Deneysel şok modelleri

Yoğun bakım şartlarının iyileşmesi, yeni antibiyotiklerin kullanıma girmesi, yeni tedavi yaklaşımlarının bulunmasına rağmen şokta ölüm oranı hala kabul edilemez derecede yüksektir. Hastaların standardizasyon zorluğu, yaş-cinsiyet farkları, değişik infeksiyon kaynakları gibi çok çeşitli sebepler nedeniyle şokta klinik çalışma yapmak zordur. Bugün deney hayvanlarında yapılan çalışmalar ile, deneysel şok modellerinde, şok fizyopatolojisi hakkında oldukça yoğun bilgi birikimine sahibiz. Bu yazıda, şokta en çok kullanılan deneysel hayvan modelleri yazarın kendi birikimleri ve deneyimleri doğrultusunda metodoloji ve kullanım amaçları ön planda tutularak tartışılacak ve karşılaştırılacaktır.

Anahtar Kelimeler:

Şok, Modeller, hayvan, Endotoksinler, Şok, septik

Experimental shock models

Despite experimental studies, clinical interventions and improved intensive care techniques shock is still a serious circulatory failure with an unacceptably high mortality rate indicating an apparent inefficiency in the current therapeutic modalities. Although some of the differences between animal models and humans preclude direct extrapolation from animals to patients, such studies provide a necessary framework for understanding potential therapeutic agents and how they work. In this mini-review experimental animal models of shock were discussed and compared according to their methodology and usage.

Keywords:

Shock, Models, Animal, Endotoxins, Shock, Septic,

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