Non-steroid anti-enflamatuvar ilaçlar otolog kan plöredezinin etkinliğini azaltır

Amaç: Bu çalışmada bir hayvan modelinde otolog kan plöredezi uygulandı ve parasetamol ve diklofenakın otolog kan plöredezi üzerindeki etkileri araştırıldı. Çalışma planı: Kırk iki dişi Wistar albino sıçanı (üç aylık; ort. ağırlık 275±25 g) 14 sıçanlık üç ana gruba ayrıldı. Her ana grup erken değişiklikler için yedinci günde, geç değişiklikler için 21. günde sakrifiye edilecek şekilde yeniden yedi sıçanlık iki alt gruba ayrıldı. Tüm sıçanlara 3 mL/kg dozunda otolog kan plöredezi uygulandı. Ameliyat sonrası beş ardışık gün boyunca intraperitoneal tek doz şeklinde grup C’ye (kontrol grubu) serum fizyolojik, grup P’ye parasetamol ve grup D’ye diklofenak verildi. Sıçanlar belirlenen tarihlerde sakrifiye edildi ve toraks kafesleri bütün olarak çıkarıldı. Bulgular: Numunelerin makroskopik ve mikroskopik değerlendirmesine göre, parasetamol serum fizyolojiğinkine benzer derecede yapışıklıklar oluşturdu, buna karşın diklofenak iki plevra yaprağı arasındaki istenen yapışıklıkların yoğunluğunu anlamlı şekilde azalttı (p=0.05). Sonuç: Otolog kan plöredezini takiben anti-enflamatuvar analjeziklerin kullanımı işlemin başarısız sonuçlanmasına yol açabilir.

Non-steroid anti-inflammatory drugs reduce the efficacy of autologous blood pleurodesis

Background: This study aims to perform autologous bloodpleurodesis in an animal model and investigate the effects ofparacetamol and diclofenac on autologous blood pleurodesis.Methods: We divided 42 female Wistar albino rats (aged threemonths; average weight 275±25 g) into three major groupsof 14. Each major group was further divided into twosubgroups of seven rats to be sacrificed at seven days forearly changes and 21 days for late changes. We performedautologous blood pleurodesis in all rats at a dose of 3 mL/kg.Group C (control group) was administered saline, group Pwas administered paracetamol, and group D was administereddiclofenac for the postoperative five consecutive days as asingle dose intraperitoneally. We sacrificed the rats at thedesignated dates and removed the thoracic cages en bloc.Results: According to macroscopical and microscopicalevaluation of the specimens, paracetamol led to a similardegree of adhesions with saline, whereas diclofenac significantlyreduced the intensity of the desired adhesions between the twopleural sheets (p=0.05).Conclusion: Using anti-inflammatory analgesics followingautologous blood pleurodesis may lead to unsuccessful outcomeof the procedure.

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