2013

Travmatik Beyin Yaralanmasında Magnezyum Sülfat Tedavisinin İyileşme Üzerine Etkisinin Araştırılması

Amaç: Travmatik beyin yaralanmalarına bağlı sakat kalma ve ölüm oranıyüksektir. Ancak bu yaralanmaların zararlı sonuçlarına karşı koruma sağlamakiçin kesin olarak kanıtlanmış farmakolojik tedaviler bulunmamaktadır.Magnezyum travmatik beyin yaralanmasının patofizyolojisinde merkezi birrol oynamaktadır. Bu yaralanmalarda magnezyum sülfat seviyelerinde düşmeolduğu gösterilmiştir. Bu araştırmada travmatik beyin yaralanmalarındaMagnezyum Sülfat tedavisinin etkinliğinin değerlendirilmesi amaçlanmıştır.Yöntem ve Gereçler: Kasım 2008 ve Kasım 2016 arasında Antalya Eğitimve Araştırma Hastanesi yoğun bakım ünitesine kabul edilen travmatik beyinyaralanması olan 18 yaş ve üzeri 60 hasta geriye dönük olarak incelendi.Bulgular: Çalışmaya 60 hasta alındı (ortalama yaş 35.6±17.6, 53 erkek, 7kadın). Glasgow koma skorları Magnezyum Sülfat grubu ve kontrol grubununher ikisinde başvuruda 5, taburculuk sırasında 7, iki ayın sonundaMagnezyum Sülfat grubunda 12, kontrol grubunda 9 tespit edildi (P

Investigation of the Effects of Magnesium Sulfate Therapy on Recovery in Traumatic Brain Injury

Object: The frequency of disability and mortality in traumatic brain injuries is high. However there are no proven pharmacologic therapies to prevent these injuries negative outcome. Magnesium plays central pathophysiological role in trumatic brain injuries. It has been shown that low magnesium levels were associated with these injuries. In this study, we investigate the effects of magnesium sulphate in traumatic brain injuries. Material and Methods: 60 patients, aged over 18, with traumatic brain injury that were admitted to intensive care unit in Antalya Education and Research Hospital between November 2008 and November 2016 were retrospectively analyzed. Results: 60 patients were included in this study (mean age 35.6±17.6 years, 53 male, 7 female). GCS scores were 5 at admission, 7 at the time of discharge in Magnesium Sulphate and control groups, and at the end of two months; it was 12 in Magnesium Sulphate group and 9 in control group (P

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