Assessment of in vitrogenotoxicity effect of homosalate in cosmetics

Many cosmetics contain UV filters as active ingredients for skin protection. Homosalate (HMS) is one of the most widely used organic UV filter. Despite the widespread use of these products, data about their genotoxic effects are lacking. Genotoxicity assessment is an important part of biosafety evaluation; therefore, we aimed to investigate genotoxic effects of homosalate as organic UV filter. The cytotoxicity effects of homosalate were assessed by trypan blue exclusion. Homosalate was incubated with four different concentrations for 30 min and 120 min. Our results revealed that HMS increased the DNA migration both the time and concentration manner. DNA damage was higher in cells that had been incubated with the greatest concentration of 200 μg mL-1(p

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