Nutrisyonel Raşitizmde D Vitamini Profilaksisi Programının Sürdürülebilirliğinin Önemi Üzerine Bir Araştırma

Giriş-Amaç: Türkiye’de, çocuklarda D vitamini eksikliğinin ve nutrisyonel raşitizmin (NR) önlenmesi amacıyla 2005 yılında başlatılan proje ile bebeklere ilk 12 ay ücretsiz D vitamini sağlanmış ve sonuçta üç yaş altı raşitizm sıklığında belirgin azalma görülmüştür. Ancak günümüzde halen NR vakaları saptanmakta ve bu vakaların D vitamini profilaksisi kullanmadığı görülmektedir. Materyal-Metod: Bu çalışmada Ocak 2013-Nisan 2018 tarihleri arasında Malatya’da iki Çocuk Endokrin ünitesinde tanı alan üç yaş altı 36 olgu başvuru şikayetleri, fizik muayene, laboratuvar ve görüntüleme bulguları ve aldıkları tedaviler ile sunulmuştur. Bulgular: Olguların %25’i (9/36) son dört ayda tanı almıştır. Olguların tümünde D vitamini düzeyi ≤12,4 ng/mL’dir, ortalama 3,8±2,5 ng/mL. D vitamini profilaksisi sorgulanan 30 hastadan 16’sı hiç profilaksi almamış, 14’ü ise düzensiz almıştır. Sonuç: Kliniğimize başvuran NR vakalarının son yıllarda artması profilaksi programının başlangıçtaki kadar sıkı takip edilmediğine işaret ediyor olabilir. D vitamini profilaksisinin öneminin ve etkinliğinin hekimlerimizce kavranması, programın sıkı bir şekilde takip edilmesi, ailelerin uygun bir şekilde bilgilendirilerek programa dahil edilmesi ile program canlandırılacak ve etkinliği artırılacaktır.

Research on the Importance of the Sustainability of The Vitamin D Prophylaxis Program in Nutritional Rickets

Introduction-Objective: In Turkey, the babies were provided with free vitamin D within their first 12 months through the project launched in 2005 for the purpose of preventing children from vitamin D deficiency and nutritional rickets (NR) and consequently, a significant reduction was observed in the prevalence of rickets among children under three years of age. However, NR cases are still present today and it is seen that these patients do not use vitamin D prophylaxis. Material and Method: In this study, 36 cases under three years of age, who have been diagnosed with NR in two Pediatric Endocrine Units in Malatya between January 2013 and April 2018 were presented along with their complaints during admission, the results of physical examination, laboratory test and imaging and the treatments they have received. Findings: 25% of the cases (9/36) have been diagnosed in the last four months. In all cases, the vitamin D level was ≤12,4 ng / mL, with an average of 3,8 ± 2.5 ng / mL. Of the 30 patients, who were asked about having vitamin D prophylaxis, 16 have not received prophylaxis at all and 14 have received irregularly. Conclusion: The increase in the number of NR cases admitted to our clinic in recent years may indicate that the prophylaxis program is not followed as closely as in the beginning. The prophylaxis program would be revitalized and its effectiveness would be improved when our physicians understand the importance and efficacy of vitamin D prophylaxis, the program is strictly followed and the families are properly informed and included in the program.

___

  • 1. Orbak Z. Rikets. In: Cinaz P, Darendeliler F, Akıncı A, Özkan B, Dündar B.N, Ayhan Abacı A, ed. Çocuk Endokrinolojisi. 1st ed. İstanbul: Nobel Kitabevi; 2014, p:609-14.
  • 2. Craig FM, Nick S, Mairead K et al. Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. J Clin Endocrinol Metab 2016; 101(2):394–415.
  • 3. Hatun Ş, Bereket A, Çalıkoğlu A, Özkan B. Günümüzde D vitamini yetersizliği ve nutrisyonel rikets. Çocuk Sağlığı ve Hastalıkları Dergisi 2003; 46: 224-41.
  • 4. Hatun Ş, Ozkan B, Bereket A. Vitamin D deficiency and prevention: Turkish experience. Acta Pædiatrica 2011; 100: 1195–99.
  • 5. Özkan B, Büyükavcı M, Aksoy H, Tan H, Akdağ R. Erzurum’da 0-3 yaş grubu çocuklarda nutrisyonel rikets sıklığı. Çocuk Sağlığı ve Hastalıkları Dergisi 1999; 42:389–96.
  • 6. Ozkan B, Doneray H, Karacan M, Vancelik S, Yildirim ZK, Ozkan A, et al. Prevalence of vitamin D deficiency rickets in the eastern part of Turkey. Eur J Pediatr 2009; 168: 95–100.
  • 7. Neyzi O, Bundak R, Gökçay G, Günöz H, Furman A, Darendeliler F, Baş F. Reference values for weight, heihgt, head circumference and body mass index in Turkish children. J Clin Res Pediatr Endocrinol 2015; 7(4):280-93.
  • 8.Çocuk Endokrinolojisi ve Diyabet Derneği’nin antropometrik hesaplama uygulaması. http://www.ceddcozum.com
  • 9. Creo AL, Thacher TD, Pettifor JM, Strand MA, Fischer PR. Nutritional rickets around the world: an update. Paediatr Int Child Health 2017;37(2):84-98.
  • 10. Ward LM, Gaboury I, Ladhani M, Zlotkin Vitamin Ddeficiency rickets among children in Canada. SCMAJ. 2007;177(2):161-6.
  • 11. Ross AC, Manson JE, Abrams SA, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 2011;96(1):53–8.
  • 12. Misra M, Pacaud D, Petryk A, Collett-Solberg PF, Kappy M. Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society: Vitamin D deficiency in children and its management: review of current knowledge and recommendations. Pediatrics 2008; 122(2):398-417.
  • 13. Majid Molla A, Badawi MH, al-Yaish S, Sharma P, elSalam RS, Molla AM. Risk factors for nutritional rickets among children in Kuwait. Pediatr Int 2000;42(3):280–4.
  • 14. Dawodu A, Agarwal M, Sankarankutty M, Hardy D, Kochiyil J, Badrinath P. Higher prevalence of vitaminD deficiency in mothers of rachitic than nonrachitic children. J Pediatr 2005;147(1):109–11.
  • 15. Beser E, Cakmakci T. Factors affecting the morbidity of vitamin D deficiency rickets and primary prevention. East Afr Med J 1994; 71:(6):358–62.
  • 16. Gallo S, Comeau K, Vanstone C, et al. Effect of different dosages of oral vitamin D supplementation on vitamin D status in healthy, breastfed infants: a randomized trial. JAMA 2013;309(17):1785–92.
  • 17. Calvo MS, Whiting SJ, Barton CN. Vitamin D fortification in the United States and Canada: current status and data needs. AmJ Clin Nutr 2004;80:1710– 16.
  • 18. Pietrek J, Preece MA, Windo J, et al. Prevention of vitamin-D deficiency in Asians. Lancet. 1976;1(7970):1145–48.
  • 19. Khadgawat R, Marwaha RK, Garg MK, et al. Impact of vitamin D fortified milk supplementation on vitamin D status of healthy school children aged 10– 14 years. Osteoporos Int. 2013;24(8):2335–43.
  • 20. Thacher TD, Fischer PR, Isichei CO, Zoakah AI, Pettifor JM. Prevention of nutritional rickets in Nigerian children with dietary calcium supplementation. Bone 2012;50(5):1074–80.
  • 21. Ekbote VH, Khadilkar AV, Chiplonkar SA, Hanumante NM, Khadilkar VV, Mughal MZ. A pilot randomized controlled trial of oral calcium and vitamin D supplementation using fortified laddoos in underprivileged Indian toddlers. Eur J Clin Nutr 2011;65(4):440–46.
  • 22. Mutlu GY, Kusdal Y, Ozsu E, Cizmecioglu FM, Hatun S. Prevention of Vitamin D deficiency in infancy: daily 400 IU vitamin D is sufficient. Int J Pediatr Endocrinol 2011;2011(1):4
  • 23. Creo AL, Thacher TD, Pettifor JM, Strand MA, Fischer PR. Nutritional rickets around the world: an update. Paediatr Int Child Health 2017 ;37(2):84-98.
  • 24. Açıkgöz A, Günay T, Uçku R. Gebelikte D Vitamini Gereksinimi ve Desteklenmesi. TAF Prev Med Bull 2013;12(5):597-608.
  • 25. Paterson CR, Ayoub D Congenital rickets due to vitamin D deficiency in the mothers. Clin Nutr 2015;34(5):793-8.
  • 26. Soliman A, Salama H, Alomar S, Shatla E, Ellithy K, Bedair E. Clinical, biochemical, and radiological manifestations of vitamin D deficiency in newborns presented with hypocalcemia. Indian J Endocrinol Metab 2013 Jul;17(4):697-70.
STED/Sürekli Tıp Eğitimi Dergisi-Cover
  • ISSN: 1300-0853
  • Yayın Aralığı: Yılda 6 Sayı
  • Başlangıç: 1992
  • Yayıncı: TÜRK TABİPLERİ BİRLİĞİ