In vitro examination of toothpastes with Cinnamomum cassia methanolic extract

Objective: In recent years, it has developed resistance to antibiotics and antibacterial chemicals used in the treatment of a large number of bacterial diseases. For this reason, today, an alternative product has been searched for instead of synthetic chemicals. Phytochemicals in traditional medicine and isolated from plants are seen as a good alternative to synthetic chemicals. The purpose of this study; to investigate the antibacterial activity of toothpastes of different contents and toothpastes with Cinnamomum cassia methanolic extract added against Staphylococcus aureus bacteria. Methods: In the study, the experimental set up of six different toothpastes, a positive control group of a flüoride free toothpaste and a distilled water negative control group. The content of C. cassia methanolic extract was determined by GC/MS. Anti-S. aureus activities of toothpastes alone and with C. cassia methanol extract were determined according to the agar disc diffusion method and n = 3 repeats. Inhibition zone diameters were determined using digital calipers and all results were evaluated statistically. Results: According to the GC/MS, cinnamaldehyde, one of the main substances of C. cassia methanolic extract was found to be higher than other components. The most effective toothpaste was found different after adding C. cassia methanol extract and the most effective toothpaste after adding C. cassia methanol extract (p

Cinnamomum cassia metanolik ekstraktı ilave edilen diş macunlarının in vitro incelenmesi

Amaç: Son yıllarda, çok sayıda bakteriyel hastalığın tedavisinde kullanılan antibiyotik ve antibakteriyel kimyasallara karşı direnç gelişmiştir. Bu nedenle, günümüzde sentetik kimyasalların yerine alternatif bir ürün arayışına girilmiştir. Geleneksel tıpta yer alan ve bitkilerden izole edilen fitokimyasallar, sentetik kimyasallara karşı iyi bir alternatif olarak görülmektedir. Bu çalışmanın amacı; farklı içerikteki diş macunlarının ve Cinnamomum cassia metanolik ekstraktı ilave edilmiş diş macunlarının Staphylococcus aureus bakterisine karşı antibakteriyel etkinliğini incelemektir. Yöntem: Çalışmada altı farklı diş macununun deney grubunu, florürsüz bir diş macununun pozitif kontrol grubunu ve distile suyun negatif kontrol grubunu oluşturduğu deney düzeneği kurulmuştur. C. cassia metanolik ekstraktının içeriği GC/MS ile belirlenmiştir. Diş macunlarının tek başlarına ve C. cassia metanol extraktı ile anti-S. aureus aktiviteleri agar disk difüzyon yöntemine göre ve n=3 tekrarlı olarak belirlenmiştir. İnhibisyon zon çapları dijital kumpas kullanılarak belirlenmiş ve tüm sonuçlar istatiksel olarak değerlendirilmiştir. Bulgular: GC/MS ile belirlenen C. cassia metanolik ekstraktının ana maddelerinden olan cinnamaldehyde diğer bileşenlere göre daha yüksek oranda bulunmuştur. C. cassia metanol ekstraktı eklenmeden önce en etkili olan diş macunu ile C. cassia metanol ekstraktı eklendikten sonra en etkili diş macunu farklı bulunmuştur (p

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