KERSETİN YÜKLÜ KİTOSAN NANOPARTİKÜLLERİN İN VİTRO DEĞERLENDİRİLMESİ

Bu çalışmada, antioksidan özellik gösteren doğal polifenolik nanopartikülleri hazırlanmış, in vitro karakterizasyonu ve 24 saat boyunca pH 7.4 fosfat tamponunda salım çalışması yapılmıştır. Salım çalışması boyunca belirlenen zamanlarda alınan örneklerden antioksidan aktivite tayini yapılmıştır. Tüm sonuçlar birlikte değerlendirildiğinde kersetinin ilaç taşıyıcı sisteme başarılı bir şekilde yüklenebildiği ve uzatılmış salım ile gösterdiği antioksidan aktivitenin 24 saat sürdürülebileceği sonucuna varılmıştır.

IN VITRO EVALUATION OF QUERCETIN-LOADED CHITOSAN NANOPARTICLES

In this study, chitosan nanoparticles were prepared with natural, polyphenolic compound, quercetin, characterized in vitro and release study was also performed at 37ºC using pH 7.4 phosphate buffer for 24 h. Antioxidant activity was measured from samples taken at specified time periods throughout release study. When all results were evaluated together, quercetin could load the carrier system successfully and it was concluded that the prolonged antioxidant activity was could be sustained for 24 hours.

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