Sema Türker, Cengiz Karaçin, G. İnanç İmamoğlu, Tülay Eren, Ramazan Esen, Ebru Çılbır, Mustafa Altınbaş, Özlem Aydın İsak, Doğan YAZILITAŞ

Kolon kanserinde lokalizasyon ile nötrofil lenfosit oranı arasındaki ilişki

Amaç: Çalışmamızda sağ kolon ile sol kolon yerleşimli tümörler arasındaki farkın iki bölge arasındaki inflamatuvar süreçle ilişkili olup olmadığını basit bir yöntem olan nötrofil lenfosit oranına bakarak karşılaştırmayı amaçladık.Gereç ve Yöntem: Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi Tıbbi Onkoloji bölümüne Temmuz 2011-Haziran 2015 tarihleri arasında başvuran evre 1-3 kolorektal kanser tanısı almış 142 hastanın dosyalarını retrospektif olarak inceledik. Tümör lokalizasyonu ile nötrofil lenfosit oranı (NLO) ve hastalıksız sağ kalım arasında ilişki olup olmadığını araştırdık.Bulgular: Hastalar splenik fleksura baz alınarak sağ ve sol kolon şeklinde ikiye ayrıldı. Sağ kolon olarak tanımladığımız 35 (%24), sol kolon olarak tanımladığımız 107 (%76) hasta vardı. Hastaların 85’i (%60) erkek, 57’si (%40) kadındı. Tanı anındaki NLO karşılaştırıldı. Sağ ve sol kolonun NLO ortalama değerleri sırasıyla 4,43 ve 5,05 olarak hesaplandı. Sağ ve sol kolon arasında NLO açısından istatiksel olarak anlamlı farklılık saptanmadı (p=0.234). Hastalıksız sağ kalım oranları sağ kolon tümörlerinde sol kolona göre istatiksel anlamlılığa ulaşmasa da daha düşük olarak hesaplandı (20. ayda 0,88/0,84; 40. ve 60. ayda sırasıyla 0,80/0,77 ve 0,80/0,77; p =0,064). Sonuçlar: Yaptığımız çalışmada metastatik olmayan kolorektal kanserli hastalarda tanı anında bakılan NLO ile hastalığın lokalizasyonu arasında ilişki bulamadık. Hastalıksız sağ kalım oranlarını sağ kolon tümörlerinde sol kolona göre istatiksel anlamlılığa ulaşmasa da daha düşük olarak hesapladık.

Anahtar Kelimeler:

Sağ-sol kolon, kolorektal kanser, NLO

The relationship between localization and neutrophil lymphocyte ratio in colon carcinoma

Objective: We aimed to compare the neutrophil lymphocyte ratio(NLR), which is a simple method, to determine whether the difference between the right colon and the left colon tumors in our study is related to the inflammatory process between the two regions.Material and Method: We retrospectively reviewed the files of 142 patients who were diagnosed with stage 1-3 colorectal cancer between July 2011 and June 2015 at Medical Oncology Department, Dışkapı Yıldırım Beyazıt Education and Research Hospital. We examined whether tumor localization correlates with neutrophil lymphocyte ratio (NLR) and disease-free survival.Results: The patients were divided into right and left colon based on splenic flexure. There were 35 patients (24%) defined as right colon and 107 (76%) patients defined as left colon. 85 (60%) of the patients were male and 57 (40%) were female. The ratio of neutrophil and lymphocytes at diagnosis was compared. The mean NLR values of the left and right colon were calculated as 4.43 and 5.05, respectively. No statistically significant difference was found between the right and left colon (p = 0.234). The disease-free survival rates were lower in the right colon tumors than in the left colon, but not statistically significant (0,88 / 0,84 40th and 60th at 20th month) 0.80 / 0.77 and0,80/0,77; p = 0.064)Conclusion: In our study, we could not find any relation between the NLR and the localization of the disease in patients with early stage colorectal cancer. Disease-free survival rates were calculated to be lower in right colon tumors, although they did not reach statistical significance with respect to left colon.

Keywords:

Right-left colon, colorectal cancer, NLR,

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