Diyabette askorbik asit ve çinko metabolizmasının değiştiği ileri sürülmektedir. Bu çalışmanın amacı C vitamini alan insuline bağlı olmayan diyabetes mellituslu (NIDDM) hastalarda çinko düzeyinde değişiklik olup olmadığını belirlemektir. İki aylık standart diyabet diyeti ve C vitamini tedavisi sonrası kan şekerlerine göre hastalar iki gruba ayrıldı: Glisemisi ayarlı grup ve glisemisi ayarsız grup. Her iki grupta açlık kan şekeri ve glikozile hemoglobin (HbA,C) düzeyleri kontrol grubuna oranla yüksekti (Sırasıyla p

It has been suggested that ascorbic acid and zinc metabolism alter in diabetes mellitus. The aim of this study was to determine whether alterations in zinc levels occur in noninsulin dependent diabetic (NIDDM) patients who received ascorbic acid. The patients were divided into two groups: regulated and nonregulated glycemic groups. In both groups, fasting blood glucose and glycated hemoglobin (HbA,C) levels were higher than in the control group (p<0.001, p<0.001). Inversely, plasma ascorbic acid and zinc levels were lower in both groups compared with the control group (p<0.001, p<0.05 respectively). Erythrocyte zinc levels were not different between 0. and 60th day in the irregular glycemic group. Plasma ascorbic acid levels were higher on the 60. day as compared with the 0 day (p<0.01). In the regular glycemic group, plasma ascorbic acid and zinc levels were significantly increased on the 60. day compared with the 0 day (p<0.01, p<0.05 respectively). Erythrocyte zinc levels were not different in the regular glycemic group. In conclusion, ascorbic acid replacement may have a useful effect on plasma zinc levels in NIDDM.