Hüseyin BİLGİN, Abdulkadir EREN, Semra KARA

Yardımcı üreme teknolojisi ile doğan bebeklerde konjenital anomaliler ve prognoz

Dünyada günümüze kadar be ş milyondan fazla çocuk yard ı mcı üreme teknolojisi ile do ğ mu ştur. Bu çocuklar ı takip etmek ve spontan gebelik çocuklar ı na göre hastal ı k riskinde artı ş olup olmad ı ğ ı n ı de ğ erlendirmek önemlidir. Son yı llarda, yard ı mc ı üreme teknolojisini ara ş tı ran birçok çal ı ş ma yapı lm ı şt ı r. Bu derleme, yard ı mc ı üreme teknolojisi ile do ğ an çocuklar ı n uzun dönem sonuçlar ı , do ğ umsal defektler ve neonatal sonuçları kapsayan sa ğ l ı k durumu ile ilgili bilgileri özetleyecektir. Yard ı mc ı üreme teknolojisi çocukları n ı n ço ğ u normaldir. Bununla beraber yard ı mcı üreme teknolojisi çocuklar ı n ı n sa ğ l ı k problemi riskinin daha yüksek oldu ğ u yönünde giderek artan kan ı tlar mevcuttur. Bu risk büyük ölçüde dü şük do ğ um a ğ ı rl ı ğ ı , ço ğ ul gebelik ve erken do ğ um sı kl ı ğ ı n ı n yüksek olması na ba ğ l ı d ı r. Bu nedenle, yard ı mc ı üreme teknolojisi sı ras ı nda tek embriyonun transfer edilmesi önerilmektedir.

Over a five million children have been born with assisted conception worldwide. It is important to follow up these children and assess whether they have elevated health risks compared with naturally conceived children. In recent years there have been a lot of studies investigating assisted reproductive technology. This review will summarize the consequences of health in children born with assisted reproductive technology, encompassing neonatal outcomes, birth defects and long term outcomes. Most of the children conceived after assisted reproductive technology are normal. However, there is growing evidence that these children are at higher risk of health problem. These risks are mostly due to the high frequency of the prematurity, multiple pregnancies and low birthweight. Therefore, it is recommended that single embryo should be transferred during assisted reproductive technology.

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