Hande KÖKSAL, Hasan BOSTANCI, Sevil KURBAN, Ekrem ERBAY

Akut apandisitte iskemi modifiye albümin

Amaç: Akut apandisitli (AA) hastalarda iskemi modifiye albumin (İMA) düzeyinin saptanması ve prognostik öneminin değerlendirilmesidir. Yöntem ve Gereçler: AA tanısı alan 61 hasta (K/E: 32/29) ile sağlıklı 30 kişi (K/E: 17/13) çalışmaya dahil edildi. Çalışma grubunda kan örnekleri ameliyat öncesi dönemde alındı. İMA düzeyleri kalorimetrik yöntemle ölçüldü ve sonuçlar absorbans ünitesi (ABSU) cinsinden rapor edildi. Bulgular: Akut apandisitli hastalar ile kontrol grubunun İMA değerleri sırası ile 0,42±0,17 ABSU ve 0,37±0,13 ABSU idi. Hasta grubunda İMA değeri kontrol grubuna göre daha yüksek olmasına karşın aradaki fark istatistiksel olarak anlamlı değildi (p>0,05). Yakınma süresi uzun olan, lökositozu ya da nötrofilisi olan hastalarda serum İMA düzeyi daha yüksek olmasına karşın aradaki farklar istatistiksel olarak anlamlı değildi (p>0,05). Ancak, perfore AA’li hastaların serum İMA düzeyleri diğer alt gruplardan daha yüksek bulundu (p

Ischemia modified albumine In acute appendicitis

Aim: Of this study is to detect the IMA(Ischemia Modified Albumin) levels in cases with acute appendicitis(AA) and determine its prognostic value. Material and Methods: 61 patients with acute appendicitis and 30 healthy individuals(control group) were participated to the study Blood samples were taken in preoperative period in study group.IMA levels are measured with calorimetric method and results are reported as Absorbans Unit(ABSU) levels. Results: IMA levels of patients and control group were as follows; 0,42±0,17 ABSU, 0,37±0,13 ABSU.Although IMA levels were higher in patients with leucocytosis and neutrophilia there was no significant difference. (p>0,05). However, the patients with perforated appendicitis were observed to have higher IMA levels than other groups (p

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1.Hardin MD. Acute appendicitis: Review and update. Am Fam Physician 1999; 60: 2027-34.
2.Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 1990;132: 910-25.
3.Birnbaum BA, Wilson SR. Appendicitis at the millenium. Radiology 2000; 215: 337-48.
4.Chan MY, Pronovost PJ. Clinical utility of biomarkers in myocardial injury. Curr Opin Anaesthesiology 2004; 17: 49-55.
5.Talwalkar SS, Bon-Homme M, Miller JJ, Elin RJ. Ischemia modified albumin, a marker of acute ischemic events: a pilot study. Ann Clin Lab Sci. 2008; 38: 132-7.
6.Falkensammer J, Stojakovic T, Huber K, Hammerer-Lercher A, Gruber I, Scharnagl H, et al. Serum levels of ischemia-modified albumin in healthy volunteers after exercise-induced calf-muscle ischemia. Clin Chem Lab Med. 2007; 45: 535-40.
7.Turedi S, Gunduz A, Mentese A, Karahan SC, Yilmaz SE, Eroglu O, et al. Value of ischemia-modified albumin in the diagnosis of pulmonary embolism. Am J Emerg Med. 2007; 25: 770-3.
8.Abboud H, Labreuche J, Meseguer E, Lavallee PC, Simon O, Olivot JM, et al. Ischemia-modified albumin in acute stroke. Cerebrovasc Dis. 2007; 23: 216-20.
9.Gunduz A, Turedi S, Mentese A, Karahan SC, Hos G, Tatli O, et al. Ishemia-modified albumin in the diagnosis of acute mesenteric ischemia: a preliminary study. Am J Emerg Med 2008; 26: 202-5.
10.Köksal H, Kurban S, Şahin M. Laparoskopik kolesistektomi süresince splanknik sahadaki hemodinamik değişikliklerin değerlendirilmesinde iskemi modifiye albuminin rolü. Ulusal Cerrahi Dergisi 2010; 26: 91-4.
11.Bar-Or D, Lau E, Winkler JV. A novel assay for cobalt-albumin binding and its potential as a marker for myocardial ischemia—a preliminary report. J Emerg Med 2000; 19: 311-315.
12.Tehrani HY, Petros JG, Kumar RR, Chu Q. Markers of severe appendicitis. Am Surg 1999; 65: 453-5.
13.Blomqvist PG, Andersson RE, Granath F, Lambe MP, Ekbom AR. Mortality after appendectomy in sweden, 1987-1996. Ann Surg 2001; 233:455-0.
14.Christenson RH, Duh SH, Sanhai WR, Wu AH, Holtman V, Painter P, et al. Characteristics of an albumin cobalt binding test for assessment of acute coronary syndrome patients: a multicenter study. Clin Chem 2001; 47: 464-70.
15.Bar-Or D, Curtis G, Rao N, Bampos N, Lau E. Characterization of the Co2+ and Ni2+ binding amino-acid residues of the N-terminus of human albumin: an insight into the mechanism of a new assay for myocardial ischemia. Eur J Biochem 2001; 268: 42–7.