Mustafa APARCI, Zekeriya ARSLAN, Ejder KARDEŞOĞLU, Eyüp BÜYÜKKAYA, Ömer YİĞİNER, Turgay ÇELİK, Ömer UZ, Zafer IŞILAK, Bekir Sıtkı CEBECİ, Ersoy IŞIK

Karotis intima mediya kalınlığının gençlerde coğrafi bölgelere göre değişimi

AMAÇ: Karotis intima mediya kalınlığında artış subklinik aterosklerozun erken bir bulgusu olarak kabul edilmektedir. Günümüzde ateroskleroza yönelik daha erken yaşlarda risk yönetimi önem kazanmaktadır. Bu çalışmada genç yaştaki bireylerin karotis intima mediya kalınlıklarını ve gençlerin yaşadıkları coğrafik bölge ile ilişkili olası değişiklikleri inceledik. YÖNTEM: Toplam olarak 164 genç sağlıklı birey (yaş 21.14± 2.06) çalışmaya dahil edildi. Gençlerin son 10 yıl içerisinde yaşadıkları coğrafik bölgeler kayıt edildi. Gençlerin karotis intima mediya kalınlıkları Logic5Pro Renkli Doppler Cihazı ile transverse prob kullanılarak ölçüldü. Gençlerin IMT değerleri, sistolik ve diyastolik kan basınçları, toplam kolesterol, HDL ve LDL kolesterol düzeyleri ile trigliserid düzeyleri coğrafik bölgere göre karşılaştırıldı. İstatistiki analizler Oneway ANOVA testi ile SPSS 11.0 kullanılarak yapıldı. BULGULAR: Karotis intima mediya kalınlığı Akdeniz (0,416±0,02 mm) ve Güneydoğu Anadolu (0,428±0,04) bölgesinde yaşayan gençlerde anlamlı derecede düşük tespit edilirken Marmara (0,468±0,06 mm) ve İç Anadolu (0,473±0,04) bölgesinde yaşayanlarda anlamlı derecede yüksek olarak tespit edilmiştir. SONUÇ: Çalışmamızın önemli bir sonucu olarak Karotis intima mediya kalınlığındaki bireysel farklılıkların daha genç yaşlarda başladığını ileri sürebiliriz. Bu değişikliklere içinde yaşanılan coğrafik bölgeden kaynaklanan kültürel ve yaşam tarzı farklılıklarının, beslenme alışkanlığı ve diyet içeriğindeki farklılıkların yol açtığı ileri sürülebilir. Karotis intima mediya kalınlığı ölçümü bir tarama testi olarak ateroskleroz açısından riskli bölgelerde yaşayan genç ve erişkin bireylerin subklinik aterosklerotik hastalığının erken tespiti ve müdahalesi için kullanılabilir.

Anahtar Kelimeler:

Karotis intima-media kalınlığı, Türkiye, Akdeniz bölgesi, Varyans analizi, Genç erişkin, Ateroskleroz, Coğrafya

Variability of carotid intima media thickness in youth according to the geographic region

AIM: Carotid intima media thickness (IMT) is proposed to be an earlier predictor of subclinical atherosclerosis. Currently risk management of atherosclerosis at earlier ages gains importance. In this study we evaluated the carotid intima media thickness of young individuals and any possible changes due to the geographic region in which the individuals lived in. METHOD: Totally, 164 young individuals (age 21.14± 2.06) were enrolled to the study. Geographic regions in which they have been living for at least 10 years were documented. Measurements of IMT were performed by Logic5 Pro Color Doppler Device using transverse probe. Measurements of IMT, systolic and diastolic blood pressures, and levels of total cholesterol, HDL, LDL, and triglyceride were compared between the groups designed according to the geographic regions. Statistical analysis was performed by Oneway ANOVA test using SPSS 11.0 for Windows. RESULTS: Carotid IMT was significantly lower in subjects living in Mediterranean (0.416±0.02 mm) and South East Region (0.428±0.04), whereas it increased in subjects living in Marmara Region (0.468±0.06 mm) and Mid-Anatolian Region (0.473±0.04). CONCLUSION: We can propose that individual changes in carotid intima media thickness may develop at younger ages. Differences in dietary habits and its content, also cultural, and environmental differences due to geographic region in which the individuals lived in may contribute those changes. Measurement of IMT could be used as a screening test to detect young individuals with subclinical atherosclerosis in geographic region at risk for atherosclerosis in the future.

Keywords:

Carotid Intima-Media Thickness, Turkey, Mediterranean Region, Analysis of Variance, Young Adult, Atherosclerosis, Geography,

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