Canan BALCI, H. Selim KARABEKİR, İLHAMİ KURU, Gökhan MARALCAN, Banu TAYLAN

Monitorize anestezi bakımında propofol ve deksmedetomidinin hemodinamik ve bispektral indeks değerleri açısından karşılaştırılması

Amaç: Çalışmamızda el cerrahisi ameliyatlarında, propofol ve deksmedetomidinin, monitorize anestezi bakımı sırasındaki sedasyon skorları ile hemodinamik ve bispektral indeks (BİS) değerlerini karşılaştırmayı amaçladık. Yöntem: Elektif el cerrahisi planlanan 40 hasta rast gele iki eşit gruba ayrıldı. Sedasyon indüksiyonu Grup D'de 1 fig kg1 deksmedetomidin İV (10 dakikada), Grup P'de ise 1 mg kg$kg^{-1}$ propofol İV (10 dakikada) yapılarak tamamlandı. İndüksiyonu takiben Grup D'ye 0.6-0.7 $mu$ $kg^{-1}$ $sa^{-1}$ dozda deksmedetomidin, Grup P'ye ise 3 mg $kg^{-1}$ $sa^{-1}$ dozda propofol infüzyonu başlandı. Sedasyonun başlangıcından sonra ortalama kan basıncı, kalp atım hızı, dakika solunum sayısı, periferik oksijen satürasyonu (SpO2), sedasyon ve ağrı skorları ile Bispektral indeks (BİS) değerleri kaydedildi. Bulgular: Deksmedetomidin grubunda kan basıncı ve kalp atım hızı daha düşük bulundu (p

Anahtar Kelimeler:

Deksmedetodimin, Anestezi, Propofol

A comparison of the BIS values of propofol and dexmedetomidine in monitored anesthesia care

Objective: In our study we aimed to compare the sedative and hemodynamic effects of propofol and dexmedetomidine by bispectral index during hand surgery. Method: Patients (n=40) undergoing elective hand surgery were randomized into two groups. In group D, sedation was induced with 1 fig $kg^{-1}$ of IV dexmedetomidine (in 10 minutes) followed by an infusion rate of 0.6-0.7 $mu$ $kg^{-1}$ $hour^{-1}$. In group P, induction was done with 1 mg $kg^{-1}$ of IV propofol (in 10 minutes), followed by an infusion rate of 3 mg $kg^{-1}$ $hour^{-1}$. İntra- and postoperative sedation scores, mean blood pressure, heart rate, respiratory rate, peripheral oxygen saturation, pain scores and Bispectral index (BIS) were recorded. Results: The mean blood pressure and heart rate were significantly lower in the dexmedetomidine group (p<0.05). The intraoperative sedation scores and BIS values were significantly lower in the propofol group (p<0.05). Postoperatively they were found to be significantly lower in the dexmedetomidine group (p<0.05). Conclusion: In monitored anesthesia care, dexmedetomidine provides similar sedative effects compared to propofol. However, onset and recovery of sedation were both longer; and blood pressure and heart rates were lower in the dexmedetomidine group. The sedation scores were parallel to the BIS values.

Keywords:

Dexmedetomidine, Anesthesia, Propofol,

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