Transrektal Prostat İğne Biyopsisinin Erektil Fonksiyon Üzerine Etkisi
Amaç: Transrektal ultrasonografi eşliğinde prostat biyopsi işleminin, hastalarıncinsel fonksiyonu üzerine olan etkilerini, işlem öncesinde ve sonrasındafarklı zaman aralıkları ile değerlendirmek. Hastalar ve yöntem: Çalışmayaişlem öncesi Uluslararası Prostat Semptom Skoru (IPSS) ve UluslararasıErektil İşlev Formu (IIEF-5) doldurtulan ve işlem sonrası bu formlar tekrar 1.ve 3. aylarda doldurtulmuş olan ve biyopsi sonucu prostat kanseri ile uyumlugelmeyen 80 hasta alındı. IIEF-5’e göre hastaların erektil fonksiyonları 5 kategoriyeayrıldı; 5-7: ağır erektil disfonksiyon (ED), 8-11: orta ED, 12-16: hafif-orta ED, 17-21: hafif ED, 22-25: ED olmayan. Bulgular: Hastaların %45’i (36/80) üç günden fazla süren rektal kanama şikayeti bildirdiler. Üç gündenuzun süren hematospermi ve/veya hematüri şikayeti hastaların %78,8’inde (63/80) gözlemlendi. Biyopsi öncesi IIEF skor ortalaması 24.3±8.4 idi.Biyopsi sonrası 1. ve 3. aylardaki IIEF skor ortalamaları sırası ile 20.3±9,6 ve22.4±8.9 idi (p
The Impact of Transrectal Prostate Needle Biopsies on Erectile Functions
Object: To evaluate the effects of transrectal ultrasound guided biopsies of the prostate on patients’ sexual function at different time intervals (before and after the procedure). Material and methods: Eighty prostate cancer free patients were included the study, those were completed the International Prostate Symptom Score (IPSS) and International Index of Erectile Function (IIEF-5) before, and 1 and 3 mounths after biopsy. We classified erectile function into five categories according to IIEF-5 scores: severe (5–7), moderate (8–11), mild-moderate (12–16), mild (17-21) and no ED (22–25). Results: 45% (36/80) of the patients notified rectal bleeding complaints continuing for over three days. Hematospermia and /or hematuria complaints that prolonged over three days were observed at 78.8% (63/80) of patients . The mean IIEF score before biopsy was 24.3 ± 8.4. The mean IIEF score at the first and third months after biopsy was 20.3 ± 9.6 and 22.4 ± 8.9, respectively (p
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- Murray KS, Bailey J, Zuk K, Lopez-Corona E, Thrasher
JB. A prospective study of erectile function
after transrectal ultrasonography-guided prostate biopsy.
BJU Int. 2015 Aug;116(2):190-5.
- Chrisofos M, Papatsoris AG, Dellis A, Varkarakis
IM, Skolarikos A, Deliveliotis C. Can prostate biopsies
affect erectile function? Andrologia 2006;38:79–83.
- van den Bergh RC, Korfage IJ, Roobol MJ, Bangma
CH, de Koning HJ, Steyerberg EW, et al. Sexual
function with localized prostate cancer: active surveillance
vs radical therapy. BJU Int 2012;110:1032-9.
- Hilton JF, Blaschko SD, Whitson JM, Cowan JE,
Carroll PR. The impact of serial prostate biopsies on
sexual function in men on active surveillance for prostate
cancer. J Urol 2012;188:1252-8.
- Fujita K, Landis P, McNeil BK, Pavlovich CP. Serial
prostate biopsies are associated with an increased
risk of erectile dysfunction in men with prostate cancer
on active surveillance. J Urol 2009; 182: 2664-9.
- Zisman A, Leibovici D, Kleinmann J, Siegel YI,
Lindner A. The impact of prostate biopsy on patient
well-being: a prospective study of pain, anxiety and
erectile dysfunction. J Urol 2001;165(2):445-54.
- Verrier RL, Dickerson LW. Autonomic nervous system
and coronary blood flow changes related to emotional
activation and sleep. Circulation 1991;83:1181-
1189.
- Feldman HA, Goldstein I, Hatzichristou D, Krane
RJ, McKinlay JB. Impotence and its medical and psychological
correlates: Results of the Massachusets
Male Ageing Study. J Urol 1994;151:54-61.
- Sairam K, Kulinskaya E, Boustead GB, Hanbury
DC, McNicholas TA. Prevalence of undiagnosed
prostate cancer in men with erectile dysfunction. BJU
Int 2002; 89: 261-3.
- Benet AE, Melman A. The epidemiology of erectile
dysfunction. Urol Clin NA 1995;22:699-709.
- Manoharan M, Ayyathurai R, Nieder AM, Soloway
MS. Hemospermia following transrectal ultrasound-
guided prostate biopsy: a prospective study.
Prostate Cancer Prostatic Dis 2007;10:283–7.
- Namekawa T, Fukasawa S, Komaru A, Kobayashi
M, Imamura Y, Ohzeki T et al. Prospective evaluation
of the safety of transrectal ultrasound-guided transperineal
prostate biopsy based on adverse events. Int J
Clin Oncol 2015;20:1185–91.
- Berger AP, Gozzi C, Steiner H, Frauscher F, Varkarakis
J, Rogatsch H et al. Complication rate of transrectal
ultrasound guided prostate biopsy: a comparison
among 3 protocols with 6, 10 and 15 cores. J Urol
2004;171:1478–80.
- Raaijmakers R, Kirkels WJ, Roobol MJ, Wildhagen
MF, Schrder FH. Complication rates and risk factors
of 5802 transrectal ultrasound- guided sextant
biopsies of the prostate within a population-based screening
program. Urology 2002;60:826–30.
- Roberts MJ, Williamson DA, Hadway P, Doi SA,
Gardiner RA, Paterson DL. Baseline prevalence of
antimicrobial resistance and subsequent infection
following prostate biopsy using empirical or altered
prophylaxis: A bias-adjusted meta-analysis. Int J Antimicrob
Agents 2014;43:301-9.
- Liss MA, Taylor SA, Batura D, Steensels D, Chayakulkeeree
M, Soenens C et al. Fluoroquinolone resistant
rectal colonization predicts risk of infectious
complications after transrectal prostate biopsy. J Urol
2014;192:1673-8.
- Bruyere F, Malavaud S, Bertrand P, Decock A, Cariou
G, Doublet JD et al. Prosbiotate: a multicenter,
prospective analysis of infectious complications after
prostate biopsy. J Urol 2015;193:145–50.
- Lundström KJ, Drevin L, Carlsson S, Garmo H,
Loeb S, Stattin P et al. Nationwide population based
study of infections after transrectal ultrasound guided
prostate biopsy. J Urol 2014;192:1116–22.
- Djavan B, Waldert M, Zlotta A, Dobronski P, Seitz C,
Remzi M et al. Safety and morbidity of first and repeat
transrectal ultrasound guided prostate needle biopsies:
results of a prospective European prostate cancer detection
study. J Urol. 2001 Sep;166(3):856-60.
- Loeb S, Carter HB, Berndt SI, Ricker W, Schaeffer
EM. Complications after prostate biopsy: data from
SEER-Medicare. J Urol 2011;186:1830–4.
- Loeb S, Vellekoop A, Ahmed HU,Catto J, Emberton
M, Nam R et al. Systematic review of complications
of prostate biopsy. Eur Urol 2013;64:876–92.