AYŞE BÜYÜKDEMİRCİ, NECLA TÜLEK, MELİHA ÇAĞLA SÖNMEZER, ŞÜKRAN SEVİM, ŞEBNEM ERDİNÇ, GÜNAY ERTEM, PINAR KOŞAR

Herpes simplex virüs–1 ile ilişkili limbik ensefalit: olgu sunumu

ÖzetDünyadaki ölümcül sporadik ensefalitlerin en sık etkeni olan Herpes simplex virüs-1 (HSV-1); çift sarmallı DNA virüsüdür. HSV-1 ensefaliti klinik olarak hızlı başlangıçlı ateş, baş ağrısı, bilinç değişiklikleri, nöbetler ve fokal nörolojik belirtiler ile karakterizedir. Benzer semptom ve bulgularla seyreden paraneoplastik ve otoimmün limbik ensefalit (LE) ise, tümör veya sinaptik proteinlere karşı oluşan antikorlarla gelişmekte ve bu hastalarda bakteriyel ve viral nedenlerin, özellikle HSV-1’e bağlı gelişen ensefalitin ekarte edilmesi gerekmektedir. Bu makalede HSV-1 virüsü ile ilişkili limbik ensefalit gelişen bir olgu sunuldu.

Anahtar Kelimeler:

Herpes simpleks tip I ensefalit, Limbik ensefalit, Kranial manyetik rezonans görüntüleme

Limbic encephalitis associated with herpes simplex virus-1: case report

AbstractHerpes simplex virus-1 (HSV-1) is a double-stranded DNA virus and is the most common cause of fatal sporadic encephalitis world-wide. HSV-1 encephalitis is characterized by rapid onset of fever, headache, altered mental status, seizures and focal neurological symptoms. Paraneoplastic and autoimmune limbic encephalitis (LE) is a condition which presents with similar signs and symptoms, and which develops as a result of antibodies raised against the tumor or synaptic proteins. In patients with this condition, bacterial and viral causes should be excluded, particularly HSV-1 encephalitis. In this report, we present a rare case of limbic encephalitis associated with HSV-1 virus.

Keywords:

Herpes simplex type 1 encephalitis, Limbic encephalitis,

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