyperglycaemia in type 2 diabetic patients: A randomised clinical trial. Diabetologia2015;58:912-919.
  • KongAP,Chan RS, Nelson EA, Chan JC. Role of low- glycemic index diet in management of childhoodobesity.Obes Rev 2011;12:492-498.
  • RouhaniMH,KelishadiR,HashemipourM,Esmaillzadeh A, Azadbakht L. Glycemic index, glycemic load and childhoodobesity:Asystematicreview.AdvBiomedRes 2014;3:47-54.
  • Dickinson S, HancockDP,PetoczP,Ceriello A, Brand- Miller J. High-glycemic index carbohydrate increases nuclear factor-kappaB activation in mononuclear cells of young, lean healthy subjects. Am J Clin Nutr 2008;87:1188-1193.
  • Nilsson AC, Ostman EM, Holst JJ, Bjorck IM. Including indigestible carbohydrates in the evening meal of healthy subjects improves glucose tolerance, lowers inflammatory markers, and increases satiety after a subsequentstandardizedbreakfast.JNutr2008;138:732- 739.
  • Pawlak DB, Kushner JA, Ludwig DS. Effects of dietary glycaemic index on adiposity, glucose homoeostasis, and plasma lipids in animals. Lancet2004;364:778-785.
  • Isken F, Klaus S, Petzke KJ, Loddenkemper C, Pfeiffer AF,WeickertMO. Impairment of fat oxidation under high- vs. low-glycemic index diet occurs before the development of an obese phenotype. Am J Physiol Endocrinol Metab2010;298:E287-295.
  • Joslowski G, Goletzke J, Cheng G, Günther AL, Bao J, Brand-Miller JC, et al. Prospective associations of dietary insulin demand, glycemic index, and glycemic load during puberty with body composition in young adulthood. Int J Obes (Lond)2012;36:1463-1471.
  • ChaputJP,Tremblay A, Rimm EB, Bouchard C, Ludwig DS. A novel interaction between dietary composition and insulin secretion: Effects on weight gain in the Quebec FamilyStudy.Am J Clin Nutr2008;87:303-309.
  • Kaaks R, Lukanova A. Energy balance and cancer: the role of insulin and insulin-like growth factor-I. Proc Nutr Soc2001;60:91-106.
  • Aston LM, Stokes CS, Jebb SA. No effect of a diet with a reduced glycaemic index onsatiety,energy intake and bodyweightinoverweightandobesewomen.IntJObes (Lond) 2008;32:160-165.
  • Krog-Mikkelsen I, Sloth B, Dimitrov D, Tetens I, Björck I, Flint A, et al. A low glycemic index diet does not affect postprandial energy metabolism but decreases postprandial insulinemia and increases fullness ratings in healthy women. J Nutr2011;141:1679-1684.
  • Zakrzewski JK, Stevenson EJ, Tolfrey K. Effect of breakfastglycemicindexonmetabolicresponsesduring rest and exercise in overweight and non-overweight adolescent girls. Eur J Clin Nutr2012;66:436-442.
  • Çelik H. Eksojen Obez Adolesanların Düşük ve Yüksek Glisemik İndeksli Kahvaltıya Yanıtının Serum Glikoz, İnsülin,C-PeptidveLipidDüzeyleriileDeğerlendirilmesi (Uzmanlık Tezi). Edirne: Trakya Üniversitesi;2007.
  • Reynolds RC, Stockmann KS, Atkinson FS, Denyer GS, Brand-Miller JC. Effect of the glycemic index of carbohydrates on day-long (10 h) profiles of plasma glucose, insulin, cholecystokinin and ghrelin. Eur J Clin Nutr2009;63:872-878.
  • Stevenson EJ, Astbury NM, Simpson EJ, Taylor MA, Macdonald IA.Fatoxidation during exercise and satiety during recovery are increased following a low- glycemic index breakfast in sedentary women. J Nutr 2009;139:890-897.
  • Morgan LM, ShiJW,Hampton SM, Frost G. Effect of meal timing and glycaemic index on glucose control and insulin secretion in healthy volunteers. Br J Nutr 2012;108:1286-1291.
  • Burton-Freeman BM, Keim NL. Glycemic index, cholecystokinin, satiety and disinhibition: Is there an unappreciated paradox for overweight women? Int J Obes (Lond)2008;32:1647-1654.
  • Liu AG, Most MM, Brashear MM, Johnson WD, CefaluWT,Greenway FL. Reducing the glycemic index or carbohydrate content of mixed meals reduces postprandial glycemia and insulinemia over the entire day but does not affectsatiety.Diabetes Care 2012;35:1633-1637.
  • Lennerz BS, Alsop DC, Holsen LM, Stern E, Rojas R, Ebbeling CB, et al. Effects of dietary glycemic index on brainregionsrelatedtorewardandcravinginmen.Am J Clin Nutr2013;98:641-647.
  • SolomonTP,Haus JM, Kelly KR, Cook MD, Filion J, Rocco M, et al. A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia,andglucose-dependentinsulinotropic polypeptide responses in obese, prediabetic humans. Am J Clin Nutr2010;92:1359-1368.
  • Milton JE, Sananthanan CS, Patterson M, GhateiMA, BloomSR,FrostGS.Glucagon-likepeptide-1(7-36)amide responsetolowversushighglycaemicindexpreloadsin overweightsubjectswithandwithouttypeIIdiabetes mellitus. Eur J Clin Nutr 2007;61:1364-1372.
  • Brownley KA, Heymen S, Hinderliter AL, Galanko J, MacintoshB.Low-glycemicloaddecreasespostprandial insulin and glucose and increases postprandial ghrelin in white but not black women. J Nutr 2012;142:1240- 1245.
  • Runchey SS, Pollak MN, Valsta LM, Coronado GD, SchwarzY,Breymeyer KL, et al. Glycemic load effect on fasting and post-prandial serum glucose, insulin, IGF-1 and IGFBP-3 in a randomized, controlled feedingstudy.Eur J Clin Nutr2012;66:1146-1152.
  • Runchey SS, Valsta LM, SchwarzY,WangC, Song X, LampeJW,et al. Effect of low- and high-glycemic load on circulating incretins in a randomized clinical trial. Metabolism2013;62:188-195.
  • BallSD,KellerKR,Moyer-MileurLJ,DingYW,Donaldson D, Jackson WD. Prolongation of satiety after low versus moderately high glycemic index meals in obese adolescents. Pediatrics2003;111:488-494.
  • Cooper SB, Bandelow S, Nute ML, Morris JG, Nevill ME. Breakfast glycaemic index and exercise: Combined effects on adolescents' cognition. Physiol Behav 2015;139:104-111.
  • Ludwig DS, Majzoub JA, Al-Zahrani A, Dallal GE, Blanco I, Roberts SB. High glycemic index foods, overeating, andobesity.Pediatrics1999;103:E26.
  • Mirza NM, Klein CJ, Palmer MG, McCarter R, He J, Ebbeling CB, et al. Effects of high and low glycemic load meals on energy intake, satiety and hunger in obese Hispanic-American youth. Int J Pediatr Obes 2011;6:e523-31.
  • OrduTY.Beden Kütle İndeksleri FarklıYetişkinBireylerde Öğünün Glisemik Yükünün Kan Şekeri Üzerindeki Etkisi (Yüksek Lisans Tezi). Ankara: Hacettepe Üniversitesi;2011.
  • Bell KJ, Bao J, PetoczP,Colagiuri S, Brand-Miller JC. Validation of the food insulin index in lean, young, healthy individuals, and type 2 diabetes in the context of mixed meals: An acute randomized crossover trial. Am J Clin Nutr2015;102:801-806.
  • Augustin LS, KendallCW,Jenkins DJ, Willett WC,Astrup A, BarclayAW,et al. Glycemic index, glycemic load and glycemic response: An International Scientific ConsensusSummitfromtheInternationalCarbohydrate Quality Consortium (ICQC). Nutr Metab Cardiovasc Dis 2015;25:795-815.
  • McMillan-Price J, Brand-Miller J. Low-glycaemic index diets and body weight regulation. Int J Obes 2006;30:S40-S46.
  • Joslowski G, Halim J, Goletzke J, Gow M, Ho M, Louie JC, etal.Dietaryglycemicload,insulinload,andweightloss in obese, insulin resistant adolescents: RESISTstudy. Clin Nutr 2015;34:89-94.
  • Juanola-Falgarona M, Salas-Salvadó J, Ibarrola-Jurado N, Rabassa-Soler A, Díaz-López A, Guasch-Ferré M, et al. Effect of the glycemic index of the diet on weight loss, modulation ofsatiety,inflammation, and other metabolic risk factors: A randomized controlled trial. Am J Clin Nutr2014;100:27-35.
  • Batista SMM, Moreira EAM, Fiates GMR, de Assis MAA, TeixeiraE.Effectoflowglycaemicindexdietsonsatiety.BrFoodJ2014;116:1233-1246.
  • ChangKT,LampeJW,SchwarzY,Breymeyer KL, Noar KA, Song X, et al. Low glycemic load experimental diet moresatiatingthanhighglycemicloaddiet.NutrCancer 2012;64:666-673.
  • MunstersMJ,GeraedtsMC,SarisWH.Effectsofdifferent protein and glycemic index diets on metabolic profiles and substrate partitioning in lean healthy males. Appl Physiol Nutr Metab2013;38:1107-1114.
  • ProbstA,HumpelerS,HeinzlH,BlascheG,Ekmekcioglu C. Short-term effect of macronutrient composition and glycemic index of a yoghurt breakfast on satiety and mood in healthy young men. Forsch Komplementmed 2012;19:247-251.
  • RosenLA,OstmanEM,BjorckIM.Postprandialglycemia, insulinemia, and satiety responses in healthy subjects after whole grain rye bread made from different rye varieties. J AgriclFoodChem2011;59:12149-12154.
  • Simmons AL, Miller CK, Clinton SK,VodovotzY.A comparison ofsatiety,glycemic index, and insulinemic indexofwheat-derivedsoftpretzelswithorwithoutsoy.FoodFunct2011;2:678-683.
  • Gonzalez-Anton C, Rico MC, Sanchez-Rodriguez E, Ruiz- LopezMD,GilA,MesaMD.Glycemicresponses,appetite ratingsandgastrointestinalhormoneresponsesofmost common breads consumed in Spain: A randomized control trial in healthy humans. Nutrients 2015;7:4033- 4053. Brouns F, Bjorck I, Frayn KN, Gibbs AL, LangV,Slama G, et al. Glycaemic index methodology. Nutr Res Rev 2005;18:145-171.