Ali İhsan PARLAR, Ufuk TÜTÜN, Seyhan BABAROĞLU, Ahmet Tulga ULUS, Mustafa SEREN, Ferit ÇİÇEKCİOĞLU, Salih Fehmi KATIRCIOĞLU, Müge MISIRLIOĞLU

The effect of genetic polymorphisms on the mechanical heart valve dysfunction

Amaç: Bu çalışmada, mekanik kalp kapağı disfonksiyonu olan hastalardaki genetik polimorfizmler araştırıldı. Çalışma planı: Ocak 1994 - Aralık 2004 tarihleri arasında mekanik kalp kapağı disfonksiyonu nedeni ile yenidenameliyat edilen hastaların oluşturduğu 18 hasta (grup 1), normal fonksiyonel olan ve mekanik kalp kapağı replasmanı yapılmış, uluslararası normalleştirilmiş oran (INR) düzeyleri düşük olan 15 hasta (grup 2) ve 50 sağlıklı kişi(grup 3) olmak üzere, toplam 83 hasta çalışmaya dahiledildi. Faktör V Leiden, protrombin, interlökin (IL-6) vetümör nekroz faktör alfa (TNF-a) polimorfizmleri tespit edilerek, mekanik kalp kapağı disfonksiyonu ile olan muhtemel ilişkileri araştırıldı.Bulgular: İnterlökin-6 polimorfizmi sonuçları, grup 1 vegrup 3 karşılaştırıldığında anlamlı olarak farklı bulundu (p

Mekanik kalp kapağı disfonksiyonunda genetik polimorfizmlerin etkisi

Background: This study aims to investigate geneticpolymorphisms in patients with mechanical heart valvedysfunction.Methods: Between January 1994 and December 2004,a total of 83 patients including 18 patients who werereoperated due to mechanical heart valve dysfunction(group 1), 15 patients with normal functions with lowerinternational normalized ratio (INR) levels who underwentmechanical valve replacement (group 2), and 50 healthyindividuals (group 3) were included. Factor V Leiden,prothrombin, interleukin (IL-6), and tumor necrosis factoralpha (TNF-a) polymorphisms were investigated forpossible relationships between these factors and mechanicalheart valve dysfunction.Results: A significant difference in IL-6 polymorphismwas found between group 1 and group 3 (p

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