Rabia BALCI, Derya AKDENİZ, Ayşe ÇARLIOĞLU, Feridun KARAKURT, Aysel DERBENT, Yeter BAYRAM

Association of bone mineral density and vitamin D levels in postmenopausal women in Ankara

Amaç: D vitamini, kemik mineralizasyonu için gerekli olup, eksikliğinde osteoporoz, rikets, osteomalazi ve kemik kırıkları oluşabilmektedir. Postmenopozal kadınlarda, fizyolojik olarak hem östrojen hormonu düzeyinin azalması, hem de yaşa bağlı kemik mineral dansitesinde azalma olmaktadır. Postmenopozal kadınlarda kemik sağlığını etkileyebilecek faktörlerin birden fazla olması nedeniyle, D vitamini düzeyleri ve kemik sağlığı arasındaki ilişkinin belirlenebilmesi zordur. Bu nedenle araştırmamızda Ankara şehir merkezinde yaşayan, ev hanımı, menopoz sonrası kadınlarda D vitamini düzeyini ve D vitamininin kemik mineral dansitesi ile arasındaki ilişkiyi belirlemek istedik. Materyal ve Metot: 2012 yaz döneminde Ankarada yaşayan, yaş ortalaması 59,7±9,2 olan, güneş ışığına yeterince maruz kalabilecek şekilde giyinen 223 post- menopozal kadın çalışmaya dahil edildi. Vitamin D, kalsiyum, parathormon, fosfor, kemik tara-ması ve genel laboratuar testleri değerlendirildi. Bulgular D vitamini ortalaması 27,4±21,3 ng/ml olarak saptandı. Osteopenik ve osteoporotik olan gruba göre kıyaslandığında normal kemik dansitometrisi olanlarda D vitamini düzeyleri daha yüksekti (p0,05). Sonuçlar: Sağlıklı kemik mineralizasyonu için, postme- nopozal kadınlar mutlaka D vitamini açısından kontrol edilmeli ve eksikliği durumunda gerekli takviye verilmelidir.

Ankarada yaşayan postmenopozal ev hanımlarına kemik mineral dansitesi ve D vitamini arasındaki ilişkinin açıklanması

Background: It is known that bone mineral density changes with sexual hormone levels and age in postmenopausal women. Introduction: The association between vitamin D levels and bone mineralization in postmenopausal women is not completely understood. Our study aimed to determine the levels of vitamin D in postmenopausal women and their association with bone mineral density. Material and Methods: In summer 2012, 223 postmenopausal housewives (mean age 59.7±9.2) living in Ankara and dressing in a manner such that they could be exposed to sufficient sunlight were included in the study. Vitamin D levels, bone density, serum calcium, phosphorus, magnesium, parathyroid hormone (iPTH), alkaline phosphatase, fasting glucose, lipid profile and thyroid function tests were performed and analysed. Systolic and diastolic blood pressure measurements, exercise, daily sunshine exposure, body mass index and duration of menopause were recorded and associations of these parameters to vitamin D were assessed. Results: The mean level of vitamin D of the cases was found to be 27.4±21.3 ng/ml. The vitamin D level was found to be higher in the group with normal bone densitometry compared to the osteopenic and osteopo- rotic groups (p<0.05). No difference was found between femur neck density and vertebral density in respect to vitamin D levels (p>0.05). Conclusions: To ensure bone mineralization, vitamin D levels of postmenopausal women must be analysed routinely and vitamin D must be supplemented.

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